Egr-1基因的辐射生物学效应研究进展

许建华

Egr-1基因的辐射生物学效应研究进展

许建华

文章导航 > 国际放射医学核医学杂志 > 2002, 26 > 2: (76-79)

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Egr-1基因的辐射生物学效应研究进展

许建华

215007 江苏苏州, 苏州大学核医学院放射毒理系

作者简介: 许建华(1975-),男,江苏昆山人,硕士研究生,主要从事电离辐射毒理学相关研究。;

中图分类号: Q503;Q274

Advances in the research of the role of Egr-1 gene in cells' response to ionizing radiation

XU Jian-hua

Nuclear Medicine School, Suzhou University, Jiangsu Suzhou 215007, China
CLC number: Q503;Q274

摘要: Egr-1(early growth response-1)基因是一系列"立即早期基因(immediateearly gene)"之一,参与细胞的多种辐射生物效应。研究表明,Egr-1在多种正常细胞和肿瘤细胞受到电离辐射后的早期就能被激活,它的激活表达与辐照后细胞的生长、周期、凋亡等的改变密切相关。另外,Egr-1基因调控序列具有辐射可诱导特性,这一特点使其具有潜在的临床和基因工程生产应用前景。
- Egr-1 /
- 细胞凋亡 /
- 细胞周期 /
- 辐射敏感性
Abstract: Egr-1(early growth response-1)gene is an important member of the "Immediate Early Growth" gene family,participating in multiple radiation biological effects of the irradiated cells.Studies have shown that after ionizing radia-tion,Egr-1 gene can be activated at an early stage in many types of tumor and normal cells.Its actitivation and the conse-quent expression is believed to have a close relation to the change in cell growth,cell cycle and apoptosis of the irradiat-ed cells. Additionally,the radiation-inducible property of the Egr-1 gene regulating sequence confers potential clinical and genetic engineering uses.
- early growth response-1 /
- apoptosis /
- cell cycle /
- radiation sensitivity
本作品遵循Signature-Non-Commercial Use 4.0 International (CC BY-NC 4.0)协议

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Egr-1基因的辐射生物学效应研究进展

许建华

作者简介:许建华(1975-),男,江苏昆山人,硕士研究生,主要从事电离辐射毒理学相关研究。

215007 江苏苏州, 苏州大学核医学院放射毒理系

收稿日期: 2001-10-15

关键词:

摘要: Egr-1(early growth response-1)基因是一系列"立即早期基因(immediateearly gene)"之一,参与细胞的多种辐射生物效应。研究表明,Egr-1在多种正常细胞和肿瘤细胞受到电离辐射后的早期就能被激活,它的激活表达与辐照后细胞的生长、周期、凋亡等的改变密切相关。另外,Egr-1基因调控序列具有辐射可诱导特性,这一特点使其具有潜在的临床和基因工程生产应用前景。