TSH受体抗体及临床意义

何建华 曾钦文

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TSH受体抗体及临床意义

    作者简介: 何建华(1963-),男,重庆市人,重庆市第二人民医院核医学科主任,主要从事临床核医学诊断和治疗工作。;曾钦文(1996-),男,重庆市人,重庆市第二人民医院核医学科主治医师,主要从事临床核素治疗工作。;
  • 中图分类号: R446.62

Thyrotropin receptor antibodies and its clinical application

  • CLC number: R446.62

  • 摘要: 促甲状腺素受体抗体(TRAb)不是均一性抗体,它至少包括四种抗体,这些抗体的测定在自身免疫性甲状腺疾病GD及其甲状腺以外组织表现以及其他甲状腺疾患的诊断、评估疗效、确定停药时机、预测复发及监测高危人群等方面均具有重要临床意义。
  • [1] Watanabe Y,Tahara K,Hirai A,et al.Subtypes of ani-TSH receptor antibodies classified by various as-says using CHO cells expressing wild-type or chimeric human TSH receptor[J].Thyroid,1997,7(1):13-19.
    [2] Akamizu T,M oriyama K,Miura M,et al.Characteri-zation of combinant monoclonal antithyrotropin recep-tor antibodies (TSHRAbs) derived from lymphocytes of patients with Graves' disease:epitope and binding study of two stimulatory TSHRAbs[J].Endocrinolo-gy,1999,140(4):1594-1601.
    [3] AkamizuT,Kohn LD,Hiratani H,et al.Hashimoto's thyroiditis with heterogeneous antithy-rotropin receptor antibodies:unique epitopes may con-tribute to the regulation of thyroid function by the an-tibodies[J].J Clin Endocrinol Metab,2000,85(6):2116-2121.
    [4] Meller J,Jauho A,Hufner M,et al.Disseminated thyroid autonomy or Graves' disease:revaluation by a second generation TSH receptor antibody assay[J].Thyroid,2000,10(12):1073-1079.
    [5] Costagliola S,Morgenthaler NG,Hoermann R,et al.Second generation assay for thyrotropin receptor anti-bodies has superior diagnostic sensitivity for Graves' disease[J].J Clin Endocrinol Metab,1999,84(1):90-97.
    [6] Khoo DH,Eng PH,Ho SC,et al.Graves' ophthal-mopathy in the absence of elevated free thyroxine andtriiodothyronine levels:prevalence,natural history,and thyrotropin receptor antibody levels[J].Thyroid,2000,20(22):1093-1100.
    [7] Morgenthaler NG,Pampel I,Aust G.Application of a bioassay with CHO cells for the routine detection of stimulating and blocking autoantibodies to the TSH-receptor[J].Horm Metab Res,1998,30(3):162-168.
    [8] Giordabo C,Stassi G,De Mria R,et al.Potential in-volve,ent of Fas and its ligand in the pathogenesis of Hashimoto's thyroiditis[J].Scienee,1997,275:960-963.
    [9] Noh JY,Hamada N,Inoue Y,et al.Thyroid-stimu-lating antibody is related to Graves' ophthalmopathy,but thyrotropin-binding inhibitor immunoglobulin is related to hyperthyroidism in patients with Graves' disease[J].Thyroid,2000,10(9):809-813.
    [10] Khoo DH,Ho SC,Seah LL,et al.The combination of absent thyroid peroxidase antibodies and high thyroid-stimulating immunoglobulin levels in Graves' disease identifies a group at markedly increased risk of oph-thalmopathy[J].Thyroid,1999,9(12):1175-1180.
    [11] Gerding MN,van der Meer JW,Broenink M,et al.Association of thyrotrophin receptor antibodies with the clinical features of Graves' ophthalmopathy[J].Clin Endocrinol,2000,52(3):267-271.
    [12] Iitaka M,Momotani N,Hisaoka T,et al.TSH recep-tor antibody-associated thyroid dysfunction following subacute thyroiditis[J].Clin Endocrinol,1998,48(4):445-453.
    [13] Takasu N,Yamashiro K,Komiya I,et al.Remission of Graves' hyperthyroidism predicted by smooth de-creases of thyroid-stimulating antibody and thy-rotropin-binding inhibitor immunoglobulin during an-tithyroid drug treatment[J].Thyroid,2000,10:891-896.
    [14] Momotani N,Yamashita R,Makino F,et al.Thyroid function in wholly breast-feeding infants whose moth-ers take high doses of propylthiouracil[J].Clin En-docrinol,2000.53(2).177-181.
    [15] Jones BM,Kwok CC,Kung AW,et al.Effect of ra-dioactive iodine therapy on cytokine production in Graves' disease:transient increases in interleukin-4(IL-4),IL-6,IL-10,and tumor necrosis factor-alpha,with longn term increses in interferon-gamma produc-tion[J].J Clin Endocrinol Metab,1999,84(11):4106-4110.
    [16] Nygaard B,Knudsen JH,Hegedus L,et al.Thy-rotropin receptor antibodies and Graves' disease,a side-effect of 131 I treatment in patients with nontoxicgoiter[J].J Clin Endocrinol Metab,1997,82 (9):2926-2930.
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  • 收稿日期:  2001-02-10

TSH受体抗体及临床意义

    作者简介:何建华(1963-),男,重庆市人,重庆市第二人民医院核医学科主任,主要从事临床核医学诊断和治疗工作。;曾钦文(1996-),男,重庆市人,重庆市第二人民医院核医学科主治医师,主要从事临床核素治疗工作。
  • 400026 重庆, 重庆市第二人民医院核医学科

摘要: 促甲状腺素受体抗体(TRAb)不是均一性抗体,它至少包括四种抗体,这些抗体的测定在自身免疫性甲状腺疾病GD及其甲状腺以外组织表现以及其他甲状腺疾患的诊断、评估疗效、确定停药时机、预测复发及监测高危人群等方面均具有重要临床意义。

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