细胞因子在急性辐射损伤治疗中的作用

苗莉; 缪竞诚

细胞因子在急性辐射损伤治疗中的作用

苗莉 , 缪竞诚

文章导航 > 国际放射医学核医学杂志 > 2006, 30 > 3: (173-176)

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细胞因子在急性辐射损伤治疗中的作用

苗莉,
缪竞诚

215123 苏州, 苏州大学医学院细胞分子生物学教研室
基金项目:
国防科工委基础科研计划(K0102061501)
中图分类号: R818.05

Effects of cytokine on acute radiation injury

Department of Cell and Molecular Biology, Soochow University, Suzhou 215123, China
CLC number: R818.05

摘要: 急性辐射损伤以及肿瘤患者在放疗或化疗后,均可发生程度不等的骨髓功能抑制。一些细胞因子通过刺激不同分化时期、不同类型的靶细胞影响其增殖和分化,从而对骨髓造血细胞起辐射防护和促进骨髓造血恢复的作用。随着基因工程的发展,人们可以获得越来越多的高纯度重组造血因子,这些因子在急性辐射损伤的实验研究和临床救治中发挥了极其重要的作用。同时,细胞因子治疗也存在一些问题,有待进一步研究和解决。
- 造血细胞生长因子 /
- 辐射损伤 /
- 造血干细胞动员
Abstract: Acute radiation injury as well as radiotherapy and chemotherapy of tumor can lead to different extents of bone marrow aplasia. Some cytokines play an important role in cell proliferation and differentiation by stimulating types of target cells which are at different stages, so that they can protect hematopoietic cells from radiation and improve hematopoiesis. With the development of gene engineering technology, more and more high purity recombinant hematopoietic factors can be caquired, which is vital in the experimental research and clinical therapy of acute radiation injury. Meanwhile, further researches are required to solve the problems in cytokine-based therapy.
- Hematopoietic cell growth factors /
- Radiation injury /
- Hematopoietic stem cell mobilization
本作品遵循Signature-Non-Commercial Use 4.0 International (CC BY-NC 4.0)协议

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细胞因子在急性辐射损伤治疗中的作用

苗莉
缪竞诚

215123 苏州, 苏州大学医学院细胞分子生物学教研室

收稿日期: 2006-02-25

基金项目: 国防科工委基础科研计划(K0102061501)

关键词:

摘要: 急性辐射损伤以及肿瘤患者在放疗或化疗后,均可发生程度不等的骨髓功能抑制。一些细胞因子通过刺激不同分化时期、不同类型的靶细胞影响其增殖和分化,从而对骨髓造血细胞起辐射防护和促进骨髓造血恢复的作用。随着基因工程的发展,人们可以获得越来越多的高纯度重组造血因子,这些因子在急性辐射损伤的实验研究和临床救治中发挥了极其重要的作用。同时,细胞因子治疗也存在一些问题,有待进一步研究和解决。