摘要:
目的 探讨放射性粒子与放疗对机体细胞因子的影响。方法 健康雄性大白兔60只,随机分为放射性粒子组、放疗组、对照组各20只,移植VX2瘤株后12 d,对各实验组动物分别进行放射性粒子植入、X射线外照射放疗,对照组不治疗,同时监测血清白细胞介素2(IL-2)、IL-6、IL-8、肿瘤坏死因子(TNF)、胰岛素样生长因子(IGF)水平的变化。结果 实验动物生存期较对照组延长15 d左右。血清IL-2、IL-8逐渐降低,降低幅度对照组 > 放射治疗组 > 放射性粒子组;IL-6、IGF逐渐增高,增高幅度对照组 > 放射治疗组 > 放射性粒子组;TNF逐渐增高,放射治疗组和放射性粒子组变化明显,而对照组变化最小。结论 荷瘤动物的免疫功能呈低下状态,放射性粒子和放疗对细胞因子影响不大,而放射性粒子影响更小;放射性粒子、放疗对VX2瘤治疗效果好。
Abstract:
Objective To discuss the influence of radioactive seeds implantation and radiotherapy on VX2 tumor cytokine. Methods 60 male New Zealand White rabbits were randomly divided into 3 groups, 20 for radioactive seeds implantation group, 20 for radiotherapy group, and 20 for control group. After 12d the implantation with the VX soft tumor, radioactive seeds implantation and radiotherapy were performed separalely, the control group underwent no therapy. IL-2, IL-6, IL-8, TNF and IGF were measured. Results The survival periods of experimental group were 15d longer than the control group. The concentration of IL-2, IL-8 in serum decreased gradually, the decreasing extent control > radiotherapy > radioactive seeds implantation;the concentration of IL-6, IGF raised gradually, rising extent control > radiotherapy > radioactive seeds implantation. Conclusions The immune system of rabbits with VX2 tumor were suppressed, there is little influence of radioactive seeds implantation and radiotherapy on cytokine. Radioactive seeds implantation and radiotherapy are effective methods to treat VX2 tumor.
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