正电子显像剂<sup>11</sup>C-匹兹堡化合物B的化学合成及其临床应用

陈贵兵; 吴华; 彭添兴

正电子显像剂¹¹C-匹兹堡化合物B的化学合成及其临床应用

陈贵兵 , 吴华 , 彭添兴

文章导航 > 国际放射医学核医学杂志 > 2008, 32 > 3: (158-161)

引用本文:

Citation:

正电子显像剂¹¹C-匹兹堡化合物B的化学合成及其临床应用

361003 福建, 福建医科大学附属厦门第一医院核医学科、闽南PET中心

Chemical synthesis and clinical application of a new positron imaging agent ¹¹C-Pittsburgh compound-B

Department of Nuclear Medicine, Minnan PET Center, Xiamen First Hospital, Fujian Medical University, Xiamen 361003, China

摘要: 阿尔茨海默病(AD)是一种严重影响老年人生活质量的常见疾病。¹¹C-匹兹堡化合物B (¹¹C-PIB)作为新型B-淀粉样蛋白(Aβ)正电子显像剂,能够特异性地检出AD的特征性病理学改变,为AD的早期诊断、早期治疗乃至疗效评价提供了潜在的可能性。
- ¹¹C-匹兹堡化合物B /
- 阿尔茨海默病 /
- 体层摄影术,发射型计算机
Abstract: Alzheimer disease(AD)seriously influenced the quality of life in elderly.As a new positron imaging agent binding with B-amyloid,¹¹C-Pittsburgh compound-B can specifically detect characteristic pathological changes of AD.It provides the potential possibility of early diagnosis and treatment,effect evaluafion in AD.
- ¹¹C-Pittsburgh compound-B /
- Alzheimer disease /
- Tomography,emission-computed
本作品遵循Signature-Non-Commercial Use 4.0 International (CC BY-NC 4.0)协议

[1]	Mathis CA, Holt DP, Wang Y, et al. ¹¹C-labelled thioflavin-T analogues for amyloid plaques imaging in Alzheimer's disease[J]. J Label Compd Radiopharm, 2001, 44(1):26-28.
[2]	Mathis CA, Wang Y, Holt DP, et al. Synthesis and evaluation of ¹¹C-labelled 6-substituted 2-arylbenzothiazoles as amyloid imaging agents[J]. J Med Chem, 2003, 46(13):2740-2754.
[3]	Wilson AA, Garcia A, Chestakova A, et al. A rapid one-step radiosynthesis of the β-amyloid imaging radiotracer[¹¹C]6-OH-BTA-1[J]. J Label Compd Radiopharm, 2004, 47:679-682.
[4]	Toyama H, Ye D, Ichise M, et al. PET imaging of brain with the β-amyloid probe,[¹¹C]6-OH-BTA-1, in a transgenic mouse of Alzheimer's disease[J]. Eur J Nucl Med Mol Imaging, 2005, 32(5):593-600.
[5]	Klunk WE, Lopresti B J, Ikonomovic MD, et al. Binging of the positron emission tomography tracer Pittsburgh Compound-B reflects the amount of amyloid-beta in Alzheimer's disease brain but not in transgenic mouse brain[J]. J Neurosci, 2005, 25(46):10598-10606.
[6]	Klunk WE, Engler H, Nordberg A, et al. Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B[J]. Ann Neurol, 2004, 55(3):306-319.
[7]	Kemppainen NM, Aalto S, Wilson IA, et al. Voxel-based analysis of PET amyloid ligand[nC]PIB uptake in Alzheimer disease[J]. Neurology, 2006, 67(9):1575-1580.
[8]	Mintun MA, Larossa GN, Sheline YI, et al.[¹¹C]PIB in a nondemented population:potential antecedent marker of Alzheimer disease[J]. Neurology, 2006, 67(3):446-452.
[9]	Kemppainen NM, Aalto S, Wilson IA, et al. PET amyloid ligand[¹¹C]PIB uptake is increased in mild cognitive impairment[J]. Neurology, 2007, 68(19):1603-1606.
[10]	Price JC, Klunk WE, Lopresti BJ, et al. Kinetic modeling of amyloid binding in humans using PET imaging and Pittsburgh Compound-B[J]. J Cereb Blood Flow Metab, 2005, 25(11):1528-1547.
[11]	Ziolko SK, Weissfeld LA, Klunk WE. Evaluation of voxel-based methods for the statistical analysis of PIB PET amyloid imaging studies in Alzheimer's disease[J]. Neuroimage, 2006, 33(1):94-102.
[12]	Edison P, Archer HA, Hinz R,et al. Amyloid, hypometabolism, and cognition in Alzheimer disease:an[¹¹C]PIB and[^¹⁸F]FDG PET study[J]. Neurology, 2007, 68(7):501-508.
[13]	Scheinin NM, Tolvanen TK, Wilson IA, et al. Biodistribution and radiation dosimetry of the amyloid imaging agent ¹¹C-PIB in humans[J]. J Nucl Med, 2007, 48(1):128-133.

[1]	武晓丹 , 战莹 , 郭佳 , 陈宇峰 , 郝珊瑚 , 张国旭 , 王治国 . 脑脊液生物标志物与¹¹C-PIB PET/CT显像对阿尔茨海默病的诊断准确率及相关性研究. 国际放射医学核医学杂志, 2021, 45(1): 3-9. doi: 10.3760/cma.j.cn121381-202004019-00003
[2]	郭喆 , 张锦明 . 阿尔茨海默病的放射性分子显像探针研究进展. 国际放射医学核医学杂志, 2006, 30(4): 199-202.
[3]	蔡汉成 , 尹端沚 , 张岚 , 李谷才 , 郑明强 , 汪勇先 . 早期诊断阿尔茨海默病的PET分子探针. 国际放射医学核医学杂志, 2006, 30(4): 202-205.
[4]	张冰 , 徐俊 , 徐运 , 朱斌 . fMRI在阿尔茨海默病、额颞叶痴呆及路易体痴呆中的研究进展. 国际放射医学核医学杂志, 2010, 34(5): 303-307. doi: 10.3760/cma.j.issn.1673-4114.2010.05.015
[5]	王颖 , 蔡莉 , 李彦生 , 高硕 . ¹¹C-PIB PET在不同时期阿尔茨海默病中的研究进展. 国际放射医学核医学杂志, 2013, 37(6): 378-380,384. doi: 10.3760/cma.j.issn.1673-4114.2013.06.013
[6]	王瑞民 . 阿尔茨海默病等痴呆疾病的脑功能影像学研究. 国际放射医学核医学杂志, 2001, 25(5): 209-212.
[7]	宗佳滨 , 兰晓莉 , 张永学 . 阿尔茨海默病分子影像探针的研究进展. 国际放射医学核医学杂志, 2022, 46(1): 35-41. doi: 10.3760/cma.j.cn121381-202101045-00129
[8]	李祖贵 . 轻度认知障碍的功能性神经影像学研究进展. 国际放射医学核医学杂志, 2006, 30(2): 76-79.
[9]	暴丽洁 , 赵子龙 , 苏宁 , 周茂荣 . MRI和PET显像在阿尔茨海默病早期诊断中的应用. 国际放射医学核医学杂志, 2023, 47(4): 249-253. doi: 10.3760/cma.j.cn121381-202211009-00288
[10]	王新艳 , 管一晖 . 阿尔茨海默病的影像学诊断进展. 国际放射医学核医学杂志, 2013, 37(1): 52-59. doi: 10.3760/cma.j.issn.1673-4114.2013.01.014