肿瘤辐射敏感性与细胞凋亡

朱光旭; 王小华

肿瘤辐射敏感性与细胞凋亡

朱光旭 , 王小华

文章导航 > 国际放射医学核医学杂志 > 2000, 24 > 2: (78-82)

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肿瘤辐射敏感性与细胞凋亡

400038 重庆, 中国人民解放军第三军医大学全军复合伤研究所

作者简介: 朱光旭(1972-),男,贵州瓮安人,第三军医大学全军复合伤研究所生物化学与分子生物学研究室检验技师,硕士研究生,主要从事辐射对肿瘤细胞信号转导影响的研究;王小华(1972-),女,重庆忠县人,第三军医大学全军复合伤研究所生物化学与分子生物学研究室检验技师,硕士研究生,主要从事辐射对肿瘤细胞信号转导影响的研究。;

中图分类号: R818.03

Tumor radiosensitivity and apoptosis

Institute of Combined Injury, Third Military Medical University, Chongqing 400038, China
CLC number: R818.03

摘要: 辐射敏感性是肿瘤细胞复杂的生物学现象,在辐射诱导的细胞反应中具有不同的组织细胞类型特异性。肿瘤瘤射敏感性与辐射诱导的细胞凋亡密切相关,并受P53及其相关蛋白、Bcl-2基因家族蛋白、Fas及神经鞘磷脂-神经酰胺介导的信号途径、caspases级联反应等调控。
- 辐射敏感性 /
- 细胞凋亡 /
- 信号途径 /
- 基因表达调控
Abstract: Radiosensitivity is a complex phenomenon in tumor cells and there exist special biological effects in different types of tissues' cells in inadiation-induced cell responses. Tumor radiosentivity is tightly connected with irradiation-induced apoptosis and is regulated by many protein products of apoptosis-related genes such as p53 and related proteins, Bcl-2 gene family proteins, Fas and sphingomyelin/ceramide-mediated signalling pathways and caspases cascade etc.
- radiosensitivity /
- apoptosis /
- signaling pathway /
- regulation of gene expression
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[1]	Castro MA, Schwartsmann G, Bernard EA, et al.Phenotyp emodulation of cellular UV-sensitivity[J].Cancer Lett, 1999, 145(1-2):65~72.
[2]	Maity A, Kao GD, Muschel RJ, et al. Potential molecular targets for manipulating the radiation response[J]. Int J Radiat Oncol Biol Phys, 1997, 37(3):639~653.
[3]	Evan G, Littlewood J. A matter of life and cell death[J]. Science, 1998, 281(5381):1317~1322.
[4]	McConkey DJ, Zhivotov sky B, Orrenius S. Apoptosis-molecular mechanisms and biomedical implications[J]. Mol Aspects Med, 1996, 17(1):1~110.
[5]	Li P, Eijhawan D, Budihardjo I, et al. Cytochrome C and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptosis protease cascade[J].Cell, 1997, 91(4):949~957.
[6]	Olive PL, Durand RD. Apoptosis:An indicator of radiosensitivity in virto[J]. Int J Radiat Biol, 1997, 71(6):695~707.
[7]	Dubray B, Breton C, Delic J, et al. In vitro radiation-induced apoptosis and tumour response to radiotherapy treated by low-dose irradiation[J]. Int J Radiat Biol, 1997, 72(6):759~760.
[8]	Broaddus WC, Liu Y, Steele LL, et al. Enhanced radiosensitivity of malignant glioma cells after adenoviral p53 transduction[J]. J Neurosurg, 1999,91(6):997~1004.
[9]	DiBiase SJ, Guan J, Curran WJ, et al. Repair of DNA double-strand breaks and radiosensitivity to killing in an isogenic group of p53 mutant cell line[J]. Int J Radiat Oncol Biol Phys, 1999, 45(3):743~751.
[10]	Chiarugi V, Magneli L, Cinelli M. Role of p53 mutations in the radiosensitivity status of tumor cells[J]. Tumor, 1998, 84(5):517~520.
[11]	Kariya S, Ogawa Y, Yoshida S, et al. X-irradiation enhances the expression of Bcl-2 in HL-60 cells:The resulting effects on apoptosis and radiosensitivity[J].Int J Mol Med, 1999, 3(2):145~152.
[12]	Reed JC. Bcl-2 family proteins[J]. Oncogene, 1998, 17(25):325~336.
[13]	Kroemer G. The proto-oncogene Bcl-2 and its role in regulation apoptosis[J]. Nat Med, 1997, 3(6):614~620.
[14]	Okalchi K, Wang LH, Sasaki J, et al. A point mutation of human p53, which was detected as a mutation by a yeast functional assay, led to apoptosis but not P21 waf-1/cip-1/sdil expression in response to ionizing irradiation in human osteosarcoma cell line[J]. Int J Radiat Oncol Biol Phys, 1999, 45(4):975~980.
[15]	Belka C, Keinrich V, Marimip K, et al. Ionizing radiation and the activation of caspase-8 in highly apoptosis-sensitive lymphoma cells[J]. Int J Radiat Biol, 1999, 75(10):1257~1264.
[16]	Watters D. Molecular mechanisms of ionizing radiation-induced apoptosis[J]. Immunol Cell Biol,1999, 77(3):263~271.
[17]	Burri SH, Kim CN, Fang G, et al. "Loop" domain deletional mutant of Bcl-xL is as effective as p29Bcl-xL in inhibiting radiation-induced cytosolic accumulation of cytochrome C (cyt C), caspase-3 activity, and apoptosis[J]. Int J Radiat Oncol Biol Phys, 1999, 43(2):423~430.
[18]	Jurgensmeier JM, Xie Z, Dereraux Q, et al. Bax directly induced release of cytochrome C from isolated mitochondria[J]. Proc Natl Acad Sci USA, 1998, 95(9):4997~5002.

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