AT的信号传导

李雨; 潘真; 蔡建明

AT的信号传导

李雨 , 潘真 , 蔡建明

文章导航 > 国际放射医学核医学杂志 > 2001, 25 > 2: (82-86)

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AT的信号传导

200433 上海, 第二军医大学放射医学教研室

作者简介: 李雨(1956-),男,河南开封人,上海第二军医大学放射医学教研室副教授,博士,主要从事DNA辐射损伤和修复的研究。;潘真(1948-),男,江苏溧阳人,上海第二军医大学放射医学教研室教授,博士后,主要从事放射生物医学的研究。;蔡建明(1958-),男,上海南汇人,上海第二军医大学放射医学教研室教授,博士,主要从事放射生物医学的研究。;

中图分类号: R811.5

Signal transduction of ataxia-telangiectasia

Department of Radiation Medicine, Second Military Medical University, Shanghai 200433, China
CLC number: R811.5

摘要: 基因缺陷所致共济失调-毛细血管扩张症(AT)表现为免疫缺陷、进行性共济失调、性腺发育异常、辐射敏感和易患癌症等。本文综述了AT的信号传导,包括AT基因突变和临床症状、电离辐射诱导的信号传导通路中的一些转录因子、细胞周期检控点异常、持续的氧应激和细胞凋亡等。
- 共济失调-毛细血管扩张症 /
- 电离辐射 /
- 信号传导
Abstract: The genetic disorder ataxia-telangiectasia (AT) is characterized by immunodeficiency, progressive cerebellar ataxia, gonadal abnormalities, radiosensitivity, and cancer predisposition. In this paper, the signal transduction of AT are reviewed, including ATM (AT mutated) gene and clinicalsymptoms, some transoription factors in the signaling pathway induced by ionizing radiation, cell cycle checkpoint defects, durative oxidative stress and cell apoptosis.
- ataxia telangiectasia /
- ionizing radiation /
- signal transduction
本作品遵循Signature-Non-Commercial Use 4.0 International (CC BY-NC 4.0)协议

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