<sup>18</sup>F-fallypride:一种多巴胺D2受体PET显像剂

杨敏

¹⁸F-fallypride:一种多巴胺D2受体PET显像剂

杨敏

文章导航 > 国际放射医学核医学杂志 > 2003, 27 > 6: (259-262)

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¹⁸F-fallypride:一种多巴胺D2受体PET显像剂

杨敏

江苏省原子医学研究所

作者简介: 杨敏(1972-),女,助理研究员,中国药科大学博士研究生,主要从事核药学的研究。;

中图分类号: R962

¹⁸F-fallypride: an excellent dopamine D2 receptor imaging agent for PET

YANG Min

Jiangsu Institute of Nuclear Medicine, State Key Laboratory of Nuclear Medicine, Wuxi 214063, China
CLC number: R962

摘要: ¹⁸F-fallypride是一种新的多巴胺D2受体PFT显像剂,它与多巴胺D2受体亲和力高(K_i=0.03nmol/L)、亲脂性适宜(logK_w=2.43),适于纹状体及纹状体外多巴胺D2/D3受体显像。对其合成、药理作用及体内过程、临床应用等进行了综述。
- 多巴胺D2受体 /
- ¹⁸F-fallypride /
- 正电子发射体层显像
Abstract: ¹⁸F-fallypride is a novel dopamine D2 receptor imaging agent for PET. With the high affinity to dopamine D2 receptor (K_i=0.03 nmol/L) and moderate lipophilicity (logK_w=2.43), it is suitable for visualizing both striatal and extrastriatal dopamine D2/D3 receptor binding in the brain. Its synthesis, pharmacology, distribution in vivo and clinic study are reviewed in this paper.
- dopamine D2 receptor /
- ¹⁸F-fallypride /
- positron emission tomography
本作品遵循Signature-Non-Commercial Use 4.0 International (CC BY-NC 4.0)协议

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