瘦素的表达与肿瘤的关系

朱文茹; 左书耀

瘦素的表达与肿瘤的关系

朱文茹 , 左书耀

文章导航 > 国际放射医学核医学杂志 > 2005, 29 > 4: (164-166)

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瘦素的表达与肿瘤的关系

266003 青岛, 青岛大学医学院附属医院核医学科
中图分类号: R730.44

Relationship between leptin expression and tumor

Department of Nuclear Medicine, Third Hospital, Hebei Medical University, Shijiazhuang 050051, China
CLC number: R730.44

摘要: 瘦素(leptin)是由肥胖基因编码的一种蛋白质产物,与代谢调节密切相关,在人体能量平衡、脂肪代谢的调节以及在神经内分泌系统、生殖和造血系统的影响中起着重要的作用。瘦素与人类多种肿瘤相关,提示瘦素作为一种新的肿瘤标志物,在肿瘤的早期诊断中起重要作用。
- 瘦素 /
- 肿瘤 /
- 放射免疫分析
Abstract: Leptin, a protein product encoded by the obese gene, has relationship with the regulation of the metabolism. This compound has been implicated for the regulation of energy balance, fat metabolism and has an important part in neural endocrinology and reproductive system and hematogenous system. Leptin has relations with many tumors diseases. It implies that leptin will be acted as a new tumor marker has an important role in early diagnoses of the tumors.
- leptin /
- tumor /
- radioiommunoassay
本作品遵循Signature-Non-Commercial Use 4.0 International (CC BY-NC 4.0)协议

[1]	Stattin P, Soderbery S, Hallmans G, et al. Leptin is associated with increased prostate cancer risk:a nested case-referent study[J]. J Clin Endocrinol Metab, 2001, 86(3):1341-1345.
[2]	Chang S, Hursting SD, Contois JH, et al. Leptin and prostate cancer[J]. Prostate, 2002, 46(1):62-67.
[3]	Onuma M, Bub JD, Rummel TL, et al. Prostate cancer cell-adopocyte interaction:leptin mediates androgen-independent prostate cancer cell proliferation through c-Jun NH₂-terminal kinase[J]. J Biol Chem,2003, 278(43):42660-42667.
[4]	Hardwick JC, Van Den Brink GR, Offerhaus GJ, et al. Leptin is a growth factor for colonic epithelial cells[J]. Gastroenterology, 2001,121(1):79-90.
[5]	Liu Z, Uesaka T, Watanabe H, et al. High fat diet enhances colonic cell proliferation and carcinogenesis in rats by elevating serum leptin [J]. Int J Oncol, 2001, 19(5):1009-1014.
[6]	Hino M, Nakao T, Yamane T, et al. Leptin receptor and leukemia[J].Leuk Lymphoma, 2000, 36(5-6):457-461.
[7]	Bruserud O, Huang TS, Glenjen N, et al. Leptin in human acute myelogenous leukemia:studies of in vivo levels and in vitro effects on native functional leukemia blasts[J]. Haematologica, 2002, 87(6):584-595.
[8]	Laud K, Gourdou I, Pessemesse L, et al. Identification of leptin receptors in human breast cancer:functional activity in the T47-D breast cancer cell line[J]. Mol Cell Endocrinol, 2002, 188(1-2):219-226.
[9]	Tessitore L,Vizio B, Jenkins O, et al. Leptin expression in colorectal and breast cancer patients[J]. Int J Mol Med, 2000, 5(4):421-426.
[10]	董庆玉,高菊兴,张纪云,等.血清胰岛素样生长因子-1、瘦素以及性激素与女性乳腺癌的相关性研究[J].放射免疫学杂志,2003,16(6):360-362.
[11]	朱步东,刘淑俊,刘娟,等.血清瘦素对恶性肿瘤患者营养状况的影响[J].卫生研究,2002,31(2):100-102.

[1]	赵明辉 . 瘦素应用于肥胖症研究. 国际放射医学核医学杂志, 2001, 25(5): 193-198.
[2]	濮伟刚 , 谭纪伏 , 朱建华 , 杨永青 . 血浆中四种肿瘤标志物和¹³C-尿素呼气试验对胃癌诊断的对比研究. 国际放射医学核医学杂志, 2010, 34(2): 94-96, 104. doi: 10.3760/cma.j.issn.1673-4114.2010.02.008
[3]	王金萍 , 吴秋莲 , 徐浩 . 甲状腺功能与血清饥饿素和瘦素水平的相关陛研究. 国际放射医学核医学杂志, 2008, 32(4): 221-223.
[4]	雷呈志 . 瘦素和体重调节反馈模式的研究. 国际放射医学核医学杂志, 2002, 26(2): 60-63.
[5]	谭庆玲 , 张惠 , 陈碧玲 . 多囊卵巢综合征患者肾上腺雄激素水平与胰岛素抵抗的关系. 国际放射医学核医学杂志, 2011, 35(6): 358-361. doi: 10.3760,cma.j.issn.1673-4114.2011.06.009
[6]	谭庆玲 , 张惠 , 陈碧玲 . 多囊卵巢综合征患者肾上腺雄激素水平与胰岛素抵抗的关系. 国际放射医学核医学杂志, 2011, 35(6): 358-361. doi: 10.3760/cma.j.issn.1673-4114.2011.06.009
[7]	吴湖炳 , 彭武和 , 黄祖汉 . 肿瘤放射免疫显像的亲和素-生物素系统. 国际放射医学核医学杂志, 1998, 22(6): 248-251.
[8]	庞华 . 标记免疫分析技术及其进展. 国际放射医学核医学杂志, 2002, 26(5): 213-216.
[9]	李晔 , 王学斌 . 放射性标记的维生素B12及其衍生物在肿瘤诊治中的应用进展. 国际放射医学核医学杂志, 2003, 27(6): 255-259.
[10]	韩佩珍 . 化学发光免疫分析. 国际放射医学核医学杂志, 2000, 24(5): 196-201.