分化型甲状腺癌患者血清Tg和TgAb检测与结果分析应注意的问题
Critical problems in the measurement and clinical evaluation of serum thyroglobulin and thyroglobulin antibody in differentiated thyroid cancer
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摘要: Tg(甲状腺球蛋白)是非常重要的随访分化型甲状腺癌的血清肿瘤标志物。但是,保证血清Tg检测的精密度和可靠性仍是目前体外检验最为困难的问题之一,不论采用哪种检测方法,TgAb(甲状腺球蛋白抗体)的干扰都是影响血清Tg检测结果最为重要的因素。本文对分化型甲状腺癌患者血清Tg及TgAb检测与临床结果分析时应注意的若干问题进行了简要综述。Abstract: Tg (thyroglobulin) is an established serum tumour marker in the follow-up of differentiated thyroid cancer. However, serum Tg measurement remains one of the most difficult biochemical tests for a laboratory to maintain to a high level of precision and reliability. TgAb (Tg antibody) interference is the most serious specificity problem affecting serum Tg measurement, regardless of the assay. This review presented an overview of the critical problems that should he taken into account in the measurements and clinical evaluation of serum Tg and TgAb in differentiated thyroid cancer.
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Key words:
- differentiated thyroid cancer /
- thyroglobulin /
- thyroglobulin antibody
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