Ku蛋白与DNA修复

杨青山; 樊飞跃

Ku蛋白与DNA修复

杨青山 , 樊飞跃

文章导航 > 国际放射医学核医学杂志 > 2008, 32 > 1: (40-43)

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Ku蛋白与DNA修复

杨青山^,,
樊飞跃

300192 天津, 中国医学科学院中国协和医科大学放射医学研究所生化应急室

通讯作者: 杨青山, yqslll@yahoo.com.cn ;

中图分类号: Q691

Ku protein and DNA repair

YANG Qing-shan^,,
FAN Fei-yue

Departmant of Biochemical Emergoncy, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300192, China

Corresponding author: YANG Qing-shan, yqslll@yahoo.com.cn ;

CLC number: Q691

摘要: 电离辐射易引起DNA双链断裂(DSB),Ku蛋白作为异二聚体,主要参与非同源末端联接修复DSB。Ku蛋白在维持端粒结构发挥至关重要的作用。在人的不同肿瘤中,Ku蛋白有着异常表达,且Ku蛋白的表达和功能与肿瘤放化疗抵抗有关。通过抑制Ku蛋白可增强放化疗敏感性。因此,Ku蛋白可作为放化疗增敏的靶点。
- DNA修复 /
- 辐射耐受性 /
- 肿瘤
Abstract: Ionizing radiation can cause double strand break (DSB), Ku protein as a heterologous dimmer; mainly join in non-homologous end-joining repair pathway. Ku protein plays a crucial role in maintaining telomere structure. There is an abnormal expression of Ku protein in human different tumors. The expression and function of Ku protein is relate to resistance of tumor radiotherapy and chemotherapy. Inhibition of Ku protein can enhance the sensitivity of radiotherapy and chemotherapy. Therefore, Ku protein can be used as target of enhancement of radiotherapy and chemotherapy.
- DNA repair /
- Radiation tolerance /
- Neoplasm
本作品遵循Signature-Non-Commercial Use 4.0 International (CC BY-NC 4.0)协议

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Ku蛋白与DNA修复

杨青山^,
樊飞跃

通讯作者: 杨青山, yqslll@yahoo.com.cn;

300192 天津, 中国医学科学院中国协和医科大学放射医学研究所生化应急室

收稿日期: 2007-09-10

关键词:

DNA修复 /
辐射耐受性 /
肿瘤

摘要: 电离辐射易引起DNA双链断裂(DSB),Ku蛋白作为异二聚体,主要参与非同源末端联接修复DSB。Ku蛋白在维持端粒结构发挥至关重要的作用。在人的不同肿瘤中,Ku蛋白有着异常表达,且Ku蛋白的表达和功能与肿瘤放化疗抵抗有关。通过抑制Ku蛋白可增强放化疗敏感性。因此,Ku蛋白可作为放化疗增敏的靶点。