放射性肺纤维化分子机制的研究进展

李杨

放射性肺纤维化分子机制的研究进展

李杨

文章导航 > 国际放射医学核医学杂志 > 2003, 27 > 2: (75-77)

引用本文:

Citation:

放射性肺纤维化分子机制的研究进展

李杨

100850 北京, 军事医学科学院放射医学研究所实验病理研究室

作者简介: 李杨(1973-),女,博士研究生,主要从事放射病理学研究。;

基金项目:
国家自然科学基金项目(30170292)
中图分类号: R818.02

Studies on the molecular pathogenesis of radiation pulmonary fibrosis

LI Yang

Institute of Radiation Medicine, Academy Military Medical Science, Beijing 100850, China
CLC number: R818.02

摘要: 放射性肺纤维化是临床放射治疗的常见并发症,也可见于战时核辐射、平时核事故。关于其发病机制的研究已深入到分子水平,多种细胞因子、粘附分子、血管活性多肽参与了放射性肺纤维化的发生发展,某些基因与其发生具有相关性。分子机制的研究也给防治措施提供了新思路和新途径。
- 放射性肺纤维化 /
- 细胞因子 /
- 粘附分子 /
- 血管活性多肽
Abstract: Radiation pulmonary fibrosis(RPF) is a frequent side effect of thoracic radiotherapy for breast neoplasm and total body irradiation before bone marrow transplantation. Studies on its pathogenesis have arrived at molecular level. Many cytokines, adhesion molecules and vasoactive substances all play important role in the course of RPF. Moreover, there exists genetic loci that has relation with RPF. Furthermore, studies on the molecular pathogenesis of RPF have pro? vided new ideas and new measures for the precaution and therapy of RPF.
- radiation pulmonary fibrosis /
- cytokine /
- adhesion molecules /
- vasoactive polypeptide
本作品遵循Signature-Non-Commercial Use 4.0 International (CC BY-NC 4.0)协议

[1]	Bitterman PB, Adlberg S, Crystal RG. Mechanisms of pulmonary fibrosis[J]. J Clin Invest, 1983, 72:1801-1806.
[2]	Philip R, Carl JJ, Jacqueline P, et al. A perpetual cascade of cytokines postirradiation leads to pulmonary fibrosis[J]. Int J Radiat Oncol Biol Phys, 1995, 33(1):99-109.
[3]	Michele M, Jean-louse L, Sylvie D, et al. TGF-β₁ and radiation fibrosis:a master switch and a specific therapeutic target?[J]. Int J Radiat Oncol Biol Phys, 2000, 47(2):277-290.
[4]	El-Gamel A, Award PS, Yonan NA, et al. Transforming growth factor-beta (TGF-beta1) genotype and lung allograft fibrosis[J]. J Heart Lung Transplant, 1999, 18(6):517-523.
[5]	Roberts AB, Piek E, Bottinger EP, et al. Is Smad3 a major player in signal transduction pathways leading to fibrogene-sis?[J]. Chest, 2001, 120(1 suppl):43s-47s.
[6]	Verrecchia F, Mauviel A. Transforming growth factor-β signaling through the smad pathway:role in extracellular matrix gene expression and regulation[J]. J Invest Derma,2002, 118(2):211-215.
[7]	Ghosh AK, Yuan WH, Mori Y, et al. Antagonistic regulation of type I collagen gene expression by interferon-γ and transforming growth factor-β[J]. J Biol Chem, 2001, 276(14):11041-11048.
[8]	Zhang Y, Feng XH, Rik D. Smad3 and Smad4 cooperate with c-jun/c-fos to mediate TGF-β-induced transcription[J]. Nature, 1998, 394(27):909-913.
[9]	Michael B, Datto W, Yong Y, et al. Functional analysis of the transforming growth factor responsive elements in the WAF1/Cip1/P21 promoter[J]. J Biol Chem, 1995, 270(48):28623-28628.
[10]	Johnston CJ, Williams JP, Okunieff P. Radiation-induced pulmonary fibrosis:examination of chemokine and chemokine receptor families[J]. Radiat Res, 2002, 157(3):256-265.
[11]	Hallahan DE, Geng L, Shyr Y. Effects of intercellular adhesion molecule 1(ICAM-1) null mutation on radiation-induced pulmonary fibrosis and respiratory insufficiency in mice[J]. J Natl Cancer Inst, 2002, 94(10):733-741.
[12]	Song LW, Wang DW, Cui XM, et al. Kinetic alterations of angiotensin-Ⅱ and nitric oxide in radiation pulmonary fibro-sis[J]. J Environ Pathol Toxicol Oncol, 1998,17(2):141-150.
[13]	Molteni A, Moulder JE, Cohen EF, et al. Control of radia-tion-induced pneumopathy and lung fibrosis by angiotensin-converting enzyme inhibitors and an angiotensin Ⅱ type 1 receptor blocker[J]. Int J Radiat Biol, 2000, 76(4):523-532.
[14]	Haston CK, Zhou X, Gumbiner-Russo L. Universal and radiation-specific loci influence murine susceptibility to radiation-induced pulmonary fibrosis[J]. Cacer Res, 2002, 62(13):3782-3788.
[15]	Mori M, Kida H, Morishita H, et al. Microsatellite instability in transforming growth factor-beta 1 type I receptor gene in alveolar lining epithelial cells of idiopathic pulmonary fibro-sis[J]. Am J Respir Cell Mol Biol, 2001, 24(4):398-404.
[16]	Haase M, Geyer P, Appold S, et al. Down-regulation of SP1 DNA binding activity in the process of radiation-induced pulmonary fibrosis[J]. Int J Radiat Biol, 2000, 76(4):487-492.

[1]	曹京旭 , 张旭志 . 细胞因子与放射性肺损伤. 国际放射医学核医学杂志, 2001, 25(4): 181-185.
[2]	王玉祥 . 电离辐射对血管内皮细胞与白细胞粘附的影响. 国际放射医学核医学杂志, 2001, 25(3): 130-134.
[3]	韩光 , 周福祥 , 周云峰 . 放射性肺损伤的研究. 国际放射医学核医学杂志, 2005, 29(6): 282-286.
[4]	李娜 , 李科君 , 王彦 , 徐畅 , 纪凯华 , 何宁宁 , 王芹 , 柳杨 , 刘强 , 杜利清 . SD大鼠放射性肺纤维化模型的建立及评价. 国际放射医学核医学杂志, 2020, 44(1): 52-58. doi: 10.3760/cma.j.issn.1673-4114.2020.01.011
[5]	梁鑫鑫 , 敖兴坤 , 周圣辉 , 顾永清 . TGF-β1在放射性肺损伤中的促纤维化作用及其机制. 国际放射医学核医学杂志, 2022, 46(9): 571-575. doi: 10.3760/cma.j.cn121381-202110030-00218
[6]	闫风琴 , 鞠桂芝 . 辐射及细胞因子对p21基因表达的调控作用. 国际放射医学核医学杂志, 2004, 28(6): 278-280.
[7]	闵锐 . 辐射损伤防护药及细胞因子治疗研究动态. 国际放射医学核医学杂志, 2004, 28(4): 173-178.
[8]	邢爽 , 李明 , 黄海潇 , 罗庆良 . 急性辐射损伤的细胞因子联合治疗研究进展. 国际放射医学核医学杂志, 2008, 32(1): 47-50.
[9]	刘强 . 放射性脑损伤研究现状. 国际放射医学核医学杂志, 2004, 28(4): 178-181.
[10]	王军英 , 涂彧 , 周菊英 , 徐晓婷 , 王利利 . 前列腺素E₁注射液对急性放射性肺损伤的保护作用. 国际放射医学核医学杂志, 2007, 31(2): 115-117.