白细胞介素24的研究进展

刘永哲; 金顺子

白细胞介素24的研究进展

刘永哲 , 金顺子

文章导航 > 国际放射医学核医学杂志 > 2007, 31 > 3: (179-182)

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Citation:

白细胞介素24的研究进展

刘永哲,
金顺子^,

130021 长春, 吉林大学公共卫生学院, 卫生部放射生物学重点实验室

通讯作者: 金顺子, shunzij@yahoo.com.cn

中图分类号: Q691

Progress of interleukin-24 study

LIU Yong-zhe,
JIN Shun-zi^,

Key Laboratory of Radiob iology, Ministry of Health, School of Public Health, Jilin University, Changchun 130021, China

Corresponding author: JIN Shun-zi, shunzij@yahoo.com.cn

CLC number: Q691

摘要: 白细胞介素24是白细胞介素10家族的成员,其除细胞因子本质外,还能够诱导不同的肿瘤细胞凋亡,而对正常细胞没有影响.它能促进旁观者抗肿瘤效应,在动物模型中能抑制肿瘤生长和血管形成,具有辐射增敏作用和调节免疫反应作用.
- 白细胞介素类 /
- 细胞凋亡 /
- 辐射耐受性
Abstract: Interleukin-24 (11-24) is a member of interleukin-10 family. Besides its character as a cytokine, IL-24 could induce apoptosis of different kinds of tumor cells without any harmful effects to normal cells. IL-24 could both promote bystander anti-tumor effect,inhibit tumor growth and angiogenesis in animal models. It also has effects of radiosensitization and immunoregulation.
- Interleukins /
- Apoptosis /
- Radiation tolerance
本作品遵循Signature-Non-Commercial Use 4.0 International (CC BY-NC 4.0)协议

[1]	Jiang H,Lin JJ,Su ZZ,et al.Subtraction hybridization identifies a novel melanoma differentiation associated gene,mda-7,modulated during human melanoma differentiation,growth and progression.Oncogene,1995,11(12):2477-2486.
[2]	Caudell EG,Mumm JB,Poindexter N,et al.The protein product of the tumor suppressor gene,melanoma differentiation-associated gene 7,exhibits immunostimulatory activity and is designated IL-24.J Immunol,2002,168(12):6041-6046.
[3]	Huang EY,Madireddi MT,Gopalkrishnan RV,et al.Genomic structure,chromosomal localization and expression profile of a novelmelanoma differentiation associated (mda-7) gene with cancer specific growth suppressing and apoptosis inducing properties.Oncogene,2001,20 (48):7051-7063.
[4]	Fisher PB,Gopalkrishnan RV,Chada S,et al.Mda-7/IL-24,a novel cancer selective apoptosis inducing cytokine gene:from the laboratory into the clinic.Cancer Biol Ther,2003,2(4):23-37.
[5]	Lebedeva IV,Su ZZ,Sarkar D,et al.Melanoma differentiation associated gene-7,mda-7/Interleukin-24,induces apoptosis in prostate cancer cells by promoting mitochondrial dysfunction and inducing reactive oxygen species.Cancer Res,2003,63(23):81388144.
[6]	Pataer A,Vorburger SA,Barber GN,et al.Adenoviral transfer of the melanoma difTerentiation-associated gene-7 induces apoptasis of lung cancer cells via up-regulation the double-stranded RNA-dependent protein kinase (PKR).Cancer Res,2002,62(8):2239-2243.
[7]	Sarkar D,Su ZZ,Lebedeva IV,et al.Mda-7/IL-24 mediates selective apoptosis in human melanoma cells by inducing the coordinated overexpression of the GADD family of genes by means of p38MAPK.Proc Natl Acad Sci USA,2002,99 (15):10054-10059.
[8]	Sauane M,Lebedeva IV,Su ZZ,et al.Melanoma differentiation associated gene-7/interleukin-24 promotes tumor cell-specific apoptosis through both secretory and nonsecretory pathways.Cancer Res,2004,64(9):2988-2993.
[9]	Su Z,Lebedeva IV,Gopalkrishnan RV,et al.A combinatorialapp roach for selectively inducing programmed cell death in human pancreatic cancer cells.Proc Natl Acad Sci USA,2001,98 (18):10332-10337.
[10]	Ramesh R,Mhashilkar AM,Tanaka F,et al.Melanoma differentiation-associated gene 7/Interleukin (IL)-24 is a novel ligand that regulates angiogenesis via the IL-22 receptor.Cancer Res,2003,63(16):5105-5113.
[11]	Mhashilkar AM,Stewart AL,Sieger K,et al.MDA-7 negatively regulates the beta-catenin and PI3K signaling pathways in breast and lung tumor cells.Mol Ther,2003,8:207-219.
[12]	Ramesh R,Ito I,Gopaian B,et al.Ectopic production of MDA-7/IL-24 inhibits invasion and migration of human lung cancer cells.Mol Ther,2004,9(4):510-518.
[13]	Su Z,Emdad L,Sauane M,et al.Unique aspects of mda-7/IL-24 antitumor bystander activity:establishing a role for secretion of MDA-7/IL-24 protein by normal cells.Oncogene,2005,24(51):7552-7566.
[14]	Mhashilkar AM,Schrock HD,Hindi M,et al.Melanoma differentiation associated gene-7 (mda-7):a novel anti-tumor genefor cancer gene therapy.Mol Med,2001,7(4):271-282.
[15]	Nishikawa T,Ramesh R,Munshi A,et al.Adenovirus-mediated mda-7(IL24) gene therapy suppresses angiogenesis and sensitizes NSCLC xenograft tumors to radiation.Mol Ther,2004,9(6):818-828.
[16]	Yacoub A,Mitchell C,Lebedeva IV,et al.Mda-7 (IL-24) Inhibits growth and enhances radiosensitivity of glioma cells in vitro via JNK signaling.Cancer Biol Ther,2003,2(4):347-353.
[17]	Dent P,Yacoub A,Grant S,et al.MDA-7/IL-24 regulates proliferation,invasion and tumor cell radiosensitivity:a new cancer therapy?.J Cell Biochem,2005,95(4):712-719.
[18]	Nishikawa T,Munshi A,Story MD,et al.Adenoviral-mediated mda-7 expression suppresses DNA repair capacity and radiosensitizes non-small-cell lung cancer cells.Oncogene,23(42):7125-7131.
[19]	Emdad L,Sarkar D,Lebedeva IV,et al.Ionizing radiation enhances adenoviral vector expressing mda-7/IL-24-mediated apoptosis in human ovarian cancer.J Cell Physiol,2006,208(2):298-306.
[20]	Su ZZ,Lebedeva IV,Sarkar D,et al.Ionizing radiation enhances therapeutic activity of mda-7/IL-24:overcoming radiation- and mda-7/IL-24-resistance in prostate cancer cells overexpressing th eantiapoptotic proteins bcl-xL or bcl-2.Oncogene,2006,25 (16):2339-2348.

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