放射抑制再狭窄的细胞及分子机制

仁晓庆

放射抑制再狭窄的细胞及分子机制

仁晓庆

文章导航 > 国际放射医学核医学杂志 > 2000, 24 > 2: (89-92)

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Citation:

放射抑制再狭窄的细胞及分子机制

仁晓庆

200001 上海, 上海第二医科大学附属仁济医院核医学科

作者简介: 任晓庆(1963-),男,山东菏泽人,上海第二医科大学附属仁济医院核医学科主治医师,博士研究生,主要从事放射抑制再狭窄方面的研究。;

基金项目:
国家自然科学基金资助项目(39970221)
中图分类号: Q274

Cellular and Molecular mechanisms of radiation for the inhibition of restenosis

REN Xiao-qing

Renji Hospital, Shanghai Second Medical University, Shanghai, 200001, China
CLC number: Q274

摘要: 放射抑制再狭窄的机制是多方面的。它既可诱导血管平滑肌细胞有丝分裂周期阻滞,抑制平滑细胞分裂及增殖,又可直接诱导平滑肌细胞凋亡,还可抑制单核/巨噬细胞及各种生长因子,阻止再狭窄过程听起始因素。血管内放射导致细胞死亡的主要形式凋亡,电离辐射预防再狭窄的主要机制是平滑肌细脑的增殖抑制。
- 电离辐射 /
- 基因调控 /
- 细胞凋亡 /
- 细胞周期阻滞
Abstract: The prevention of restenosis by radiation exists a lot of mecranisms, including smooth muscle cells (SMCs) division cycles arrests, inhibition of SMCs proliferation, SMCs apoptosis,inhibition of macrophage/monocyte and cytokines. Apoptosis is a major style of cell death induced by endovascular radiation. The inhibition of SMCs proliferation induced by radiation is a main mechanism for prevention of restenosis.
- radiation /
- gene regulation /
- apoptosis /
- cell cycles arrest
本作品遵循Signature-Non-Commercial Use 4.0 International (CC BY-NC 4.0)协议

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