电离辐射诱导的DNA甲基化模式改变及其在辐射致癌机制研究中的意义

石大伟; 赵永成

石大伟 , 赵永成

文章导航 > 国际放射医学核医学杂志 > 2006, 30 > 4: (240-243)

引用本文:

Citation:

电离辐射诱导的DNA甲基化模式改变及其在辐射致癌机制研究中的意义

石大伟^,,
赵永成

300192 天津, 中国医学科学院中国协和医科大学放射医学研究所生物学研究室

通讯作者: 石大伟, davidstone340@yahoo.com ;

中图分类号: Q691.5

Radiation-induced DNA methylation profile changes and its impact on mechanisms of radiation carcinogenesis

SHI Da-wei^,,
ZHAO Yong-cheng

Department of Biology, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300192, China

Corresponding author: SHI Da-wei, davidstone340@yahoo.com ;

CLC number: Q691.5

摘要: 越来越多的研究已经表明,表观遗传机制在癌症发生发展中扮演了非常重要的角色,但是对于辐射致癌的表观遗传机制的研究仅刚刚起步。本文介绍了表观遗传和一种重要的表观遗传标志——DNA甲基化的相关概念,并综述了近年来人们对电离辐射诱导的DNA甲基化模式改变的研究以及DNA甲基化模式改变在辐射致癌机制研究中的意义。
- 肿瘤,辐射性 /
- DNA甲基化 /
- 表观遗传
Abstract: More and more evidence has been accumulated to indicate that epigenetic mechanisms play a important role in carcinogenesis. However, the studies on epigenetic mechanisms of radiation carcinogenesis are at their dawn. Here the related concepts of DNA methylation and epigenetics were introduced, and summarized the studies on radiation-induced DNA methylation changes in recent years and its meaning to radiation carcinogenesis.
- Neoplasms, radiation-induced /
- DNA methylation /
- Epigenetics
本作品遵循Signature-Non-Commercial Use 4.0 International (CC BY-NC 4.0)协议

[1]	Wu C,Morris JR.Genes,genetics,and epigenetics:a correspondence.Science,2001,293(5532):1103-1105.
[2]	薛开先.肿瘤表遗传学研究的进展.国外医学遗传学分册,2003,26(1):1-5.
[3]	Feinberg AP.Cancer epigenetics takes center stage.Proc Natl Acad Sci USA,2001,98(2):392-394.
[4]	Hermann A,Gowher H,Jeltsch A.Biochemistry and biology of mammalian DNA methyltransferases.Cell Mol Life Sci,2004,61(19-20):2571-2587.
[5]	Poirier LA.The effects of diet,genetics and chemicals on toxicity and aberrant DNA methylation:an introduction.J Nutr,2002,132(8 Suppl):2336S-2339S.
[6]	Laird PW.The power and the promise of DNA methylation markers.Nat Rev Cancer,2003,3(4):253-266.
[7]	Kalinich JF,Catravas GN,Snyder SL.The effect of gamma radiation on DNA methylation.Radiat Res,1989,117(2):185-197.
[8]	Pogribny I,Raiche J,Slovack M,et al.Dose-dependence,sex- and tissue-specificity,and persistence of radiation-induced genomic DNA methylation changes.Biochem Biophys Res Commun,2004,320(4):1253-1261.
[9]	Kovalchuk O,Burke P,Besplug J,et al.Methylation changes in muscle and liver tissues of male and female mice exposed to acute and chronic low-dose X-ray-irradiation.Mutat Res,2004,548(1-2):75-84.
[10]	Koturbash I,Pogribny I,Kovalchuk O.Stable loss of global DNA methylation in the radiation-target tissue-a possible mechanism contributing to radiation carcinogenesis?.Biochem Biophys Res Commun,2005,337(2):526-533.
[11]	Raiche J,Rodriguez-Juarez R,Pogribny I,et al.Sex- and tissuespecific expression of maintenance and de novo DNA methyltransferases upon low dose X-irradiation in mice.Biochem Biophys Res Commun,2004,325(1):39-47.
[12]	Pogribny I,Koturbash I,Tryndyak V,et al.Fractionated low-dose radiation exposure leads to accumulation of DNA damage and profound alterations in DNA and histone methylation in the murine thymus.Mol Cancer Res,2005,3(10):553-561.
[13]	Romanenko A,Morell-Quadreny L,Lopez-Guerrero JA,et al.P16INK4A and pl5INK4B gene alteration associated with oxidative stress in renal cell carcinomas after the chernobyl accident (pilot study).Diagn Mol Pathol,2002,11(3):163-169.
[14]	Duthie SJ,Narayanan S,Blum S,et al.Folate deficiency in vitro induces uracil misincorporation and DNA hypomethylation and inhibits DNA excision repair in immortalized normal human colon epithelial cells.Nutr Cancer,2000,37(2):245-251.
[15]	Pogribna M,Pogribny IP,James SJ.DNA lesions induced by folate/methyl deficiency in vitro precede DNA hypomethylation in human lymphocytes.FASEB J,1999,13:A1452.
[16]	Cerda S,Weitzman SA.Influence of oxygen radical injury on DNA methylation.Mutat Res,1997,386(2):141-152.
[17]	Huang L,Snyder AR,Morgan WF.Radiation-induced genomic instability and its implications for radiation carcinogenesis.Oncogene,2003,22(37):5848-5854.
[18]	Panayiotidis MI,Rancourt RC,Allen CB,et al.Hyperoxia-induced DNA damage causes decreased DNA methylation in human lung epithelial-like A549 cells.Antioxid Redox Signal,2004,6(1):129-136.
[19]	Turk PW,Laayoun A,Smith SS,et al.DNA adduct 8-hydroxyl-2'-deoxyguanosine (8-hydroxyguanine) affects function of human DNA methyltransferase.Carcinogenesis,1995,16(5):1253-1255.
[20]	Gaudet F,Hodgson JG,Eden A,et al.Induction of tumors in mice by genomic hypomethylation.Science,2003,300(5618):489-492.
[21]	Morgan WF.Non-targeted and delayed effects of exposure to ionizing radiation:Ⅱ.Radiation-induced genomic instability and bystander effects in vivo,clastogenic factors and transgenerational effects.Radiat Res,2003,159(5):581-596.
[22]	Lengauer C,Kinzler KW,Vogelstein B.Genetic instability in colorectal cancers.Nature,1997,386(6625):623-627.
[23]	Jaenisch R,Bird A.Epigenetic regulation of gene expression:how the genome integrates intrinsic and environmental signals.Nat Genet,2003,33(Suppl):245-254.
[24]	Chen RZ,Pettersson U,Beard C,et al.DNA hypomethylation leads to elevated mutation rates.Nature,1998,395(6697):89-93.
[25]	Sakata J,Inoue J,Ohi H,et al.Involvement of V (D) J recombinase in the generation of intragenic deletions in the Rit1/Bcl11b tumor suppressor gene in gamma-ray-induced thymic lymphomas and in normal thymus of the mouse.Carcinogenesis,2004,25(6):1069-1075.

[1]	张锦明 , 田嘉禾 , 刘伯里 . 影响PET放射性药物¹¹C甲基化的因素. 国际放射医学核医学杂志, 2006, 30(5): 271-274.
[2]	陈迪 , 金璀珍 . 辐射细胞遗传学分析的自动化. 国际放射医学核医学杂志, 1994, 18(6): 241-244.
[3]	官宜彬 , 朱壬葆 . 小鼠辐射性淋巴瘤与相关病毒. 国际放射医学核医学杂志, 1983, 7(2): 76-81.
[4]	宁静 , 于鹏 , 刘家金 , 党浩丹 , 徐白萱 . ¹⁸F-FDG PET/CT图像的影像组学分析在胶质瘤MGMT基因甲基化状态评估中的初步应用. 国际放射医学核医学杂志, 2020, 44(8): 486-492. doi: 10.3760/cma.j.cn121381-201903057-00064
[5]	卜桂兰 , 王献理 , 张景源 . 原爆的辐射遗传学影响的研究——关于DNA水平的试行调查. 国际放射医学核医学杂志, 1994, 18(5): 214-214.
[6]	张焕腾 , 孙毓筱 , 徐畅 . 泛素化修饰和SUMO化修饰在电离辐射诱导的DNA损伤修复中的作用机制. 国际放射医学核医学杂志, 2024, 48(2): 130-136. doi: 10.3760/cma.j.cn121381-202308031-00389
[7]	于文儒 , 赵文正 , 肖佩新 . 遗传性辐射敏感综合征. 国际放射医学核医学杂志, 1991, 15(1): 5-9.
[8]	朱寿彭 . 辐射诱发遗传毒理效应研究. 国际放射医学核医学杂志, 1992, 16(1): 4-7.
[9]	王宏 , 刘强 , 杜丽清 , 王彦 , 付岳 , 陈凤华 , 樊飞跃 . DNA修复基因hOGG1的寡核苷酸多态性与癌症遗传易感性的关系. 国际放射医学核医学杂志, 2012, 36(2): 101-104. doi: 10.3760/cma.j.issn.1673-4114.2012.02.011
[10]	许廷贵 , 穆传杰 . N-甲基甲酰胺增强辐射诱发人结肠癌细胞DNA双链断裂和微核形成. 国际放射医学核医学杂志, 1990, 14(6): 260-260.
[11]	李雨 , 罗成基 , 郑秀龙 . 电离辐射与AT的遗传学研究. 国际放射医学核医学杂志, 1997, 21(3): 130-133.

点击查看大图

计量

文章访问数: 1419
HTML全文浏览量: 167
PDF下载量: 3

电离辐射诱导的DNA甲基化模式改变及其在辐射致癌机制研究中的意义

石大伟^,
赵永成

通讯作者: 石大伟, davidstone340@yahoo.com;

300192 天津, 中国医学科学院中国协和医科大学放射医学研究所生物学研究室

收稿日期: 2006-02-08

关键词:

摘要: 越来越多的研究已经表明,表观遗传机制在癌症发生发展中扮演了非常重要的角色,但是对于辐射致癌的表观遗传机制的研究仅刚刚起步。本文介绍了表观遗传和一种重要的表观遗传标志——DNA甲基化的相关概念,并综述了近年来人们对电离辐射诱导的DNA甲基化模式改变的研究以及DNA甲基化模式改变在辐射致癌机制研究中的意义。