α粒子辐射与基因组不稳定性

仲恒高; 童建

α粒子辐射与基因组不稳定性

仲恒高 , 童建

文章导航 > 国际放射医学核医学杂志 > 2004, 28 > 6: (267-270)

引用本文:

Citation:

α粒子辐射与基因组不稳定性

仲恒高,
童建

215007 苏州, 苏州大学放射医学与公共卫生学院
中图分类号: Q345⁺.2

Alpha-particles radiation and genomic instability

Istitute of Radiation Medicine and Public Health, Suzhou University, Suzhou 215007, China
CLC number: Q345⁺.2

摘要: α粒子照射后除了引起机体本身的可见的变化如细胞死亡、增殖、癌变,其引起的遗传损伤效应也日益受到人们的注意。越来越多的研究表明:辐射可引起基因组不稳定性的过程,使受照射细胞的应答反应传递到子代细胞中,并表现出一系列遗传学变化。基因组不稳定性的机制目前还不甚清楚,可能与旁效应、自由基、DNA修复缺陷、端粒功能失调以及基因大片段缺失等有关。
- α粒子 /
- 基因组不稳定性 /
- 旁效应 /
- 自由基 /
- 端粒
Abstract: Alpha-particles can lead to cell death, proliferation and cancerization, but genetic damage is more worth concerning. Many studies have shown that alpha-particles also cause a procedure of genomic instability and the damage can transfer to filial generations. The mechanism is not clear, maybe relate to bystander effect, free radicles, DNA repair-deficiency, telomere function disorder and gene partial or total deletion.
- alpha particles /
- genomic instability /
- bystander-effect /
- free radicals /
- telomere
本作品遵循Signature-Non-Commercial Use 4.0 International (CC BY-NC 4.0)协议

[1]	IPCS.Enviromental Health Criteria 211.Health effects of international between tobaccouse and expoure to otheragents[M].WHO.1999.57.
[2]	Christian S,Anna K,Wolfgang U,et al.Genomic instability in uranium miners after high radiation exposures[J].Int Congress Ser,2002,1225:223-227.
[3]	Muller WU,Kryscio A,Streffer C.Micronuclei in lymphocytes of uranium miners of the former Wismut SDAG[J].Cytogenet Genome Res,2004,104(1-4):295-298.
[4]	Simons JWIM.Coming of age:Dysgenitics-a theory conection induction of Persistent delayed genomic instability with disturbed cellar aging[J].Int J Radiat Biol,2000,76(11):1533-1543.
[5]	Zhou HN,Randers-Pehrson G,Waldren CA,et al.Induction of abystander mutagenic effect of α-particles in mammalian cells[J].Proc Natl Acad Sci USA,2000,97:2099-2104.
[6]	Ojima M,Hamano H,Suzuki M,et al.Delayed induction of telomere instability in normal human fibroblast cells by ionizing radiation[J].Free Radic Biol Med,2003,35(1):68-77.
[7]	吴李君,黑国庆,许安等.细胞质受照射的遗传损伤效应[J].辐射研究与辐射工艺学报,2001,19(1):40-44.
[8]	Tulard A,Hoffschir F,de Boisferon FH,et al.Persistent oxidative stress after ionizing radiation is involved in inherited radiosensitivity[J],Free Radic Biol Med.2003,35(1):68-77.
[9]	Hatsumi N,John B,Little.Bystander effect for chromosomal aberrations induced in wild-type and repair deficient CHO cells by low fluences of alpha particles[J].Mutat Res,2002,508:121-129.
[10]	Ayumi U,Seiji K,Keiji S,et al.High susceptibility to the induction of genetic instability by radiation in DNA repair-deficient cells[J].Int Congress Ser,2003,1258:261-265.
[11]	Undarmaa B,Kodama S,Suzuki K,et al.X-ray-induced telomeric instability in Atm-deficient mouse cells[J].Biochem Biophys Res Commun,2004,315(1):51-58.
[12]	Mitsuaki O,Keiji S,Seiji K,et al.Radiation-induced delayed chromosomal instability caused by large deletion[J].Int Congress Ser,2003,1258:267-271.
[13]	Lee M E,Lichtenstein E,Andrews,et al.Radon-smoking synergy:A population-based behavioral risk reduction approach[J].Prev Med,1999,29(3):222-227.
[14]	Dano L,Guilly MN,Muleris M,et al.Records.CGH analysis of radon-induced rat lung tumors indicates similaries with human lung cancers[J].Genes,Chromosomes and Cancer,2000,29(1):1-8.

[1]	朱涵能 , 程文英 . 端粒与染色体不稳定性. 国际放射医学核医学杂志, 1998, 22(5): 231-234.
[2]	孙权 , 蔡建明 , 黄越承 . 富勒烯衍生物对自由基的清除作用及其生物学效应. 国际放射医学核医学杂志, 2008, 32(5): 308-311.
[3]	穆传杰 , 周继文 , 王继先 . 基因组不稳定性与辐射致癌的分子机理. 国际放射医学核医学杂志, 1998, 22(6): 276-279.
[4]	曹毅 , 王仲文 , 沈波 . 辐射诱导的基因组不稳定性. 国际放射医学核医学杂志, 2003, 27(2): 84-86.
[5]	沈波 . 基因组不稳定性与错配修复机制. 国际放射医学核医学杂志, 2003, 27(2): 87-89.
[6]	王仲文 . 电离辐射诱发的基因组不稳定性与辐射致癌. 国际放射医学核医学杂志, 2000, 24(5): 226-230.
[7]	贾立立 , 樊飞跃 . Gadd45与基因组稳定性. 国际放射医学核医学杂志, 2009, 33(2): 105-109. doi: 10.3760/cma.j.issn.1673-4114.2009.02.013
[8]	张瑞国 , 晋建华 . 体内自由基与Graves病研究新进展. 国际放射医学核医学杂志, 2009, 33(4): 240-242,248. doi: 10.3760/cma.j.issn.1673-4114.2009.04.015
[9]	赵永良 , 吴德昌 . 端粒及端粒酶变化在肿瘤发生中的作用. 国际放射医学核医学杂志, 1997, 21(z1): 222-225.
[10]	池翠萍 . 生物学系统内检测自由基方法的研究进展及其意义. 国际放射医学核医学杂志, 2009, 33(4): 252-255. doi: 10.3760/cma.j.issn.1673-4114.2009.04.019

点击查看大图

计量

文章访问数: 1152
HTML全文浏览量: 150
PDF下载量: 2

α粒子辐射与基因组不稳定性

仲恒高
童建

215007 苏州, 苏州大学放射医学与公共卫生学院

收稿日期: 2004-09-10

关键词:

摘要: α粒子照射后除了引起机体本身的可见的变化如细胞死亡、增殖、癌变,其引起的遗传损伤效应也日益受到人们的注意。越来越多的研究表明:辐射可引起基因组不稳定性的过程,使受照射细胞的应答反应传递到子代细胞中,并表现出一系列遗传学变化。基因组不稳定性的机制目前还不甚清楚,可能与旁效应、自由基、DNA修复缺陷、端粒功能失调以及基因大片段缺失等有关。