动脉粥样硬化斑块显像研究进展

张艳容

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动脉粥样硬化斑块显像研究进展

  • 中图分类号: R543.5;R817

The progress of research on atherosclerotic plaque imaging

  • CLC number: R543.5;R817

  • 摘要: 现有的一些用于动脉粥样硬化斑块诊断的检测方法如X线血管造影、血管内超声、光学相干体层扫描、B-型超声、电子束CT、核磁共振、拉曼光谱学检查和温度测量法等,在显示血管腔狭窄、管壁增厚、斑块体积以及斑块成分等方面各有其独特价值。但是,它们或因是创伤性检查、或因为检查本身的局限性(如只能显示钙化)、或不能早期发现以代谢紊乱为特征的病变,因而限制了它们在临床上的广泛应用。利用核素标记参与动脉粥样硬化的中间物质进行显像,可以精确、定量反映斑块成分和代谢情况,为无创伤性显示动脉粥样硬化斑块带来了希望,在疾病筛选、治疗决策、疗效观察以及随访研究上具有广阔的应用前景。
  • [1] Zaman AG, Helft G, Worthley SG, et al. The role of plaque rupture and thrombosis in coronary artery disease[J].Atherosclerosis, 2000, 149(2):251-266.
    [2] Prati F, Arbustini E, Labellarte A, et al. Correlation between high frequency intravascular ultrasound and histomorphology in human coronary arteries[J]. Heart, 2001, 85(5):567.
    [3] Gronholdt ML. B-mode ultrasound and spiral CT for the assessment of carotid atherosclerosis[J]. Neuroimag Clin N Am, 2002, 12(3):421-435.
    [4] Budoff MJ, Raggi P. Coronary artery disease progression assessed by electron-beam computed tomography[J]. Am J Cardiol, 2001, 88(2A):46E-50E.
    [5] Prigent FM, Steingart RM. Clinical value of electron-beam computed tomography in the diagnosis ang prognosis of coronary artery disease[J]. Curr Opin Cardiol, 1997, 12(6):561-565.
    [6] Schroeder S, Kopp AF, Ohnesorge B, et al. Virtual coronary angioscopy using multislice computed tomography[J]. Heart,2002, 87(3):205-209.
    [7] Shinnar M, Fallon JT, Wehrli S, et al. The diagnostic accuracy of ex vivo MR1 for human atherosclerotic plaque characterization[J]. Arterioscler Thromb Vasc Biol, 1999, 19(11):2756-2761.
    [8] Chan SK, Jaffer FA, Botnar RM, et al. Scan reproducibility of magnetic resonance imaging assessment of aortic atherosclerosis burden[J]. J Cardiovasc Magn Reson, 2001,3(4):331-338.
    [9] Yuan C, Kerwin WS, Ferguson MS, et al. Contrast-enhanced high resolution MRI for atherosclerotic carotid artery tissue characterization[J]. J Magn Reson Imaging, 2002,15(1):62-67.
    [10] Yabushita H, Bouma BE, Houser SL, et al. Characterization of human atherosclerosis by optical coherence tomography[J]. Circulation, 2002,106(13):1640-1645.
    [11] Tearney GJ, Yabushita H, Houser SL, et al. Quantification of macrophage content in atherosclerotic plaques by optical coherence tomography[J]. Circulation, 2003, 107(1):113.
    [12] Romer TJ, Brennan JF 3rd, Fitzmaurice M, et al.Histopathology of human coronary atherosclerosis by quantifying its chemical composition with Raman spectroscopy[J]. Circula-tion, 1998, 97(9):878-885.
    [13] van dc Poll SW, Romer TJ, Puppels GJ, et al. Imaging of atherosclerosis. Raman spectroscopy of atherosclerosis[J]. J Cardiovasc Risk, 2002, 9(5):255-261.
    [14] de Korte CL, Sierevogel MJ, Mastik F, et al. Identification of atherosclerotie plaque components with intravascular ultrasound elastography in vivo:a Yucatan pig study[J]. Circulation, 2002, 105(14):1627-1630.
    [15] Stefanadis C, Diamantopoulos L, Demellis J, et al. Heart production of atherosclerotic plaques and inflammation assessel by the acute phase proteins in acute coronary syndromes[J]. J Mol Cell Cardiol, 2000, 32(1):43-52.
    [16] Tsimikas S. Noninvasive imaging of oxidized low-density lipoprotein in atherosclerotic plaques with tagged oxidationspecific antibodies[J]. Am J Cardiol, 2002, 90(10c):22L.
    [17] Zhang YX, Cao W, Wu ZJ. Radioiodine labeled SP-4 as an imaging agent for atherosclerotic plaques[J]. Nucl Scien Tech, 2000, 11(4):234-237.
    [18] Dinkelborg LM, Duda SH, Hanke H, et al. Molecular imaging of atherosclerosis using a technetium-99m-labeled endothelin derivative[J]. J Nucl Med, 1998, 39:1819-1822.
    [19] Lederman RJ, Raylman RR, Fisher SJ, et al. Detection of atherosclerosis using a novel positron-sensitive probe and 18-fluorodeoxyglucose(FDG)[J]. Nucl Med Commun, 2001,22(7):747-753.
    [20] Rudd JH, Warburton EA, Fryer TD, et al. Imaging atherosclerotic plaque inflammation with[18F]-fluorodeoxyglucose positron emission tomography[J]. Circulation, 2002, 105(23):2708-2711.
    [21] Elmaleh DR, Narula J, Babich JW, et al. Rapid noninvasive detection of experimental atherosclerotic lesion with novel 99mTc-labeled diadenosine tetraphosphates[J]. Proc Natl Acad Sci USA, 1998, 95:691-695.
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  • 收稿日期:  2003-09-24

动脉粥样硬化斑块显像研究进展

  • 430022 武汉, 华中科技大学同济医学院附属协和医院核医学科

摘要: 现有的一些用于动脉粥样硬化斑块诊断的检测方法如X线血管造影、血管内超声、光学相干体层扫描、B-型超声、电子束CT、核磁共振、拉曼光谱学检查和温度测量法等,在显示血管腔狭窄、管壁增厚、斑块体积以及斑块成分等方面各有其独特价值。但是,它们或因是创伤性检查、或因为检查本身的局限性(如只能显示钙化)、或不能早期发现以代谢紊乱为特征的病变,因而限制了它们在临床上的广泛应用。利用核素标记参与动脉粥样硬化的中间物质进行显像,可以精确、定量反映斑块成分和代谢情况,为无创伤性显示动脉粥样硬化斑块带来了希望,在疾病筛选、治疗决策、疗效观察以及随访研究上具有广阔的应用前景。

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