细胞凋亡的线粒体调控机制与电离辐射

刘光伟; 龚守良

细胞凋亡的线粒体调控机制与电离辐射

刘光伟 , 龚守良

文章导航 > 国际放射医学核医学杂志 > 2003, 27 > 2: (90-93)

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细胞凋亡的线粒体调控机制与电离辐射

30021 吉林长春, 吉林大学公共卫生学院卫生部放射生物学重点实验室

作者简介: 刘光伟(1973-),男,博士研究生,主要从事电离辐射生物效应研究。;龚守良(1945-),男,教授,博士生导师,主要从事电离辐射生物效应研究。;

中图分类号: Q244;Q756

Mitochondrial control mechanism on apoptosis and ionizing radiation

MH Radiobiology Research Unit, School of Public Health, Jilin University, Changchun 130021, China
CLC number: Q244;Q756

摘要: 线粒体在外界刺激(如电离辐射)诱发细胞凋亡中起中心调控作用。各种死亡信号通过Bcl-2家族蛋白或直接诱导线粒体膜通透性增加、细胞色素c释放和caspases激活,最终引起细胞凋亡。线粒体膜通透性改变的机制,目前还不完全清楚。简要综述细胞凋亡的线粒体调控机制及电离辐射在其机制中的可能作用。
- 细胞凋亡 /
- 线粒体 /
- 调控机制 /
- 膜通透性 /
- 细胞色素c /
- 电离辐射
Abstract: Mitochondria play a major role in apoptosis triggered by many stimuli. The various death signals induce directly and indirectly (through Bcl-2 family proteins) the increase of mitochondrial membrane permeability, the release of cytochrome c and the activation of caspases. The mechanisms that lead to this permeability are not yet completely understood. Here, we review briefly the mechanisms of mitochondrial control during apoptosis and the possible effects of ionizing radiation in their mechanisms.
- apoptosis /
- mitochondria /
- control mechanism /
- permeability /
- cytochrome c /
- ionizing radiation
本作品遵循Signature-Non-Commercial Use 4.0 International (CC BY-NC 4.0)协议

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细胞凋亡的线粒体调控机制与电离辐射

作者简介:刘光伟(1973-),男,博士研究生,主要从事电离辐射生物效应研究。;龚守良(1945-),男,教授,博士生导师,主要从事电离辐射生物效应研究。

30021 吉林长春, 吉林大学公共卫生学院卫生部放射生物学重点实验室

收稿日期: 2003-01-21

关键词:

摘要: 线粒体在外界刺激(如电离辐射)诱发细胞凋亡中起中心调控作用。各种死亡信号通过Bcl-2家族蛋白或直接诱导线粒体膜通透性增加、细胞色素c释放和caspases激活,最终引起细胞凋亡。线粒体膜通透性改变的机制,目前还不完全清楚。简要综述细胞凋亡的线粒体调控机制及电离辐射在其机制中的可能作用。