SDF-1的生物学功能及在干/祖细胞归巢中的作用

孙苏平

孙苏平

文章导航 > 国际放射医学核医学杂志 > 2001, 25 > 6: (272-273)

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SDF-1的生物学功能及在干/祖细胞归巢中的作用

孙苏平

200433 上海, 第二军医大学放射医学教研室

作者简介: 孙苏平(1956-),男,江苏徐州人,博士研究生,主要从事辐射损伤修复、恶性肿瘤放射治疗等方面的研究。;

基金项目:
国家自然科学基金项目(39770329

39600077)
中图分类号: R331.2

Biological function of SDF-1 and its role in homing of haemopoietic stem/progenitor cells

SUN Su-ping

Deparment of Radiation Medicine, Second Military Medical University, Shanghai 200433, China
CLC number: R331.2

摘要: 造血干/祖细胞归巢的分子机制尚不清楚。近年来的研究发现,基质细胞来源的细胞因子或称为趋化蛋白SDF-1及其配体CXCR4参与了趋化造血干/祖细胞向骨髓的迁徙、与骨髓微血管内皮的粘附、穿内皮迁徙、与骨髓基质细胞粘附的归巢全过程,在干/祖细胞归巢过程中可能有关键性的作用。
- 造血干/祖细胞 /
- SDF-1/CXCR4 /
- 归巢
Abstract: The molecular mechanism of homing of haemopoietic stem/progenitor cells is beyond understanding.Recent years,however,it have been found that a chemokine or chemoat-tractant stromal cell-derived factor 1 (SDF 1) and its ligand CXCR4 receptor may involve in the process of transendothelial migration and adhere to bone marrow stromal cells.It may play key role in homing of haemopoietic stem/progenitor cells.
- haemopoietic stem/progenitor cells /
- SDF-1/CXCR4 /
- homing
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[1]	Tashiro K, Tada H, Heilker R, et al.Singnal sequence trap:A cloning strategy for secreted proteins and type 1 membrane proteins[J].Science, 1993, 261(5121):660-662.
[2]	Nagasawa T, Kikutani H and Kishimoto T.Molecuar cloning and structure of a pre-B cell growthstimulating factor[J].Proc Natl Acad Sci USA, 1994, 91(6):2305-2309.
[3]	Shirozu M, Nakano T, Inazawa J, et al.Structure and chromo-somallocalization of the human stromal cellderived factor 1(SDF1)gene[J].Gennomics, 1995, 28(3):495-500.
[4]	Bleul CC, Fuhlbrigge RC, Casasnovas JM, et al.A highly effi-cacious lymphocyte chemoattractant, stromal cell-derived factor-1(SDF-1)[J].J Exp Med, 1996, 184(3):1101-1109.
[5]	Rempel SA, Dudas S, Ge SG, et al.Identification and locali-zation of the cytokine SDF-1 and its receptor, CXC chemokine recepor 4, to regions of necrosis and angiogensis in human glioblastoma[J].Clin Cancer Res, 2000, 6(1):102-111.
[6]	Nagasawa T, Hirota S, Tachibana K, et al.Defects of B-cell lymphoposis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1[J].Natur, 1996, 382(6592):635-638.
[7]	Ma Q, Jones D, Borghesani PR, et al.Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4 and deficient mice[J].Proc Natl Acad Sci USA, 1998, 95(16):9448-9453.
[8]	Campbell JJ, Hedrick J, Zlotnik A, et al.Chemokines and the arrest of lymphocytes rolling under flow condition[J].Science, 1998, 279(5349):381-383.
[9]	Peled A, Grabovsky V, Habler L, et al.The chemokine SDF-1 stimulates integrin-mediated arrest of CD34⁺ cell on vascular endothelium undershear flow[J].J Clin Invest, 1999, 104(9):1199-1211.
[10]	Hamada T, Mohle R, Hesselgesser J, et al.Transendothelial migration of megakaryocytes in response to stromal cell-derived factor 1(SDF-1)[J].J Exp Med, 1998, 188(3):539-548.
[11]	Koshiba T, Hosotani R, Miyamoto Y, et al.Expression of stomal cell-derived factor 1 and CXCR4 ligand receptor system in pancreatic cancer:A possible role for tumor progression[J].Clin Cancer Res, 2000, 6(9):3530-3535.
[12]	Bleul CC, Farzan M, Choe H, et al.The lymphocyte chemoa-ttractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry[J].Nature, 1996, 382(6594):829-835.
[13]	Aiuti A, Tavian M, Cipponi A, et al.Expression of CXCR4, the receptor for stromal cell-derivd factor-1 on fetal and adult human lymphohematopoietic progenitors[J].Eur J Immunol, 1999, 29(6):1823-1831.
[14]	Imai K, Kobayashi M, Wang JX, et al.Selective secretion of chemoattractants for haemopoietic progenitor cells by bone marrow endothelial cell:a possible role in homing of haemopoietic progenitor cells to bone marrow[J].Br J Haemato, 1999, 106(4):905-911.
[15]	Mohle R, Bautz F, Rafii S, et al.The chemokine receptor CXCR4 is expressed on CD34⁺ hematopoietic progenitors and leukemic cells and mediates transendothelial migration induced by stromal cell-derived factor-1[J].Blood, 1998, 91(12):4523-4530.
[16]	Peled A, Petit I, Kollet O, et al.Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4[J].Science, 1999, 283(5403):845-848.
[17]	Voermans C, Kooi ML, Rodenhuis S, et al.In vitro migratory capacty of CD34⁺ cells is related to hematopoietic recovery after autologous stem cell transplantation[J].Blood, 2001, 97(3):799-804.
[18]	Lapidot T.Mechanism of human stem cell migration and repopulation of NOD/SCID and B2mnull NOD/SCID mice.The role of SDF-1/CXCR4 interactions[J].Ann NY Acad Sci, 2001, 938:83-95.

[1]	姜福全 . 造血干细胞“归巢”机制的探讨. 国际放射医学核医学杂志, 2000, 24(5): 234-236.
[2]	张占英 . 放射损伤病人的造血干/祖细胞移植研究进展. 国际放射医学核医学杂志, 2000, 24(5): 223-226.
[3]	于洪臣 , 刘及 , 李光宇 . 照射后造血基质祖细胞的再生. 国际放射医学核医学杂志, 1985, 9(1): 31-31.
[4]	许廷贵 , 刘及 . 造血微环境祖细胞的放射敏感性. 国际放射医学核医学杂志, 1981, 5(1): 57-57.
[5]	卢绍平 , 徐承熊 . 高温对小鼠造血祖细胞的作用. 国际放射医学核医学杂志, 1984, 8(3): 177-178.
[6]	于洪臣 , 王立华 , 刘及 . 造血基质祖细胞的辐射敏感性研究进展. 国际放射医学核医学杂志, 1994, 18(5): 193-197.
[7]	刘民培 , 张卿西 , 刘及 . 人骨髓多能造血祖细胞(CFU-GEMM)的辐射敏感性. 国际放射医学核医学杂志, 1982, 6(3): 184-184.
[8]	陈德政 , 陈家佩 . 骨髓长期培养的造血基质祖细胞的辐射敏感性. 国际放射医学核医学杂志, 1984, 8(3): 175-176.
[9]	于洪臣 , 刘及 , 李光宇 . 长期培养的骨髓的造血基质祖细胞的辐射敏感性. 国际放射医学核医学杂志, 1985, 9(1): 31-32.
[10]	张鸿来 , 刘及 , 高凤鸣 . γ线连续全身照射对狗淋巴造血祖细胞(CFU-GM、CFU-L)及可能存在的造血调节细胞群的效应. 国际放射医学核医学杂志, 1987, 11(1): 29-30,62.