1H-MRS定量测定脑代谢物的研究

林艳 饶海冰 吴仁华

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1H-MRS定量测定脑代谢物的研究

  • 基金项目:

    国家自然科学基金资助项目(30270379/C010511)

  • 中图分类号: R445.2

Investigation of quantitative measurement of brain metabolite concentration using 1H nuclear magnetic resonance spectroscopy

  • CLC number: R445.2

  • 摘要: 磁共振频谱(magnetic resonance spectroscopy,MRS)是利用核磁共振基本成像原理及其化学位移和自旋耦合现象,在活体上无创伤地测定能量代谢和体内化学物的一种检测技术,为疾病诊断和治疗提供有价值的信息。长期以来,MRS分析的脑代谢物检测结果以代谢物之间的比率来表达,但不可靠,近年来应用内标准和装有标准脑代谢物的外标准来获得脑代谢物的绝对浓度。在临床MRS应用中,代谢物绝对浓度的分析较比率分析有更多优点。本文就MRS的基本原理及1H-MRS定量测定脑代谢物浓度的方法作一综述。
  • [1] Li BS, Wang H, Gonen O. Metabolite ratios to assumed stable creatine level may confound the quantification of proton brain MR spectroscopy[J]. Magn Reson Imaging, 2003, 21(8):923-928.
    [2] Vermathen P, Capizzano AA, Maudsley AA. Administration and 1H MRS detection of histidine in human brain:application to in vivo pH measurement[J]. Magn Reson Med, 2000, 43(5):665-675.
    [3] Tong Z, Yamaki T, Harada K, et al. In vivo quantification of the metabolites in normal brain and brain tumors by proton MR spectroscopy using water as an internal standard[J]. Magn Reson Imaging,2004, 22(7):1017-1024.
    [4] Silverstone PH, Donnell T, Ulrich M, et al. Dextro-amphetamine increases phosphoinositol cycle activity in volunteers:an MRS study[J]. Hum Psychopharmacol, 2002,17(7):321-327.
    [5] Wu RH, Donnell T, Ulrich M, et al. Brain choline concentrations may not be altered in euthymic bipolar disorder patients chronically treated with either lithium or sodium valporate[J]. Ann Gen Hosp Psychiatry, 2004, 3(1):13.
    [6] Shen J, Douglas L, Rothman, et al. In vivo GABA editing using a novel doubly selective multiple quantum filter[J]. Magn Reson Med,2002, 47(3):447-454.
    [7] Donnell T, Rotzinger S, Nakashima TT, et al. Chronic lithium and sodium valproate both decrease the concentration of myo-inositol and increase the concentration of inositol monophosphates in rat brain[J]. Eur Neuropsychopharmacol, 2003, 13(3):199-207.
    [8] Sager TN, Laursen H, Fink-Jensen A, et al. N-acetylaspartate distribution in rat brain striatum during acute brain ischemia[J]. J Cereb Blood Flow Metab, 1999, 19(2):164-172.
    [9] Wu RH, Silverstone P, Rao HB, et al. Quantitative measurement of brain metabolite concentrations using PRESS sequence at 3T[J].Radiology, 2002, 225(p):667.
    [10] Kimura T, Sako K, Gotoh T, et al. In vivo single-voxel proton MR spectroscopy in brain lesion with ring-like enhancement[J]. NMR Biomed, 2001, 14(6):339-349.
    [11] Simister RJ, Mclean MA, Barker GJ, et al. Proton MRS reveals frontal lobe metabolite abnormalities in idiopathic generalized epilepsy[J]. Neurology, 2003, 61(7):897-902.
    [12] Seeger U, Klose U, Mader I, et al. Parameterized evaluation of macromolecules and lipids in proton MR spectroscopy of brain diseases[J]. Magn Reson Med, 2003, 49(1):19-28.
    [13] Mclean MA, Woermann FG, Barker GJ, et al. Quantitative analysis of short echo time 1H-MRSI of cerebral gray and white matter[J].Magn Reson Med, 2000, 44(3):401-411.
    [14] Hajek M, Burian M, Dezortova M. Application of LC-model for quality control and quantitative in vivo 1H-MR spectroscopy by short echo time STEAM sequence[J]. Magn Reson Materials Phy Bio 1 Med,2000, 10(1):6-17.
    [15] Mclean MA, Busza AL, Wald LL, et al. In Vivo GABA+ Measurement at 1.5T using a PRESS-localized double quantum filter[J].Magn Reson Med, 2002, 48(2):233-241.
    [16] Tyson RL, Gallagher C, Sutherland GR. 13C-labeled substrates and the cerebral metabolic compartmentalization of acetate and lactate[J]. Brain Res, 2003, 992(1):43-52.
    [17] Gruetter R, Seaquist ER, Kim SG, et al. Localized in vivo 13C-NMR of glutamate metabolism in the human brain:initial results at 4 tesla[J]. Dev Neurosci, 1998, 20(4-5):380-388.
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  • 收稿日期:  2004-11-30

1H-MRS定量测定脑代谢物的研究

  • 515041 汕头, 汕头大学医学院第二附属医院放射科
基金项目:  国家自然科学基金资助项目(30270379/C010511)

摘要: 磁共振频谱(magnetic resonance spectroscopy,MRS)是利用核磁共振基本成像原理及其化学位移和自旋耦合现象,在活体上无创伤地测定能量代谢和体内化学物的一种检测技术,为疾病诊断和治疗提供有价值的信息。长期以来,MRS分析的脑代谢物检测结果以代谢物之间的比率来表达,但不可靠,近年来应用内标准和装有标准脑代谢物的外标准来获得脑代谢物的绝对浓度。在临床MRS应用中,代谢物绝对浓度的分析较比率分析有更多优点。本文就MRS的基本原理及1H-MRS定量测定脑代谢物浓度的方法作一综述。

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