延迟相心肌缺血预适应机制的核医学方法研究

王淑侠; 裴著果

王淑侠 , 裴著果

文章导航 > 国际放射医学核医学杂志 > 2001, 25 > 1: (1-3)

引用本文:

Citation:

延迟相心肌缺血预适应机制的核医学方法研究

110001 辽宁沈阳, 中国医科大学附属第二临床学院核医学科

作者简介: 王淑侠(1965-)女,辽宁沈阳人,中国医科大学第二临床学院核医学科博士研究生,主要从事核心脏病学研究。;

中图分类号: R817.4

Nuclear medicine methods in the field of studying the mechanisms of delayed phase of myocardial preconditioning

WANG Shu-xia,

Department of Nuclear Medicine, No.2, Affiliated Hospital, China Medical University, Liaoning, Shengyang 110001, China
CLC number: R817.4

摘要: 心肌缺血预适应是目前已知心脏保护作用最为强大的、心脏固有的自我保护机制,阐明预适应机制是临床合理安全地利用预适应保护作用的前提。延迟相预适应机制目前主要有NO(一氧化氮)假说、自由基机制、保护性蛋白的作用和ATP敏感性钾通道作用等。引入³H-亮氨酸,利用液闪技术,已直接从因果关系上证实保护性蛋白在预适应保护中的作用。利用SPECT可无损伤地在活体内显示预适应心肌特点,而PET则可进行预适应心肌代谢改变与心功能关系的研究。
- 缺血预适应 /
- 心肌 /
- ³H-亮氨酸 /
- 单光子发射断层显像 /
- 正电子发射断层显像
Abstract: Ischemic preconditioning is the intrinsic and most potently myocardial protection we know now. To illu-minate its mechanism is the foundation of rational theraputic application. Nowadays there are some theories about delayed phase of preconditioning such as nitric oxide hypothesis, free radical mechanisms, protective protein syn-thesis and opening of AT P-sensitive potassium channels. By incorporation ³H-leucine, using liquid scintillation counter, we now know there was protective protein synthesis during preconditioning. SPECT could study the char-acteristics of preconditioned myocardium in vivo, and PET might further show the metabolism, energy consumption and its relationship to myocardium dysfunction.
- ischemic preconditioning /
- myocardial /
- ³H-leucine /
- single photon emission computerized tomgraphy /
- positron emission tomography
本作品遵循Signature-Non-Commercial Use 4.0 International (CC BY-NC 4.0)协议

[1]	Meldrum DR.Mechanisms of cardialc precondition-ing:ten years after the discovery of ischemic precondi-tioning[J].J Surg Res,1997,73(1):1-13.
[2]	Nagao K,Satou K,Arima K,et al.Relationship be-tween preinfarction angina and time interval to reper-fusion with thrombolytic therapy in acute myocardial infartion[J].Jpn Circ J,1997,61(10):843-849.
[3]	Tomoda H,Aoki N.Comparision of protective effects of preinfarction angina pectoris in aucte myocardial in-farction treated by thrombolysis versus by primary coronary angioplasty with stenting[J].Am J Cardiol,1999,84(6):621-625.
[4]	Ishihara M,Sato H,Tateishi H,et al.Implications of prodromal angina pectoris in anterior wall acute my-ocardial infarction:acute angiographic findings and long-term prognosis[J].J Am Coll Cardiol,1997,30(4).970-975.
[5]	Dana A,Baxter GF,Walker JM,et al.Prolonging the delayed phase of myocardial protection:repetitive adenosine A1 recepter activation maintains rabbit my-ocardium in a preconditioned state[J].J Am Coll Car-diol,1998,31(5):1142-1149.
[6]	Meldrum DR,Cleveland JC Jr,Rowland RT,et al.Early and delayed preconditioning:differential mecha-nisms and additive protection[J].Am J Physiol,1997,273(2 Pt 2):H725-H733.
[7]	Bolli R,Bhatti ZA,Tang XL,et al.Evidence that late preconditioning against myocardial stunning in conscious rabbits is triggered by the generation of ni-tric oxide[J].Circ Res,1997,81(1):42-52.
[8]	Ping P,Takano H,Zhang J,et al.Isoform-selective activation of protein kinase C by nitric oxide in the heart of conscious rabbits:a signaling mechanism for both nitric oxide-induced and ischemia-induced precon-ditioning[J].Circ Res,1999,84(5):587-604.
[9]	Xuan YT,Tang XL,Banerjee S,et al.Nuclear factor-kappa B plays an essential role in the late phase of ischemic preconditioning in conscious rabbits[J].Circ Res,1999,84(9):1095-1109.
[10]	Jones W K,Flaherty M P,Tang XL,et al.Ischemic preconditioning increases iNO S transcript levels in conscious rabbits via a nitric oxide-dependent mecha-nism[J].J Mol Cell Cardiol,1999,31(8):1469-1481.
[11]	Imagawa J,Yellon DM,Baxter GF.Pharmacological evidence that inducible nitric oxide synthase is a media-tor of delayed preconditioning[J].Br J Pharmacol,1999,126(3):701-708.
[12]	Rizvi A,Tang XL,Qiu Y,et al.Increased protein synthesis is necessary for the development of late pre-conditioning against myocardial stunning[J].Am J Physiol,1999,277(3 Pt 2):H874-H884.
[13]	Su CY,Chong KY,Owen OE,et al.Constitutive and inducible hsp 70s are involved in oxidaive resistance e-voked by heat shock or ethanol[J].J Mol Cell Cardi-ol,1998,30(3):587-598.
[14]	Yamashita N,Hoshida S,Taniguchi N,et al.A "sec-ond window of protection" occurs 24h after ischemic preconditioning in the rat heart[J].J Mol Cell Cardi-ol,1998,30(6):1181-1189.
[15]	Dana A,Jonassen AK,Yamashita N,et al.Adeno-sine A(1) receptor activation indues delayed precondi-tioning in rats mediated by manganese superoxide dis-mutase[J].Circulation,2000,101(24):2841-2848.
[16]	Baghelai K,Graham LJ,Wechsler AS,et al.Delayed myocardial preconditioning by alphal-adrenoceptors in-volves inhibition of apoptosis[J].J Thorac Cardiovasc Surg,1999,117(5):980-986.
[17]	Bernardo NL,D'Angelo M,Okubos,et al.Delayedischemic preconditioning is mediated by opening ofATP-sensitive potassium channels in the rabbit heart[J].Am J Physiol,1999,276(4 Pt 2):H1323-H1330.
[18]	Bernardo N L,Okubo S,Maaieh MM,et al.Delayed preconditioning with adenosine is mediated by opening of AT P-sensitive K (+) channels in rabbit heart[J].Am J Physiol,1999,277(1 Pt 2):H128-H135.
[19]	KhawBA.The current role of infarct avid imaging[J].Semin Nucl Med,1999,(3):259-270.

[1]	郭万华 . 统计参数图在PET和SPECT脑功能显像中的应用. 国际放射医学核医学杂志, 2002, 26(1): 7-11.
[2]	唐刚华 . 基因表达正电子发射断层显像. 国际放射医学核医学杂志, 2001, 25(6): 241-245.
[3]	石洪成 . 心肌显像病人所致伪影的辨析及其对策研究. 国际放射医学核医学杂志, 2002, 26(1): 15-17.
[4]	赵倩 , 李娟 . 糖尿病冠状动脉粥样硬化性心脏病的发病机制及核素心肌灌注显像的研究进展. 国际放射医学核医学杂志, 2007, 31(3): 132-135.
[5]	程旭 . 心肌灌注显像常见伪影分析. 国际放射医学核医学杂志, 2004, 28(3): 117-120.
[6]	周惠君 , 董萍 , 沈国华 , 李林 . ¹¹C-蛋氨酸PET/CT显像在脑胶质瘤中的应用价值. 国际放射医学核医学杂志, 2015, 39(2): 161-164. doi: 10.3760/cma.j.issn.1673-4114.2015.02.013
[7]	苏瑶 , 王丽 , 刘爱军 , 杨敏福 . Al¹⁸F-NOTA-FAPI PET/CT显像在轻链型心脏淀粉样变中的诊断价值. 国际放射医学核医学杂志, 2024, 48(1): 15-21. doi: 10.3760/cma.j.cn121381-202309001-00382
[8]	刘刚 , 吴华 , 吴立兵 , 李伏燕 , 裴之俊 , 陈宇 . ⁹⁹Tc^m-HL91 SPECT探测缺血存活心肌的初步应用研究. 国际放射医学核医学杂志, 2009, 33(2): 73-75. doi: 10.3760/cma.j.issn.1673-4114.2009.02.003
[9]	王明芳 . 放射性示踪剂在脑功能PET显像中的应用. 国际放射医学核医学杂志, 2001, 25(6): 246-249.
[10]	李薇 , 张宗耀 , 韩凯 , 王小迪 , 孙晓昕 . ⁹⁹Tc^m-PYP 双时相平面显像和断层显像在诊断转甲状腺素蛋白相关心脏淀粉样变中的临床应用价值. 国际放射医学核医学杂志, 2024, 48(1): 22-29. doi: 10.3760/cma.j.cn121381-202308025-00387
[11]	康玉国 . 分化型甲状腺癌¹⁸F-FDG PET显像的临床应用. 国际放射医学核医学杂志, 2000, 24(6): 264-267.
[12]	王荣福 . 多巴胺能神经递质及受体显像的临床研究和应用进展. 国际放射医学核医学杂志, 2000, 24(2): 59-62.

点击查看大图

计量

文章访问数: 995
HTML全文浏览量: 113
PDF下载量: 3

延迟相心肌缺血预适应机制的核医学方法研究

作者简介:王淑侠(1965-)女,辽宁沈阳人,中国医科大学第二临床学院核医学科博士研究生,主要从事核心脏病学研究。

110001 辽宁沈阳, 中国医科大学附属第二临床学院核医学科

收稿日期: 2000-09-04

关键词:

摘要: 心肌缺血预适应是目前已知心脏保护作用最为强大的、心脏固有的自我保护机制,阐明预适应机制是临床合理安全地利用预适应保护作用的前提。延迟相预适应机制目前主要有NO(一氧化氮)假说、自由基机制、保护性蛋白的作用和ATP敏感性钾通道作用等。引入³H-亮氨酸,利用液闪技术,已直接从因果关系上证实保护性蛋白在预适应保护中的作用。利用SPECT可无损伤地在活体内显示预适应心肌特点,而PET则可进行预适应心肌代谢改变与心功能关系的研究。