辐射诱导旁效应研究进展

秦阳华; 韩玲

辐射诱导旁效应研究进展

秦阳华 , 韩玲

文章导航 > 国际放射医学核医学杂志 > 2004, 28 > 5: (234-236)

引用本文:

Citation:

辐射诱导旁效应研究进展

秦阳华,
韩玲

200433 上海, 第二军医大学海医系放射医学教研室
中图分类号: R730.231.2

Progress of radiation-induced bystander effect

Department of Radiation Medicine, Navy medicine Faculty, the Second Military Medical University, Shanghai 200433, China
CLC number: R730.231.2

摘要: 随着人们对低剂量辐射后发生的间接和延迟效应(如突变、基因不稳定性)的重视,以及新的高效工具(如单细胞微束和先进的培养系统)的应用,过去的十几年对辐射诱导旁效应的产生机制有了许多新的认识和发现。辐射诱导旁效应是受基因调控,由细胞间信号传递途径中介产生的。
- 电离辐射 /
- 旁效应 /
- 细胞间活性氧 /
- 间隙连接 /
- 一氧化氮
Abstract: With the increased awareness of the contribution of indirect and delayed effects (such as mutation, genomic instability) to cellular outcomes after low-dose exposures, and the availability of tools (such as the microbeam and advanced cell culture systems), many new discoveries about radiation-induced bystander effect has been achieved in the past decade. Evidence accumulated has indicated that radiation-induced bystander effect is regulated by special genes, and mediated by intercellual signal transmission pathway.
- ionizing radiation /
- bystander response /
- reactive oxygen species /
- gap-junction intercellular communication /
- nitric oxide
本作品遵循Signature-Non-Commercial Use 4.0 International (CC BY-NC 4.0)协议

[1]	Nagasawa H,Little JB.Induction of sister-chromatid exchanges by extremely low doses of alpha particles[J].Cancer Res,1992,52(22):6394-6396.
[2]	Azzam EI,de Toledo S M,Little JB,et al.Oxidative metabolism,gap junctions and the ionizing radiation-induced bystander effect[J].Oncogene,2003,22(45):7050-7057.
[3]	Matsumoto H,Hayashi S,Hatashita M,et al.Induction of radioresistance by a nitric oxide-mediated bystander effect[J].Radiat Res,2001,155(3):387-396.
[4]	Shao C,Furusawa Y,Aoki M,et al.Nitric oxide-mediated bystander effect induced by heavy-ions in human salivary gland tumour cells[J].Int J Radiat Biol,2002,78(9):837-844.
[5]	Wang Z,Cook T,Alber S,et al.Adenoviral gene transfer of the human inducible nitric oxide synthase gene enhances the radiation response of human colorectal cancer associated with alterations in tumor vascularity[J].Cancer Res,2004,64(4):1386-1395.
[6]	Narayanan PK,Goodwin E H,Lehnert BE.Alpha particles initiate biological production of superoxide anions and hydrogen peroxide in human cells[J].Cancer Res,1997,57(18):3963-3971.
[7]	Azzam EI,De Toledo S M,Spitz DR,et al.Oxidative metabolism modulates signal transduction and micronucleus formation in bystander cells from alpha-particle-irradiated normal human fibroblast cultures[J].Cancer Res,2002,62(19):5436-5442.
[8]	Babior BM.NADPH oxidase[J].Curr Opin Immunol,2004,16(1):42-47.
[9]	Azzam EI,de Toledo S M,Little JB.Direct evidence for the participation of gap junction-mediated intercellular communication in the transmission of damage signals from alpha-particle irradiated to nonirradiated cells[J].Proc Natl Acad Sci U S A,2001,98(2):473-478.
[10]	Zhou H N,Randers-Pehrson G,Waldren CA,et al.Induction of a bystander mutagenic effect of alphaparticles in mammalian cells[J].Proc Natl Acad Sci U S A,2000,97:2099-2104.
[11]	Zhou H N,Suzuki M,Randers-Pehrson G.Radiation risk to low flu-ences of alpha particles may be greater than we thought[J].Proc Natl Acad Sci USA,2001,98(25):14410-14415.
[12]	Azzam EI,de Toledo S M,Little JB.Expression of connexin43 is highly sensitive to ionizing radiation and other environmental stresses[J].Cancer Res,2003,63(21):7128-7135.
[13]	Lampe PD,Lau AF.Regulation of gap junctions by phosphorylation of connexins[J].Arch Biochem Biophys.2000,384(2):205-215.
[14]	Echetebu CO,Ali M,Izban MG.Localization of regulatory protein binding sites in the proximal region of human myometrial connexin 43 gene[J].Mol Hum Reprod.1999,5(8):757-766.

[1]	龚守良 . 一氧化氮与电离辐射. 国际放射医学核医学杂志, 2000, 24(4): 170-173.
[2]	陆颖 . 辐射诱发的旁效应研究. 国际放射医学核医学杂志, 2001, 25(5): 225-228.
[3]	周建华 , 苏燎原 . 免疫细胞双信号转导与电离辐射效应. 国际放射医学核医学杂志, 1999, 23(5): 223-226.
[4]	李海军 , 游冬青 , 闵锐 . 细胞粘附分子的电离辐射效应研究进展. 国际放射医学核医学杂志, 2004, 28(6): 270-274.
[5]	熊杰 , 韩玲 . 微束在辐射诱导的旁效应研究中的应用. 国际放射医学核医学杂志, 2002, 26(6): 281-284.
[6]	孙志增 , 周平坤 . 低剂量电离辐射效应. 国际放射医学核医学杂志, 2004, 28(2): 82-85.
[7]	肖瑶 , 韩玲 . 电离辐射诱导旁效应的研究现状. 国际放射医学核医学杂志, 2007, 31(5): 303-306.
[8]	陈凤 , 涂彧 . 电离辐射诱导旁效应的研究现状. 国际放射医学核医学杂志, 2009, 33(6): 364-367. doi: 10.3760/cma.j.issn.1673-4114.2009.06.015
[9]	杨英 , 龚守良 , 李修义 . T细胞共刺激反应与电离辐射. 国际放射医学核医学杂志, 1998, 22(5): 227-231.
[10]	龚守良 , 刘树铮 . 生精细胞凋亡与电离辐射. 国际放射医学核医学杂志, 1999, 23(5): 227-230.
[11]	丁为民 . 电离辐射与细胞动力学. 国际放射医学核医学杂志, 2000, 24(3): 132-135.