电离辐射诱导的细胞G<sub>2</sub>期阻滞

刘光伟; 龚守良

电离辐射诱导的细胞G₂期阻滞

刘光伟 , 龚守良

文章导航 > 国际放射医学核医学杂志 > 2002, 26 > 4: (180-182)

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电离辐射诱导的细胞G₂期阻滞

130021 吉林长春, 吉林大学卫生部放射生物学重点实验室

作者简介: 刘光伟(1973-),男,吉林白城人,博士研究生,主要从事电离辐射生物效应的研究;龚守良(1945-),男,吉林长春人,教授,博士生导师,主要从事电离辐射生物效应的研究。;

中图分类号: Q253;Q345.2

G₂ phase arrest of cell cycle induced by ionizing radiation

MH Radiobiology Research Unit, Jilin University, Jilin Changchun 130021, China
CLC number: Q253;Q345.2

摘要: 哺乳动物受X射线照射后,可以使细胞周期延迟或阻滞,包括G1期阻滞、S期延迟和G₂期阻滞。G1期阻滞仅在野生型p53基因存在时出现,在清除DNA损伤的细胞中具有重要作用;而G₂期阻滞更有利于损伤后DNA的修复和细胞存活,并且与p53基因存在状态无关。因此,对电离辐射诱导细胞G₂期阻滞机制的探讨成为近年来国内外放射生物学领域的研究热点。
- G₂期阻滞 /
- 电离辐射 /
- 细胞周期调控点
Abstract: The exposure of mammalian cells to X rays results in the prolongation of the cell cycle,including the delay or the arrest in G₁,S and G₂ phase.The major function of G₁ arrest may be to eliminate the cells containing DNA damage and only occurs in the cells with wild type p53 function whereas G₂ arrest following ionizing radiation has been shown to be important in protecting the cells from death and occurs in all cells regardless of p53 status.So the study on G₂ phase arrest of the cell cycle induced by ionizing radiation has currently become a focus at radiobiological fields.
- G₂ phase arrest /
- ionizing radiation /
- cell cycle checkpoint
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电离辐射诱导的细胞G₂期阻滞

作者简介:刘光伟(1973-),男,吉林白城人,博士研究生,主要从事电离辐射生物效应的研究;龚守良(1945-),男,吉林长春人,教授,博士生导师,主要从事电离辐射生物效应的研究。

130021 吉林长春, 吉林大学卫生部放射生物学重点实验室

收稿日期: 2002-05-28

关键词:

摘要: 哺乳动物受X射线照射后,可以使细胞周期延迟或阻滞,包括G1期阻滞、S期延迟和G₂期阻滞。G1期阻滞仅在野生型p53基因存在时出现,在清除DNA损伤的细胞中具有重要作用;而G₂期阻滞更有利于损伤后DNA的修复和细胞存活,并且与p53基因存在状态无关。因此,对电离辐射诱导细胞G₂期阻滞机制的探讨成为近年来国内外放射生物学领域的研究热点。