电离辐射诱导旁效应的研究现状
Recent study of ionizing radiation-induced bystander effects
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摘要: 旁效应是一种电离辐射引起的间接效应,其危险评估受到广泛的重视.随着一些新的先进技术的出现,旁效应机制研究有了新进展,为解释旁效应的发生及调控机制提供了有力的证据.Abstract: An indirect effect induced by ionizing radiation called bystander effect is being highly concentrated. The new achievement by application of advanced tools provides powerful evidence to explain how bystander effects happen and the regulation mechanism.
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Key words:
- Ionizing radiation /
- Radiation effaet /
- Gene expression regulation /
- Microarray
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[1] Nagasawa H,Little JB.Induction of sister chromatid exchanges by extremely low doses of alpha particles.Cancer Res, 1992,52(22):6394-6396. [2] Sokolov MV, Smilenov LB, Hall E J, et al. Ionizing radiation induces DNA double-strand breaks in bystander primary human fibroblasts. Oncogene, 2005, 24(49):7257-7265. [3] Hu B, Wu L, Han W. The time and spatial effects of bystander response in mammalian cells induced by low dose radiation. Carcinogenesis, 2006, 27(2):245-251. [4] Prise KM, Belyakov OV, Folkard M, et al. Studies of bystander effects in human fibroblasts using a charged particle microbeam. Int J Radiat Biol, 1998, 74(6):793-798. [5] Mitchell SA. Randers-Pehrson G Brenner DJ, et al. The bystander response in C3H 10T1/2 cells:the influence of cell-to-cell contact. Radiat Res, 2004, 161(4):397-401. [6] Belyakov OV, MitchellSA, Parikh D, et al. Biological effects in unirradiated human tissue induced by radiation damage up to 1 mm away. Proc Natl Acad Sci USA, 2005, 102(40):14203-14208. [7] Persaud R, Zhou H, Baker SE, et al. Assessment of low linear energy transfer radiation-induced bystander mutagenesis in a three-dimensional culture model. Cancer Res, 2005, 65(21):9876-9882. [8] Azzam EI, de Toledo SM, Little JB, et al. Expression of CONNEXIN43 is highly sensitive to ionizing radiation and other environmental stresses. Cancer Res, 2003, 63:7128-7135. [9] Hei TK. Cyclooxygenase-2 as a signaling molecule in radiation-induced bystander effect. Mol Carcinog, 2006, 45(6):455-460. [10] Shao C, Furusawa Y, Aoki M, et al. Role of gap junctional intercellular communication in radiation-induced bystander effects in human fibroblasts. Radiat Res, 2003.160(3):318-323. [11] VanSlyke JK, Musil LS. Cytosolic stress reduces degradation of connexin43 internalized from the cell surface and enhances gap junction formation and function. Mol Biol Cell, 2005, 16(11):5247-5257. [12] Azzam El, de Toledo SM, Gooding T, et al. Intercellular communication is involved in the bystander regulation of gene expression in human cells exposed to very low fluencies of alpha particles. Radiat Res, 1998, 150(5):497-504. [13] 孙薏,黄越承,周平坤,等.HIV-1 Tat蛋白对细胞周期相关基因表达及辐射细胞周期阻滞的影响.军事医学科学院院刊,2006,30(2):101.
[14] Ponnaiya B, Jenkins-Baker G, Randers-Pherson G, et al. Quantifying a bystander response following microbeam irradiation using singlesuppll-cell RT-PCR analyses. Exp Hematol, 2007, 35(4):64-68. [15] Nagar S, Smith LE, Morgan WF, et al. Characterization of a novel epigenetic effect of ionizing radiation:the death inducing effect. Cancer Res, 2003, 63(2):324-328. [16] Mothersill C, Seymour RJ, Seymour CB, et al. Increased radiosensitiivty in cells of two human cell lines treated with bystander medium from irradiated repair-deficient cells. Radiat Res, 2006, 165(1):26-34. [17] King TJ, Lampe PD. Mice deficient for the gap junction protein Connexin32 exhibit increased radiation-induced tumorigenesis associated with elevated mitogen-activated protein kinase (p44/Erk1, p42/Erk2) activation. Carcinogenesis, 2004, 25(5):669-680. [18] 龙贤辉,徐勤枝,周平坤,等.5cGyγ射线照射正常人淋巴母细胞基因表达转录谱的变化.辐射防护,2006,26(2):78-84.
[19] Chaudhrya M. Bystander effect:Biological endpoints and microarray analysis. Mutat Res, 2006,597(1-2):98-112.
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