细胞粘附分子的电离辐射效应研究进展

李海军; 游冬青; 闵锐

细胞粘附分子的电离辐射效应研究进展

李海军 , 游冬青 , 闵锐

文章导航 > 国际放射医学核医学杂志 > 2004, 28 > 6: (270-274)

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细胞粘附分子的电离辐射效应研究进展

200433 上海, 第二军医大学海医系放射医学教研室
基金项目:
国家自然科学基金资助项目(30370444)
中图分类号: R811.5

The recent advance in radiation effects of cell adhesion molecules

Department of Radiation Medicine, Naval Medicine Faculty, Second Military Medical University, Shanghai 200433, China
CLC number: R811.5

摘要: 细胞粘附分子是调节细胞间及细胞与细胞外基质相互作用的一类膜型或跨膜糖蛋白,其作用涉及细胞的粘附、迁移、分化和信号转导。正常组织或肿瘤组织受电离辐射后会导致细胞粘附分子表达的改变。照射方式不同,受照组织不同,粘附分子的表达也不同,有些粘附分子的表达与受照剂量存在良好的量效关系。受照后,粘附分子的改变具有作为一种新的辐射生物剂量仪的潜能。
- 细胞粘附分子 /
- 电离辐射 /
- 基质金属蛋白酶 /
- 生物剂量仪
Abstract: Cell adhesion molecules(CAMs) are a group of membrane or transmembrane glycoproteins which modulate the cell-cell and cell-extracellular matrix interaction. The role of CAMs is involved in cell adhesion, migration, differentiation and signal transduction. Ionizing radiation can induce the changes of the CAMs in normal tissue or tumor tissue, depending on irradiation dose and postirradiation time. A good dose-effect pattern was found between expression of CAMs and exposure dose. It means that change of CAMs induced by radiation has a potential of biodosimetry of radiation.
- cell adhesion molecules /
- irradiation /
- matrix metalloproteinases /
- biodosimetry
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细胞粘附分子的电离辐射效应研究进展

200433 上海, 第二军医大学海医系放射医学教研室

收稿日期: 2004-06-13

基金项目: 国家自然科学基金资助项目(30370444)

关键词:

摘要: 细胞粘附分子是调节细胞间及细胞与细胞外基质相互作用的一类膜型或跨膜糖蛋白,其作用涉及细胞的粘附、迁移、分化和信号转导。正常组织或肿瘤组织受电离辐射后会导致细胞粘附分子表达的改变。照射方式不同,受照组织不同,粘附分子的表达也不同,有些粘附分子的表达与受照剂量存在良好的量效关系。受照后,粘附分子的改变具有作为一种新的辐射生物剂量仪的潜能。