188Re在肿瘤治疗中的应用

孙逊

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188Re在肿瘤治疗中的应用

    作者简介: 孙逊(1977-),女,硕士研究生,主要从事肿瘤核医学研究。;
  • 中图分类号: R817.5

Application of 188Re in tumor treatment

  • CLC number: R817.5

  • 摘要: 概述了放射性核素188Re在肿瘤的骨转移治疗、放射免疫治疗、受体介导靶向治疗、腔内治疗及介入治疗等方面的应用,并简单介绍了188Re治疗肿瘤的机制及优势。
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    [2] Hsieh BT, Hsieh JF, Tsai SC, et al. Comparison of various rhenium-188 labeled diphosphonates for the treatment of bone metastases[J]. Nucl Med Biol, 1999. 26(8): 973-976.
    [3] Palmedo H, Guhlke S, Bender H, et al. Dose escalation study with Rhenium-188 hydroxyethylidene diphosphonate in prostate cancer patients with osseous metastases[J]. Eur J Nucl Med, 2000, 27(2): 123-130.
    [4] Liepe K, Franke WG, Kropp J, et al. Comparison of Rhenium 188, Rhenium 186 HEDP and Strontium 89 in palliation of painful bone metastases[J]. Nuklearmedizin, 2000, 39(6): 146-151.
    [5] Blower PJ, Kettle AG, O'Doherty MJ, et al. 99mTc(V)DMSA quantitatively predicts 188Re (V)DMSA distribution in patients with prostate cancer metastatic to bone[J]. Eur J Nucl Med, 2000, 27(9): 1405-1409.
    [6] Limouris GS, Pirmettis Ⅰ, Frantzis AP, et al. Re-188(Sn) labeled -HEDP and -(V)DMSA in the treatment of painful osseous and disseminated soft tissue metastases[J]. Eur J Nuel Med, 1999, 26(suppl): 1208.
    [7] Murray A, Simms MS, Scholfield DP, et al. Production and characterization of 188Re-C595 antibody for radioimmunotherapy of transitional cell bladder cancer[J]. J Nucl Med, 2001, 42(5): 726-732.
    [8] Lou C, Chen ZN, Bian HJ, et al. Pharmacokinetics of radioimmunotherapeutic agent of direct labeling mAb 188Re-HAb18[J]. World J Gastroenterol, 2002, 8(1): 69-73.
    [9] Gestin JF, Loussouarn A, Bardies M, et al. Two-step targeting of xenografted colon carcinoma using a bispecific antibody and 188Re-labeled bivalent hapten: biodistribution and dosimetry studies[J]. J Nucl Med, 2001, 42(1): 146-153.
    [10] Ferro-Flores G, Pimentel-Gonzalez G, Gonzalez-Zavala MAW, et al. Preparation, biodistribution, and dosimetry of 188Re-labeled MoAb iorceal and its F (ab')2 fragments by avidin-biotin strategy[J]. Nucl Med Biol, 1999, 26(1): 57-62.
    [11] Bender H, Zamom PO, Rhodes BA, et al. Clinical aspects of local and regional tumor therapy with 188Re-RC-160[J].Antieaneer Res, 1997, 17(3B): 1705-1712.
    [12] Zinn KR, Buchsbaum D J, Chaudhuri TR, et al. Noninvasive monitoring of gene transfer using a reporter receptor imaged with a high-affinity peptide radiolabeled with 99Tcm or 188Re[J]. J Nucl Med, 2000, 41(5): 887-895.
    [13] Smith CJ, Sieckman GL, Owen NK, et al. Radiochemical investigations of[188Re(H2O)(CO)3-diaminopropionic acid-SSSbombesin(7-14)NH2]: syntheses, radiolabeling and in vitro/in vivo GRP receptor targeting studies[J]. Anticancer Res,2003, 23(1A): 63-70.
    [14] Junfeng Y, Ruping Z, Xinlan D, et al. Intmtumoral injection with [(188)Re]rhenium sulfide suspension for treatment of transplanted human liver carcinoma in nude mice[J]. Nucl Med Biol, 2000, 27(4): 347-352.
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    [7] 金稚奎谭天秩 . 骨转移瘤的放射性核素治疗. 国际放射医学核医学杂志, 1995, 19(4): 145-148.
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  • 收稿日期:  2003-06-07

188Re在肿瘤治疗中的应用

    作者简介:孙逊(1977-),女,硕士研究生,主要从事肿瘤核医学研究。
  • 430022 武汉, 华中科技大学同济医学院附属协和医院核医学科

摘要: 概述了放射性核素188Re在肿瘤的骨转移治疗、放射免疫治疗、受体介导靶向治疗、腔内治疗及介入治疗等方面的应用,并简单介绍了188Re治疗肿瘤的机制及优势。

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