双语认知的功能性脑显像研究

孙达

双语认知的功能性脑显像研究

孙达

310009 杭州, 浙江大学医学院附属第二医院核医学科

Study of functional brain imaging for bilingual language cognition

SUN Da

Department of Nuclear Medicine, Secoud Affiliated Hospital, Medical College of Zhejiang University, Hangzhou 310009, China

摘要: 双语和多语的大脑语言认知功能研究涉及语言神经表现,是一个跨学科的课题,需要神经解剖、神经功能、生物化学、精神和语言的不同水平的鉴别和区分。此外,特异的因素,如年龄、获得的方式和环境因素也影响神经表现。功能性脑显像,如PET、SPECT和功能性MRI可以探查双语受试者的语言神经表现,阐明大脑对双语认知的机制。功能性脑显像的研究显示,虽然两种语言的脑认知机制分享共同的成分,但与受试者母语比较,与第二语言有关的脑活性的类型不尽相同,表明两种不相关语言的词记忆处理既有共同的神经系统,也有不同的皮层区介导。不同的活性类型不仅与所使用的语言不同相关,也归因于获得的年龄或熟练水平,而达到熟练程度比获得的年龄更重要。PET研究显示,手语和口语似乎定位在同样的脑区,具有类似的局部脑血流类型;但手语还取决于空间信息,当健康正常的双语受试者用视觉方法感知手语时,功能解剖与既含有听觉又含有视觉成分的语言处理重叠。
- 语言试验 /
- 正电子发射断层显像术 /
- 体层摄影术,发射型计算机,单光子 /
- 磁共振显像
Abstract: Bilingual and multilingual brain studies of language recognition is an interdisciplinary subject which needs to identify different levels involved in the neural representation of languages, such as neuroanatomical, naurofunctional, biochemical, psychological and linguistic levels. Furthermore, specific factors such as age, manner of acquisition and environmental factors seem to affect the neural representation. Functional brain imaging, such as PET, SPECT and functional MRI can explore the neurolinguistics representation of bilingualism in the brain in subjects, and elucidate the neuronal mechanisms of bilingual language processing. Functional imaging methods show differences in the pattern of cerebral activation associated with a second language compared with the subjects native language. It shows that verbal memory processing in two unrelated languages is mediated by a common neural system with some distinct cortical areas. The different patterns of activation differ according to the language used. It also could be ascribed either to age of acquisition or to proficiency level. And attained proficiency is more important than age of acquisition as a determinant of the cortical representation of the second language. The study used PET and SPECT shows that sign and spoken language seem to be localized in the same brain areas, and elicit similar regional cerebral blood flow patterns. But for sign language perception, the functional anatomy overlaps that of language processing contain both auditory and visual components. And the sign language is dependent on spatial information too.
- Language tests /
- Positron-emission tomography /
- Tomography,emission-computed,single-photon /
- Magnetic resonance imaging
本作品遵循Signature-Non-Commercial Use 4.0 International (CC BY-NC 4.0)协议

[1]	Halsband U,Krause BJ,Sipilä H,et al.PET studies on the memory processing of word pairs in bilingual Finnish-English subjects[J].Behav Brain Res,2002,132(1):47-57.
[2]	Halsband U.Bilingual and multilingual language processing[J].J Physiol Paris,2006,99(4-6):355-369.
[3]	Klein D,Watkins KE,Zatorre RJ,et al.Word and nonword repetition in bilingual subjects:a PET study[J],Hum Brain Mapp,2006,27(2):153-161.
[4]	Klein D,Zatorre RJ,Milner B,et al.Left putaminal activation when speaking a second language:evidence from PET[J].Neuroreport,1994,5(17):2295-2297.
[5]	Filley CM,Ramsberger G,Menn L,et al.Primary progressive aphasia in a bilingual woman[J].Neurocase,2006,12(5):296-299.
[6]	Mariën P,Abutalebi J,Engelborghs S,et al.Pathophysiology of language switching and mixing in an early bilingual child with subcortical aphasia[J].Neurocase,2005,11(6):385-398.
[7]	Söderfeldt B,Ingvar M,Rönnberg J,et al.Signed and spoken language perception studied by positron emission tomography[J].Neurology,1997,49(1):82-87.
[8]	Rönnberg J,Rudner M,Ingvar M.Neural correlates of working memory for sign language[J].Brain Res Cogn Brain Res,2004,20(2):165-182.
[9]	McGuire PK,Robertson D,Thacker A,et al.Neural Correlates of thinking in sign language[J].Neuroreport,1997,8(3):695-698.
[10]	Kang E,Lee DS,Kang H,et al,The neural correlates of cross-modal interaction in speech perception during a semantic decision task on sentences:a PET study[J].Neuroimage,2006,32⑴:423-431.
[11]	Horwitz B,Amunts K,Bhattacharyya R,et al.Activation of Broca's area during the production of spoken and signed language:a combined cytoarchitectonic mapping and PET analysis[J].Neuropsychologia,2003,41(14):1868-1876.
[12]	Tierney MC,Varga M,Hosey L,et al.PET evaluation of bilingual language compensation following early childhood brain damage[J].Neuropsychologia,2001,39(2):114-121.
[13]	李宝荣,彭聃龄,郭桃梅.汉英语义通达过程的事件相关电位研究[J].心理学报,2003,35(3):309-316.
[14]
[15]	伍建林,何立岩,张清,等.汉字与英文字形辨认的脑功能磁共振成像初步研究[J].中国临床医学影像杂志,2004,15(4):181-184.
[16]	Perani D,Paulesu E,Galles NS,et al.The bilingual brain.Proficiency and age of acquisition of the second language[J].Brain,1998,121(Pt 10):1841-1852.
[17]	Li G,Cheung RT,Gao JH,et al.Cognitive processing in Chinese literate and illiterate subjects:an fMRI study[J].Hum Brain Mapp,2006,27(2):144-152.

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双语认知的功能性脑显像研究

310009 杭州, 浙江大学医学院附属第二医院核医学科

收稿日期: 2008-06-23

关键词:

摘要: 双语和多语的大脑语言认知功能研究涉及语言神经表现,是一个跨学科的课题,需要神经解剖、神经功能、生物化学、精神和语言的不同水平的鉴别和区分。此外,特异的因素,如年龄、获得的方式和环境因素也影响神经表现。功能性脑显像,如PET、SPECT和功能性MRI可以探查双语受试者的语言神经表现,阐明大脑对双语认知的机制。功能性脑显像的研究显示,虽然两种语言的脑认知机制分享共同的成分,但与受试者母语比较,与第二语言有关的脑活性的类型不尽相同,表明两种不相关语言的词记忆处理既有共同的神经系统,也有不同的皮层区介导。不同的活性类型不仅与所使用的语言不同相关,也归因于获得的年龄或熟练水平,而达到熟练程度比获得的年龄更重要。PET研究显示,手语和口语似乎定位在同样的脑区,具有类似的局部脑血流类型;但手语还取决于空间信息,当健康正常的双语受试者用视觉方法感知手语时,功能解剖与既含有听觉又含有视觉成分的语言处理重叠。

Study of functional brain imaging for bilingual language cognition

Department of Nuclear Medicine, Secoud Affiliated Hospital, Medical College of Zhejiang University, Hangzhou 310009, China

Received Date: 2008-06-23

Abstract: Bilingual and multilingual brain studies of language recognition is an interdisciplinary subject which needs to identify different levels involved in the neural representation of languages, such as neuroanatomical, naurofunctional, biochemical, psychological and linguistic levels. Furthermore, specific factors such as age, manner of acquisition and environmental factors seem to affect the neural representation. Functional brain imaging, such as PET, SPECT and functional MRI can explore the neurolinguistics representation of bilingualism in the brain in subjects, and elucidate the neuronal mechanisms of bilingual language processing. Functional imaging methods show differences in the pattern of cerebral activation associated with a second language compared with the subjects native language. It shows that verbal memory processing in two unrelated languages is mediated by a common neural system with some distinct cortical areas. The different patterns of activation differ according to the language used. It also could be ascribed either to age of acquisition or to proficiency level. And attained proficiency is more important than age of acquisition as a determinant of the cortical representation of the second language. The study used PET and SPECT shows that sign and spoken language seem to be localized in the same brain areas, and elicit similar regional cerebral blood flow patterns. But for sign language perception, the functional anatomy overlaps that of language processing contain both auditory and visual components. And the sign language is dependent on spatial information too.

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