ZevalinTM:一种放射免疫治疗新药
ZevalinTM: A new radioimmunotherapy agent
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摘要: 放射免疫治疗是放射性核素治疗的重要组成和研究的重点之一。ZevalinTM第一个得到FDA批准的用于治疗复发或顽固性低度恶性非霍奇金氏淋巴瘤的放射免疫治疗制剂。本文综述了该制剂的组成、治疗方案、药理作用机制、辐射剂量和临床试验结果等方面的内容。Abstract: Radioimmunotherapy is a major component of radionuclide therapy and always being the main field of re-search.ZevalinTM is the first FDA marketing approved radioimmunotherapy agent which is indicated for the treatment of relapsed or refractory low grade non-Hodgkin's lymphoma.In this review,the component,therapeutic regimen,pharmacological mechanism,radiation dosage and clinical experiment result of ZevalinTM are described respectively.
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Key words:
- radioimmunotherapy /
- non-Hodgkin's lymphoma /
- Yittrium-90 /
- CD20 antigen /
- Zevalin
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