摘要:
目的 通过PET-CT明确18F-氟脱氧葡萄糖在主动脉壁粥样硬化斑块中摄取程度,探讨其临床价值。方法 60例受检者,包括正常对照者6例,大动脉粥样硬化病例54例。测定主动脉壁粥样硬化部位标准化摄取值(SUV)和CT值,并依据CT值将54例主动脉壁局部18F-FDG高摄取的动脉粥样硬化病例分成3组,软斑块组CT值小于60HU,中等斑块组CT值介于60~100HU之间,钙化斑块组CT值大于100HU。第4组为正常对照组。结果 软斑块组42个测量部位的平均SUV为1.553±0.486;中等斑块组30个测量部位的平均SUV为1.393±0.296;钙化斑块组36个测量部位的平均SUV为1.354±0.189;正常对照组33个测量部位的平均SUV为1.102±0.141。多组之间比较差异具有统计学意义(F=678.909,P=0.000);正常组与各斑块组比较差异具有统计学意义。结论 18F-FDG在主动脉粥样硬化斑块中具有不同程度的摄取,其中软斑块对18F-FDG的摄取最高,提示18F-FDG PET-CT是诊断不稳定性主动脉粥样硬化斑块的有价值方法。
Abstract:
Objective To explore the clinical value of PET-CT for the diagnosis of unstable plaques in atherosclerotic lesions. Methods 60 cases underwent whole-body 18F-FDG PET-CT were retrospectively evaluated, including 6 cases with normal control group and 54 cases with atherosclerotic plaques. 54 cases with SUV and CT value in atherosclerotic lesions of large arterial wall were detected retrospectively. 54 high 18F-FDG uptake cases in atherosclerotic plaques were divided into three groups according the CT value:soft plaques group, intermediate plaques group, calcified plaques group. Group 4 was normal. Results In soft plaques group there were 42 sites whose average SUV was 1.553±0.486, in intermediate plaques group there were 30 sites whose average SUV was 1.393±0.296, in calcified plaques group there were 36 sites whose average SUV was 1.354±0.189, in normal control there were 33 sites whose average SUV was 1.102±0.141. The SUV showed significant difference among the four groups (F=678.909, P=0.000). There were significant difference between normal 18F-FDG uptake group and high 18F-FDG uptake groups. Conclusions 18F-FDG had different degree high uptake in large atherosclerotic plaques, the soft plaques had the highest 18F-FDG uptake among them. The results suggested that 18F-FDG PET-CT had significant potential valuable in the diagnosis of unstable soft plaques in atherosclerotic lesions.
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