Ku蛋白在肿瘤发生中的作用及其靶向抑制策略

任振义; 金一尊

任振义 , 金一尊

文章导航 > 国际放射医学核医学杂志 > 2008, 32 > 5: (305-307)

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Ku蛋白在肿瘤发生中的作用及其靶向抑制策略

任振义¹,
金一尊²

1. 310006 杭州, 杭州市第一人民医院呼吸内科;
2. 200032 上海, 复旦大学放射医学研究所
基金项目:
卫生部科研基金(wkj2005-2-051)

杭州市科技局资助项目(20080333810)

The role of Ku protein in the development of carcinogenesis and potential strategy for silencing it

REN Zhen-yi¹,
JIN Yi-zun²

1. Department of Respiratory Medicine, First Hospital of Hangzhou, Hangzhou 310006, China;
2. Research Institute of Radiation Medicine, Fudan University, Shanghai 200032, China

摘要: Ku蛋白参与辐射诱导的DNA损伤修复,严重影响着肿瘤细胞的辐射敏感性。细胞内Ku蛋白异常表达与肿瘤发生和发展存在密切关系。目前,研究者试图抑制Ku蛋白表达来增强肿瘤细胞的辐射敏感性,为进一步靶向治疗奠定基础。
- DNA双链断裂 /
- DNA修复 /
- 肿瘤 /
- 辐射耐受性
Abstract: The vital role of Ku protein is implement for DNA double strand break repair.Abnormal expression of Ku protein contributes to the development of carcinogenesis.The scientist are trying to enhance radiation-induced tumor control by inhibiting the Ku protein and have shown promising results.

本作品遵循Signature-Non-Commercial Use 4.0 International (CC BY-NC 4.0)协议

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