放射免疫导向治疗真菌感染灶的研究

蒋宁一; 熊玥

放射免疫导向治疗真菌感染灶的研究

蒋宁一 , 熊玥

文章导航 > 国际放射医学核医学杂志 > 2008, 32 > 3: (137-139)

引用本文:

Citation:

放射免疫导向治疗真菌感染灶的研究

蒋宁一,
熊玥

510120 广州, 中山大学附属第二医院核医学科

Research about the radioimmunotherapy of fungal infection

Department of Nuclear Medicine, Second Affiliated Hospital, Sun Yat-sen University, Guangzhou 510120, China

摘要: 由于广谱抗生素、皮质类同醇和免疫抑制剂的广泛应用,可能会导致机体免疫力低下,使致病真菌感染的机会增大,寻找更好的抗真菌疗法是医学研究方向之一。电离辐射可以快速有效的杀死微生物,也可以抗真菌。研究表明,通过特异性抗体标记的靶向放射免疫治疗方法将可能成为抗真菌的一种有效治疗途径。
- 放射免疫疗法 /
- 真菌病 /
- 抗体 /
- 真菌 /
- 铼
Abstract: The wide use of the broad-spectrum antibiotics,corticosteroids and immunosuppressant may lead to lower immunity which can increases the chance of fungi infection.Searching a better antifungal therapy is one of the direction of medical research.Ionizing radiation can quickly and effectively kill the microorganisms,and also can be the antifungal.The research suggests that the method of targeting radioimmunotherapy labeled specific antibody may become an effective antifungal treatment channels.
- Radioimmunotherapy /
- Mycoses /
- Antibodies /
- fungal /
- Bhenimn
本作品遵循Signature-Non-Commercial Use 4.0 International (CC BY-NC 4.0)协议

[1]	Beck-Sagué C, Jarvis WR. Secular trends in the epidemiology of nosocomial fungal infections in the United States, 1980-1990. National Nosocomial Infections Surveillance System[J]. J Infect Dis,1993, 167(5):1247-1251.
[2]	Wisplinghoff H, Seifert H, Tallent SM, et al. Nosocomial bloodstream infections in pediatric patients in United States hospitals:epidemiology, clinical features and susceptibilities[J]. Pediatr Infect Dis J, 2003, 22(8):686-691
[3]	吴安华,任南,文细毛,等.全国医院感染监控网1998-1999年监测资料分析[J].中华医院感染学杂志,2000,10(6):401-403.
[4]	Loeffler J, Stevens DA. Antifungal drug resistance[J]. Clin Infect Dis,2003, 36(Suppl 1):S31-S41.
[5]	Klein SA, Hermann S, Dietrich JW, et al. Transplantation related toxicity and acute intestinal graft-versus-host disease after conditioning regimens intensified with Rhenium 188-labeled anti-CD66 monoclonal antibodies[J]. Blood, 2002, 99(6):2270-2271.
[6]	Dadachova E, Bryan RA, Apostolidis C, et al. Interaction of radiolabeled antibodies with fungal cells and components of the immune system in vitro and during radioimmunotherapy for experimental fungal infection[J]. J Infect Dis, 2006, 193(10):1427-1436.
[7]	Dadachova E, Howell RW, Bryan RA, et al. Susceptibility of the human pathogenic fungi Cryptococcus neoformans and Histoplasma capsulatum to gamma-radiation versus radioirmnunotherapy with alpha-and beta-emitting radioisotopes[J]. J Nucl Med, 2004, 45(2):313-320.
[8]	杨斌,何杨,张玮,等. ⁹⁹Tc ^m-抗人粒细胞单克隆抗体对兔炎症的放射免疫显像[J].中华核医学杂志,2002,22(4):228-230.
[9]	Shokeen M, Fettig NM, Rossin R. Synthesis, in vitro and in vivo evaluation of radiolabeled nanoparticles[J]. Q J Nucl Med Mol Imaging, 2008, 52(3):267-277.
[10]	Rosas AL, Nosanchuk JD, Casadevall A. Passive Immunization with melanin-binding monoclonal antibodies prolongs survival of mice with lethal Cryptococcus neoformans Infection[J]. Infect Immun, 2001, 69(5):3410-3412.
[11]	Dadachova E, Patel MC, Toussi S, et al. Targeted killing of virally infected cells by radiolabeled antibodies to viral proteins[J]. PloS Med, 2006, 3(11):e427.
[12]	Rodrigues ML, Travassos LR, Miranda KR, et al. Human antibodies against a purified glucosylceramide from Cryptococcus neoformans inhibit cell budding and fungal growth[J]. Infect Immun, 2000, 68(12):7049-7060.
[13]	Casadevall A, Cleare W, Feldmesser M, et al. Characterization of a murine monoclonal antibody to Cryptococcus neoformans polysaccharide that is a candidate for human therapeutic studies[J]. Antimicrob Agents Chemother, 1998, 42(6):1437-1446.
[14]	Dadachova E, Casadenall A. Antibodies as delivery vehicles for radioirmnunotherapy of infectious diseases[J]. Expert Opin Drug Deliv, 2005, 2(6):1075-1084.
[15]	Dadachova E, Nakouzi A, Bryan RA, et al. Ionizing radiation delivered by specific antibody is therapeutic against a fungal infection[J]. Proc Natl Acad Sci USA, 2003, 100(19):10942-10947.

[1]	赵舒雅 , 李航 , 樊赛军 . ASTL抗体中和ASTL对人宫颈癌ME-180细胞放射敏感性的影响. 国际放射医学核医学杂志, 2021, 45(12): 773-782. doi: 10.3760/cma.j.cn121381-202009033-00125
[2]	张建媛 , 缪蔚冰 . 电化学发光法与放射性受体分析法检测促甲状腺激素受体抗体的对比研究. 国际放射医学核医学杂志, 2012, 36(1): 20-23. doi: 10.3760/cma.j.issn.1673-4114.2012.01.005
[3]	魏莉 , 罗荣城 . 放射性核素标记抗CD20单克隆抗体治疗B细胞淋巴瘤的研究进展. 国际放射医学核医学杂志, 2006, 30(3): 153-157.
[4]	吴涛 , 刘长征 . 胶体铼及其应用. 国际放射医学核医学杂志, 2004, 28(4): 160-162.
[5]	于晓明 , 樊飞跃 . 肿瘤放射免疫疗法研究进展. 国际放射医学核医学杂志, 2006, 30(2): 80-83.
[6]	冯彦林 , 谭家驹 , 梁生 , 孙静 , 吴校连 , 司建华 , 夏姣云 , 温广华 . [¹⁸⁸Re(CO)₃(H₂O)₃]⁺间接标记免疫磁性纳米微粒的实验研究. 国际放射医学核医学杂志, 2007, 31(4): 211-214.
[7]	姚红霞 , 张金山 . 微波消融和¹³¹I-肿瘤细胞核人鼠嵌合单克隆抗体联合治疗肺癌. 国际放射医学核医学杂志, 2012, 36(5): 264-268, 306. doi: 10.3760/cma.j.issn.1673-4114.2012.05.002
[8]	郭艾楠 , 魏玲格 , 傅鹏 . ¹³¹I-肿瘤细胞核人鼠嵌合单克隆抗体治疗实体瘤的研究进展. 国际放射医学核医学杂志, 2013, 37(2): 120-123. doi: 10.3760/cma.j.issn.1673-4114.2013.02.015
[9]	冯彦林 , 谭家驹 , 梁生 , 孙静 , 温广华 , 吴校连 , 夏姣云 . 抗人肝癌¹⁸⁸Re-免疫磁性纳米微粒的生物学分布和肿瘤细胞抑制实验. 国际放射医学核医学杂志, 2007, 31(6): 321-324,328.
[10]	冯春玲 . 放射免疫治疗中载体的研究进展. 国际放射医学核医学杂志, 2007, 31(2): 77-79.