心肌肌钙蛋白Ⅰ的临床应用及检测方法进展

赵保健

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心肌肌钙蛋白Ⅰ的临床应用及检测方法进展

    作者简介: 赵保健(1978-),男,硕士研究生,主要从事抗体制备研究。;
  • 中图分类号: R446.62

The cinical utilization and development of assay for cardiac troponin I

  • CLC number: R446.62

  • 摘要: cTnI(心肌肌钙蛋白Ⅰ)是心肌肌钙蛋白的一种亚型,正常人血液中含量很低,当心肌细胞损伤时,cTnI在血液中的含量迅速升高。近年来随着cTnI检测方法的不断改进,cTnI已成为最具有临床价值的心肌损伤标志物之一,被广泛应用于心脏疾患的临床诊断和检测。
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    [3] Apple FS,Falahati A,Paulsen PD,et al. Improved detection of minor ischemic myocardiac injury with measurement of serum cardiac troponin I[J]. Clin Chem,1997,43: 2047-2051.
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    [14] Heeschen C, Goldmann BU, Langenbrink L, et al. Evaluation of a rapid whole blood ELISA for quantification of troponin I in patients with acute chest pain[J]. Clin Chem, 1999, 45: 1789-1796.
    [15] Hafner G, Peetz D, Erbes H, et al. Comparison of diagnostic performance of cardiac troponin I on the IMMULITE system with other automated troponin I assays in minor myocardial damage[J]. Scand J Clin Lab Invest, 2001, 61: 227-236.
    [16] Katrukha AG, Bereznikova AV, Esakova TV, et al. Troponin I is released in bloodstream of patients with acute myocar-diac infarction not in free form but as complex[J]. Clin Chem, 1997,43: 1379-1385.
    [17] Bunk DM, Dalluge JJ, Welch MJ. Heterogeneity in human cardiac Troponin I stardards[J]. Anal Biochem, 2000, 284: 191-200.
    [18] Katrukha AG, Bereznikova AV, Filatov VL, et al. Degradation of cardiac troponin I: implication for reliable immun-odetection[J]. Clin Chem, 1998, 44: 2433-2440.
    [19] Larue C, Defacque-Lacquement H, Calzolari C, et al. New monoclonal antibodies as probes for human cardiac troponin I: epitopic analysis with synthetic peptides[J]. Mol Immunol, 1992, 29,271-278.
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  • 收稿日期:  2003-05-22

心肌肌钙蛋白Ⅰ的临床应用及检测方法进展

    作者简介:赵保健(1978-),男,硕士研究生,主要从事抗体制备研究。
  • 300192 天津, 中国医学科学院中国协和医科大学放射医学研究所

摘要: cTnI(心肌肌钙蛋白Ⅰ)是心肌肌钙蛋白的一种亚型,正常人血液中含量很低,当心肌细胞损伤时,cTnI在血液中的含量迅速升高。近年来随着cTnI检测方法的不断改进,cTnI已成为最具有临床价值的心肌损伤标志物之一,被广泛应用于心脏疾患的临床诊断和检测。

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