核素炎症显像的研究进展

陈璟; 吴华

核素炎症显像的研究进展

陈璟 , 吴华

文章导航 > 国际放射医学核医学杂志 > 2003, 27 > 3: (107-110)

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Citation:

核素炎症显像的研究进展

陈璟,
吴华

430030 武汉, 华中科技大学同济医学院附属同济医院核医学科

作者简介: 陈璟(1973-),女,主治医生,博士研究生,主要从事临床核医学研究。;吴华(1958-),男,主任医师,教授,博士生导师。;

中图分类号: R817.4

The development of radionuclide imaging of infection and inflammation

CHEN Jing,
WU Hua

Department of Nuclear Medicine, Tongji Hospital, Huazhong University of Science and Technology, Hubei Wuhan 430030, China
CLC number: R817.4

摘要: 核素炎症显像是早期检测炎性病灶的一项重要手段。核素标记白细胞显像探测急、慢性炎症病灶灵敏度高,特异性强,素有"金标准"之称,但其标记过程复杂,又易发生交叉感染。一些替代性炎症显像的研究已获发展。本文简述了目前主要的核素炎症显像的特点和研究进展。
- 核素显像 /
- 感染与炎症 /
- 放射性药物
Abstract: Radionuclide imaging of infection and inflammation is a powerful diagnostic tool in the management of patients with infectious or inflammatory disease. Because of the excellent performance, radiolabeled leukocytes have become a gold standard nuclear medicine technique to image infection and inflammation. However, the preparation of this radiopharmaceutical is laborious and requires the handling of potentially contaminated blood. A few other methods are available that could be used instead of radiolabeled leukocytes imaging. In this article, the characteristics and diagnostic potential of established and experimental scintigraphic methods of infection and inflammation are reviewed.
- scintigraphic imaging /
- imfection and inflammation /
- radiopharmaceuticals
本作品遵循Signature-Non-Commercial Use 4.0 International (CC BY-NC 4.0)协议

[1]	Kipper SL, Rypins EB, Evans DG, et al. Neutrophil-specific ⁹⁹Tc^m-anti-CD15 monoclonal antibody imaging for diagnosis of equivocal appendicitis[J]. J Nucl Med, 2000, 41(3):449-455.
[2]	Jamar F, Chapman PT, Manicourt DH, et al. A comparison between ¹¹¹In-anti-E-selection mAb and ⁹⁹Tc^m-labelled human non-specific immunoglobulin in radionuclide imaging of rheumatoid arthritis[J]. Br J Radiol, 1997, 70(833):473-481.
[3]	Dams ET, Nijhof MW, Oyen WJG, et al. Scintigraphic evaluation of experimental chronic osteomyelitis [J]. J Nucl Med,2000,41(5):896-902.
[4]	Dams ET, Oyen WJG,Boeman OC,et al.⁹⁹Tc^m-PEG-lipo-somes for the scintigraphic detection of infection and inflammation:Clinical evaluation[J].J Nucl Med, 2000, 41(4):622-630.
[5]	Brouwers AH,DeJong DJ,Dams ETM,et al.⁹⁹Tc^m-PEG-liposomes for the evaluation of colitis in Crohn's disease[J]. J Drug Targeting, 2000, 8(4):225-233.
[6]	Babich JW, Dong Q, Graham W, et al. A novel high affinity chemotactic peptide antagonist for infection imaging[J]. J Nucl Med, 1997, 38(2):268.
[7]	Caveliers V, Goodbody AE, Tran LL, et al. Evaluation of ⁹⁹Tc^m-RP128 as a potential inflammation imaging agent; Human dosimetry and first clinical results [J]. J Nucl Med, 2001, 42(1):154-161.
[8]	Barrera P, Van der Laken CJ, Boerman OC, et al. Localization of ¹²³I-IL-1ra in affected joints in patients with rheumatic arthritis[J]. Rheumatology, 2000, 39(8):870-874.
[9]	Van der Laken CJ, Boerman OC, Oyen WJG, et al. Radio-labeled Interleukin-8:Scintigraphic detection of infection within a few hours[J]. J Nucl Med, 2000, 41(3):463-469.
[10]	Rennen HJJM, Boerman OC, Oyen WJG, et al. Specific and rapid scintigraphic detection of infection with ⁹⁹Tc^m-Interleukin-8[J].J Nucl Med, 2001, 42(1):117-123.
[11]	Palestro CJ, Tomas MB, Bhargava KK, et al. Tc-99m P483H for imaging infection:phase 2 multicenter trial results[J]. J Nucl Med, 1999, 40(5 suppl):15p.
[12]	Hall AV, Solanki KK, Vinjamuri S, et al. Evaluation of the efficacy of ⁹⁹Tc^m-infection a novel agent detecting sites of infection[J]. J Clin Pathol, 1998, 51(3):215-219.
[13]	Welling MM, Nibbering PH, Paulusma-Annema A, et al. Imaging of bacterial infections with ⁹⁹Tc^m-labeled human neutrophil peptide-1[J]. J Nucl Med, 1999, 40(12):2073-2080.
[14]	Welling MM, Paulusma-Annema A, Balter HS, et al. Technetium-99m labeled antimicrobial peptides discriminate between bacterial infections and sterile inflammations[J]. Eur J Nucl Med, 2000, 27(3):292-301.
[15]	Kalicke T, Schmitz A, Risse JH, et al. Fluorine-18 fluo-rodeoxyglucose PET in infections bone diseases. Results of histologically confirmed cases[J]. Eur J Nucl Med, 2000, 27(5):524-528.
[16]	Stumpe KD, Dazzi H, Schaffner A, et al. Infection imaging using whole-body FDG-PET[J]. Eur J Nucl Med, 2000, 27(7):822-832.
[17]	Zhuang H, Duarte PS, Pourdehnad M, et al. The promising role of ¹⁸F-FDG PET in detecting infected lower limb prosthesis implants[J]. J Nucl Med, 2001, 42(1):44-47.

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[9]	钟建国 . 药物-放射性药物相互作用. 国际放射医学核医学杂志, 1997, 21(4): 160-165.
[10]	钟建国 , 夏振民 , 王思理 . 美国PET放射性药物的生产和质量控制管理. 国际放射医学核医学杂志, 1999, 23(5): 198-202.