摘要:
目的 探讨99mTc-HL91-二氮杂-3,3,10,10-四甲基十二烷-2,11-二酮二肟(99mTc-HL91)乏氧显像评价鼻咽癌放疗疗效的临床价值。方法 鼻咽癌患者30例,放疗前经肘静脉注射99mTc-HL91 1110MBq后1h、4h,分别进行头颈部SPECT,用感兴趣区技术求出肿瘤组织/头皮本底(T/B)比值,放疗结束后4周按WHO标准进行放疗疗效评价。结果 ① 30例鼻咽癌患者99mTc-HL91显像1h和4h的T/B比值均值分别为1.370±0.207和1.883±0.358,具有统计学差异(t=6.794,P<0.001)。②放疗有效组与无效组的1h和4hT/B比值均值分别为1.273±0.196与1.498±0.147和1.679±0.232与2.152±0.318.也具有统计学差异。结论 99mTc-HL91显像可探测鼻咽癌病灶乏氧状态,在预测放疗疗效方面有一定的应用价值。
Abstract:
Objective To investigate the clinical value of 99mTc-4, 9-diaza-3, 3, 10, 10-tetramethyldodecan-2, 11-dione dioxime(99mTc-HL91) hypoxia imaging in detecting radiotherapy response of nasopharyngeal carcinoma. Methods Thirty patients with nasopharyngeal carcinoma who will receive radiotherapy underwent 99mTc-HL91 imaging at lh and 4 h post-injection of 99mTc-HL91. Region of interest technique was used to calculate the tumor-to-background ratios of scalp(T/B). The effects of radiotherapy were evaluated 4 weeks later by the radiotherapists according to the standard of WHO. Results ① The 99mTc-HL91 uptake ratios of T/B in thirty patients at 1 h and 4 h imaging were 1.370±0.207 and 1.883±0.358, respectively. There was a significant difference between T/B value of the two phases (t=6.794, P<0.001). ② The follow-up results demonstrated that the average T/B value at lh and 4 h phase in the group of effective radiotherapy and ineffective radiotherapy were 1.273±0.196 and 1.498±0.147, 1.679±0.232 and 2.152±0.318, respectively. There was a significant difference between T/B value of the two group. Conclusion The hypoxia status can be observed by 99mTc-HL91 imaging which has certain clinical value in forecasting the effects of radiotherapy.