Abstract: The authors reported a case of ⁹⁹Tc^m-methylenediphosphonate(MDP) whole-body bone imaging in a child with McCune-Albright syndrome (MAS). The imaging showed multiple abnormal hyperactive and elevated bone metabolism, and were comprehensively evaluated by X-ray, CT and MRI imaging. Pathological examination confirmed the diagnosis of multiple fibrous dysplasia of bone (FDB). MAS is rare in clinical, the authors analyzed the characteristics of MAS from the clinical characteristics and imaging manifestations respectively, and combined with the literature review of ⁹⁹Tc^m-MDP whole body bone imaging features of FDB in different parts, which to provide more references for its diagnosis.