立体定向放射治疗胰腺癌
Stereotactic radiotherapy for pancreatic cancer
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摘要: 目的 对立体定向放射治疗胰腺癌的临床意义进行评价。方法 对16例胰腺癌患者行立体定向放射治疗,病变体积26.5~116.5cm3,肿瘤边缘单次剂量为3~5Gy,治疗10~20次,每日1次,每周治疗5次,治疗后临床和影像手段随访。结果 治疗有效率(完全缓解+部分缓解)为81.2%,合并疼痛患者均有不同程度缓解,6/7患者黄疸消除,生存质量明显改善,中位生存期11个月,死亡原因多为远处转移;治疗副作用根据RTOG标准评价,68.7%患者有轻度早期反应,1例重度晚期反应。结论 立体定向放射治疗胰腺癌是有效的局部控制手段,可明显的缓解症状,改善患者生存质量,并且治疗的并发症可以被临床接受,但肿瘤的远处转移是影响患者生存的主要问题。Abstract: Objective To evaluate the therapeutic effects of stereotactic radiotherapy (SRT) on pancreatic cancer. Methods Sixteen patients were treated with SRT, tumor volume 26.5~116.5cm3, single tumor dosage ranged from 3Gy to 5Gy in 10 to 20 fractions, five fractions per week. Patients were followed clinically and image. Results The overall response rate (CR+PR) was 81.2%; the life quality has been improved in evidence. The median survival time was 11 months; the most reason of death was metastasis:The evaluation for acute and late complications related to the treatment was base on RTOG standard, 68.7% patients developed acute complications, and one patient had developed grievously later responses. Conclusion Stereotactic radiotherapy can be used effectively to local control in patients with pancreas cancer, improves life quality, and complications related to the treatment can be accepted by clinically, but tumor metastasis is significantly related with the survival time of patients, combined chemotherapy may be improve survival rate of the patients.
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Key words:
- Pancreatic neoplasms /
- Stereotactic radiotherapy /
- Prognosis
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