<sup>13</sup>C-尿素呼气试验技术改进及对幽门螺杆菌感染的诊断

王冰

¹³C-尿素呼气试验技术改进及对幽门螺杆菌感染的诊断

王冰

文章导航 > 国际放射医学核医学杂志 > 2000, 24 > 5: (209-212)

引用本文:

Citation:

¹³C-尿素呼气试验技术改进及对幽门螺杆菌感染的诊断

王冰

200065 上海, 上海同济大学医学院附属同济医院核医学科

作者简介: 王冰(1972-),女,河北泊头市人,上海同济大学医学院附属同济医院核医学科住院医师,硕士,主要研究稳定核素的临床应用。;

中图分类号: R377;R443.6

Modified ¹³C-urea breath test and the detection of Helicobacter pylori

WANG Bing

Department of Nuclear Medicine, Tongji hospital Affiliated to Medical School of Tongji University, Shanghai 200065, China
CLC number: R377;R443.6

摘要: ¹³C-尿素呼气试验(¹³C-UBT)是诊断幽门螺杆菌(Hp)感染的重要方法之一。它具有无毒、无创伤、准确、快速等优点,但检测价格昂贵的问题一直阻碍着该方法的推广。近年来,研究人员在保证诊断灵敏度及特异性的前提下,对¹³C-UBT进行了多方面的改进,如新型价廉的检测仪器,低剂量¹³C-尿素胶囊的应用,试验餐的改良及检测时间的缩短等,降低了检测成本,大大推动了¹³C-UBT的更广泛应用。
- ¹³C-尿素呼气试验 /
- 幽门螺杆菌
Abstract: The ¹³C-urea breath test (¹³C-UBT) is one of the most important non-invasive methods for detecting Helicobacte pylori infection. This examination is innocuous, simple, highly accutate. While the major drawback of ¹³C-UBT is the higher cost compared with other methods which hold back its widely using. This review focuses on the most recent advances in the machines used to measure the ¹³C isotope and on the most important improvements about the UBT, such as the use of lower dose ¹³C-urea tablet or capsule, the modification of test meal, a shortened collection time of exhalation sample and so on.
- ¹³C-urea breath test /
- Helicobacter pylori
本作品遵循Signature-Non-Commercial Use 4.0 International (CC BY-NC 4.0)协议

[1]	胡伏莲. 幽门螺杆菌感染基础与临床[M].北京:中国科学技术出版社, 1997. 271-274.
[2]	Graham DY, Klein PD, Evans DJ Jr, et al. Campylobac-ter pylori detected non-invasively by ¹³C-urea breath test[J]. Lancet, 1987, 323:1174-1177.
[3]	Savarino V, Mela GS, Zentilin P, et al. Comparison of isotope ratio mass spectrometry and nondispersive iso-tope-selective infrared spectroscopy for ¹³C-urea breath test[J]. Am J Gastroenterol, 1999, 94(5):1203-1208.
[4]	Laine L, Estrada R, Trujillo M, et al. Effect of pro-ton pump inhibitor therapy on diagnostic testing for Helicobacter pylori[J]. Ann Intern Med, 1998, 129:547-550.
[5]	Savarino V, Bisso G, Pivari M, et al. Effect of gastric acid suppression on ¹³C-urea breath test:comparison of ranitidine with omeprazole[J]. Aliment Pharmacol Ther, 2000, 14(3):291-297.
[6]	Connor SJ, Ngu MC, Katelaris PH. The impact of short-term ranitidine use on the precision of the ¹³C-urea breath test in subjects infected with Helicobacter pylori[J]. Eur J Gastroenterol Hepatol, 1999, 11 (10):1135-1138.
[7]	Klein PD, Malaty HM, Martin RF, et al. Noninva-sive detection of Helicobacter pylori infectionin clinical practice:the ¹³C-urea breath test[J]. Am J Gastroen-terol, 1996, 91:690-693.
[8]	Kato M, Asaka M, Ohara S, et al. Clinical studies of ¹³C-urea breath test in Japan[J]. J Gastroenterol, 1998, 33 (Suppl 10):36-39.
[9]	Savarino V, Mela GS, Zentilin P, et al. Comparison of isotope ratio mass spectrometry and nondispersive isotope-selective infrared spectroscopy for ¹³C-urea breath test[J]. Am J Gastroenterol, 1999, 94(5):1203-1208.
[10]	Dominguez-Munoz JE, Leodolter A, Sauerbruch T, et al. A citric acid solution is an optimal test drink in the ¹³C-urea breath test for the diagnosis of Helicobacter pylori infection[J]. Gut, 1997, 40(4):459-462.
[11]	Cadranel S, Corvaglia L, Bontems P, et al. Detection of Helicobacter pylori infectionin children with a stan-dardized and simplified ¹³C-urea breath test[J]. J Pedi-atr Gastroenterol Natr, 1998, 27(3):275-280.
[12]	Canena J, Santos AM, Reis J, et al. ¹³C urea breath test (UBT) for Helicobacter pylori diagnosis. Is it possible to use a new low dose procedure[J]. Am J Gastroenterol, 1997, 92:1610-1614.
[13]	Hamlet A, Stage L, Lonroth H, et al. A novel tablet-based ¹³C urea breath test for Helicobacter pylori with enhanced performance during acid suppression therapy[J]. Scand J Gastroenterol, 1999, 34(4):367-374.
[14]	Leodolter A, Dominguez-Munoz JE, Von Arnim U, et al. Citric acid or orange juice for the ¹³C-urea breath test:the impact of pH and gastric emptying[J]. Ali-ment Pharmacol Ther, 1999, 13(8):1057-1062.
[15]	Moayyedi P, Braunholtz D, Heminbrough E, et al. Do patients need to fast for a ¹³C-urea breath test?[J]. Eur J Gastroenterol Hepatol, 1997, 9:274-277.
[16]	Tanahashi T, Kodama T, Yamaoka Y, et al. Analysis of the ¹³C-urea breath test for detection of Helicobac-ter pylori infection based on the kinetics of delta-¹³CO₂ using laser spectroscopy[J]. J Gastroenterol Hepatol, 1998, 13(7):732-737.
[17]	Kato M, Asaka M, Kudo T, et al. Ten minute ¹³C-urea breath test for the diagnosis of Helicobacter py-lori infection[J]. J Gastroenterol, 1998, 33(Suppl 10):40-43.
[18]	Logan RPH, Dill S, Bauer FE, et al. The European ¹³C-urea breath test for the detection of Helicobacter pylori[J]. Eur J Gastroenterol Hepatol, 1991, 3:915-921.
[19]	Sheu BS, Lee SC, Yang HB, et al. Selection of lower cutoff point of[¹³C] urea breath test is helpful to moni-tor H. pylori eradication after proton pump inhibitor-based triple therapy[J]. Dig Dis Sci, 2000, 45(7):1330-1336.
[20]	Ellenrieder V, Glasbrenner B, Stoffels C, et al. Qual-itative and semi-quantitative value of a modified ¹³C-urea breath test for identification of Helicobacter py-lori infection[J]. Eur J Gastroenterol Hepatol, 1997, 9 (11):1088-1089.

[1]	匡安仁 , 谭天秩 , 韩佩珍 . ¹⁴C-尿素呼吸试验诊断幽门螺杆菌感染. 国际放射医学核医学杂志, 1996, 20(6): 246-249.
[2]	徐克强 , 张万岱 , 周殿元 , 韩佩珍 . 呼吸试验对幽门螺杆菌感染的诊断价值. 国际放射医学核医学杂志, 1996, 20(6): 241-246.
[3]	严惟力 , 蒋义斌 . ¹³C呼气试验的方法学及在胃肠病临床的应用. 国际放射医学核医学杂志, 2002, 26(5): 196-199.
[4]	徐仁铎 , 夏振民 . ¹⁴C-尿素呼气检查程序指导. 国际放射医学核医学杂志, 1999, 23(2): 68-70.
[5]	濮伟刚 , 谭纪伏 , 朱建华 , 杨永青 . 血浆中四种肿瘤标志物和¹³C-尿素呼气试验对胃癌诊断的对比研究. 国际放射医学核医学杂志, 2010, 34(2): 94-96, 104. doi: 10.3760/cma.j.issn.1673-4114.2010.02.008
[6]	荆卫娟 , 杨永青 . 慢性萎缩性胃炎向胃癌转化时血清胃泌素和幽门螺杆菌的变化及其作用. 国际放射医学核医学杂志, 2009, 33(6): 341-343. doi: 10.3760/cma.j.issn.1673-4114.2009.06.006
[7]	Klcin PD . ¹³C呼气试验——诊断和流行病学研究的工具. 国际放射医学核医学杂志, 1989, 13(2): 78-80.
[8]	严惟力 , 孙大裕 , 林祥通 , 蒋义斌 , 孙旭 , 戎兰 , 梁棋 . L-[1-¹³C]苯丙氨酸呼气试验定量检测肝脏功能动物实验研究. 国际放射医学核医学杂志, 2006, 30(1): 9-13.
[9]	毛奇琦 , 孙旭 , 严惟力 . ¹³C呼气试验:一种有益的消化系统疾病检测方法. 国际放射医学核医学杂志, 2009, 33(3): 129-132. doi: 10.3760/cma.j.issn.1673-4114.2009.03.001
[10]	王火强 , 吴继琮 , 吴靖川 , 谭天秩 . ¹³CO₂呼气试验在脂肪代谢研究中的应用. 国际放射医学核医学杂志, 1992, 16(4): 178-181.

点击查看大图

计量

文章访问数: 1310
HTML全文浏览量: 273
PDF下载量: 4

¹³C-尿素呼气试验技术改进及对幽门螺杆菌感染的诊断

王冰

作者简介:王冰(1972-),女,河北泊头市人,上海同济大学医学院附属同济医院核医学科住院医师,硕士,主要研究稳定核素的临床应用。

200065 上海, 上海同济大学医学院附属同济医院核医学科

收稿日期: 2001-01-09

关键词:

¹³C-尿素呼气试验 /
幽门螺杆菌

摘要: ¹³C-尿素呼气试验(¹³C-UBT)是诊断幽门螺杆菌(Hp)感染的重要方法之一。它具有无毒、无创伤、准确、快速等优点,但检测价格昂贵的问题一直阻碍着该方法的推广。近年来,研究人员在保证诊断灵敏度及特异性的前提下,对¹³C-UBT进行了多方面的改进,如新型价廉的检测仪器,低剂量¹³C-尿素胶囊的应用,试验餐的改良及检测时间的缩短等,降低了检测成本,大大推动了¹³C-UBT的更广泛应用。