放射性脑损伤发病机制及免疫系统改变的研究
Study of pathogenesis and the change of immune system of radiation brain injury
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摘要: 放射性脑损伤是头颈部肿瘤放射治疗后的一种严重并发症,本文从放射性脑损伤发病机制及电离辐射引起免疫系统改变的基础上推断放射性脑损伤可能引起的免疫系统改变。Abstract: Radiation brain injury is a severe comphcation of the pate tumour after radiotherapy. Review the pathogenesis of radiation brain injury and ion irradiation and the change of immune system then conclude the change of immune system that radiation brain injury can cause.
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Key words:
- Brain injury /
- Radiation injury /
- Immune system
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[1] 唐亚梅,邢诒刚,吕瑞妍,等.大鼠脑照射后学习记忆力下降及脑损伤修复的研究.中华放射医学与防护杂志,2004,24(2):130-131.
[2] Romero AA,Gross SR,Cheng KY,et al.An age-related increase in resistance to DNA damaged-induced apoptotic cell death is associated with development of DNA repair mechanisms.J Neurochem,2003,84(6):1275-1287. [3] Gobbel GT,Chan PH.Neuronal death is an active,caspasedependent process after moderate but not severe DNA damage.J Neurochem,2001,76(2):712-720. [4] 张燕,陈肖华.中枢神经系统辐射损伤的细胞与分子机制研究进展.国外医学·放射医学核医学分册,2004,28(1):41-44.
[5] Tofilon PJ,Fike JR.The radioresponse of the central nerous system:a dynamic process.Radiat Res,2000,153(3):357-370. [6] 高荣莲,陈肖华.星形胶质细胞的电离辐射损伤及修复作用.国外医学·放射医学核医学分册,2004,28(1):37-40.
[7] Kutita H,Kawahara N,Asai A,et al.Radiation-induced apoptosis of oligodendrocytes in the adult rat brain.Neurol Res,2001,23(8):869-874. [8] Cammer W.Effects of TNF alpha on immatuare and mature oligodendrocytes and their progenitors in vitro.Brain Res,2000,864(2):213-219. [9] Pena LA,Fuks Z,Kolesnick RN.Radiation-induced apoptosis of endothelial cells in the murine central nervous system:protection by fibroblast growth factor and sphingomyelinsae deficiency.Cancer Res,2000,60(2):321-327. [10] Kimura T,Sako K,Tohyama Y,et al.Diagnosis and treatment of progressive space-occupying radiation necrosis following steretactic radiosurguery for brain metastasis:value of proton magnetic resonance spectroscopy.Acta Neurochir (Wien),2003,145(7):557-564. [11] 刘强.放射性脑损伤研究现状.国外医学·放射医学核医学分册,2004,28(4):178-181.
[12] Torihata H,Ishikawa F,Okada Y,et al.Irradiation up-regulates CD80 expression through two different mechanisms in spleen B cells,B lymphoma cells,and dendritic cells.Immuunology,2004,112(2):219-227. [13] Cao MD,Chen ZD,Xing Y.Gamma irradiation of human dendritic cells influences proliferation and cytokine profile of T cells in autologous mixed lymphocyte reaction.Cell Biol Int,2004,28(3):223-228. [14] Hong JH,Chiang CS,Tsao CY,et al.Can short-term administration of dexamethasone abrogate radiation-induced acute cytokine gene response in lung and modify subsequent molecular response?.Int J Radiat Oncol Biol Phys,2001,51(2):296-303. [15] Kim SH,Lim DJ,Chung YG,et al.Expression of TNF-α and TGF-β1 in the rat brain after a single high-does irradiation.J Korean Med Sci,2002,17(2):242-248.
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