对乏氧和射线应答的嵌合性基因启动子的研究进展

郑爱青; 于金明

郑爱青 , 于金明

文章导航 > 国际放射医学核医学杂志 > 2004, 28 > 2: (74-77)

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对乏氧和射线应答的嵌合性基因启动子的研究进展

250117 济南, 山东省肿瘤医院基础研究中心
基金项目:
山东省重大攻关项目(031050102)
中图分类号: Q691;R730.55

Development of chimeric gene promoters responsive to hypoxia and ionizing radiation

Basic Research Center, Shan dong Tumor Hospital, Jinan 250117, China
CLC number: Q691;R730.55

摘要: 介绍两种应用射线和乏氧应答启动子调节的GDEPT(定向基因酶前体药物治疗)系统。用治疗性、条件性或肿瘤特异性启动子控制GDEPT是一种控制靶基因在肿瘤内表达的方法。通过选择性启动子,使基因靶向肿瘤内表达,提高特异性和靶向性,解决了肿瘤基因治疗中的主要限制。
- 放射治疗 /
- 基因治疗 /
- 肿瘤
Abstract: We describe two systems that make use of gene, directed enzyme prodrug therapy, regulated by radiation or hypoxic, responsive promoters. The use of treatment-, condition- or tumor-specific promoters to control gene-directed enzyme prodrug therapy is one such method for targeting gene expression to the tumor. The development of such strategies that achieve tumor targeted expression of genes via selective promoters will enable improved specificity and targeting thereby addressing one of the major limitations of cancer gene therapy.
- radiotherapy /
- gene therapy /
- tumor
本作品遵循Signature-Non-Commercial Use 4.0 International (CC BY-NC 4.0)协议

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