硼中子俘获治疗的辐射场特点与剂量估算

王丹

硼中子俘获治疗的辐射场特点与剂量估算

王丹

文章导航 > 国际放射医学核医学杂志 > 2002, 26 > 2: (87-89)

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硼中子俘获治疗的辐射场特点与剂量估算

王丹

300192 天津, 中国医学科学院中国协和医科大学放射医学研究所

作者简介: 王丹(1977-),女,黑龙江呼兰人,硕士研究生,主要从事外照射器官吸收剂量的研究。;

中图分类号: T144.1;R730.55

Characteristics of radiation field and dosimetry of born neutron capture therapy

WANG Dan

Institution of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300192, China
CLC number: T144.1;R730.55

摘要: BNCT(硼中子俘获治疗)基于这样一种思想:¹⁰B的载体化合物会优先选择癌细胞作为靶而后与热中子反应,进而产生高能、短射程裂变产物α粒子和Li粒子。它是一种双重的靶向治疗方法。BNCT的治疗效果依赖于两个主要因素:源于¹⁰B(n,α)⁷Li核反应的高LET(传能线密度)粒子的生物效应和在靶细胞及其特异区域内的硼沉积。本文总结和探讨了BNCT的发展概况、辐射场的特点以及吸收剂量的计算方法。
- 硼中子俘获治疗 /
- 中子束 /
- 剂量测定
Abstract: Boron neutron capture therapy (BNCT) is based on the nuclear reaction that occurs when boron-10 is irradiated with low-energy thermal neutrons to yield alpha particles and recoiling lithium-7 nuclei which have high energy and shortrange. BNCT is a binary approach:a boron-labeled compound is administered that delivered high concentration of ¹⁰B of the target tumor relative to the surrounding tissues. The therapeutic efficiency of BNCT is depended upon RBE and LET of the reaction and particles and the boron selectivity to cancerous cells. The development of BNCT, characteristic of radiation fields and calculations of energy deposition are described in this paper.
- boron neutron capture therapy /
- neutron beam /
- dosimetry
本作品遵循Signature-Non-Commercial Use 4.0 International (CC BY-NC 4.0)协议

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硼中子俘获治疗的辐射场特点与剂量估算

王丹

作者简介:王丹(1977-),女,黑龙江呼兰人,硕士研究生,主要从事外照射器官吸收剂量的研究。

300192 天津, 中国医学科学院中国协和医科大学放射医学研究所

收稿日期: 2001-11-15

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摘要: BNCT(硼中子俘获治疗)基于这样一种思想:¹⁰B的载体化合物会优先选择癌细胞作为靶而后与热中子反应,进而产生高能、短射程裂变产物α粒子和Li粒子。它是一种双重的靶向治疗方法。BNCT的治疗效果依赖于两个主要因素:源于¹⁰B(n,α)⁷Li核反应的高LET(传能线密度)粒子的生物效应和在靶细胞及其特异区域内的硼沉积。本文总结和探讨了BNCT的发展概况、辐射场的特点以及吸收剂量的计算方法。