Bexxar治疗非霍奇金淋巴瘤的研究现状

陈立波 朱瑞森

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Bexxar治疗非霍奇金淋巴瘤的研究现状

  • 中图分类号: R817.5

Current status of Bexxar for treatment of non-Hodgkin's lymphoma

  • CLC number: R817.5

  • 摘要: B细胞靶向特异性单克隆抗体的出现为惰性淋巴瘤的治疗提供了新的策略。由于淋巴瘤对辐射较为敏感,在过去的10年中,应用131I标记抗-CD20单克隆抗体(商品名:Bexxar)对化疗无效的非霍奇金淋巴瘤(NHL)患者进行放射免疫治疗取得了长足的发展。
  • [1] Vose JM, Wahl RL, Saleh M, et al. Muhicenter phase Ⅱ study of iodine-131 tositumomab for chemotherapy-relapsed/refractory lowgrade and transformed low-grade B-cell non-Hodgkin's lymphomas[J]. J Clin Oncol, 2000, 18(6):1316-1323.
    [2] Kaminski MS, Zelenetz AD, Press OW, et al. Pivotal study of iodine-131 tositumomah for chemotherapy-refractory low-grade or transformed low-grade B-cell non-Hodgkin's lymphomas[J]. J Clin Onool, 2001, 19(19):3918-3928.
    [3] Kaminski MS, Zelenetz AD, Leonard J, et al. Bexxar radioimmunotherapy produces a substantial number of durable complete responses in patients with multiply relapsed or refractory low grade or transformed low grade non-Hodgkin's lymphoma[J]. Blood, 2002,100(11):356a.
    [4] Gregory SA, Zelenetz A, Knox S, et al. BexxarTM is an effective and well tolerated therapy in elderly patients with non-Hodgkin lymphoma (NHL)[J]. Proc Am Soc Clin Oncol, 2001, 20(7):285a.
    [5] Rohatiner A, Kaminski M, Leonard J, et al. BexxarTM radioimmunotherapy is efficacious in non Hodgkin's lymphoma (NHL)patients with poor prognostic features[J]. Proc Am Soc Clin Oncol,2001, 20(7):286a.
    [6] Kaminski MS, Tuck M, Regan D, et al. High response rates and durable remissions in patients with previously untreated, advancedstage, follicular lymphoma treated with tositumomab and iodine- 131tositumomab (Bexxar(R))[J]. Blood,2002,100(11):356.
    [7] Leonard JP, Coleman M, Kostakoglu L, et al. Triple modality therapy for follicular low-grade lymphoma:initial treatment with fludarabine followed by BexxarTM (tositumomab and iodine-131 tositumomab)[J].Blood, 2001, 98(11):844a
    [8] Kaminski MS, Estes J, Zasadny KR, et al. Radioimmunotherapy with iodine- 131 tositumomab for relapsed or refractory B-cell non-Hodgkin lymphoma:updated results and long-term follow-up of the universityof Michigan experience[J]. Blood, 2000, 96(4):1259-1266.
    [9] Leonard JP, Frenette G, Dillman RO, et al. Interim safety and efficacy results of BexxarTM in a large multicenter expanded access study[J].Blood, 2001, 98(11):133a.
    [10] Kaminski MS. Tolerance of treatment subsequent to frontline BexxarTM (tositumomab and Ⅰ-131 tositumomab) in patients (pts) with follicular lymphoma[J]. Blood, 2001, 98(11):603a.
    [11] Schenkein DP, Leonard J, Harwood S, et al. Interim safety results of BexxarTM in a large multicenter expanded access study[J]. Proc Am Soc Clin Oncol, 2001, 20(7):285a.
    [12] Gregory SA, Coleman M, Dillman RO, et al. BexxarTMis a well-tolerated therapy in elderly patients with low-grade or transformed low-grade non-Hodgkin's lymphoma (NHL)[J]. Blood, 2001, 98(11):605a.
    [13] Kaminski MS, Gregory SA, Fehrenbacher L, et al. Acute and delayed hematologic toxicities associated with BexxarTM therapy are modest:overall experience in patients with low-grade and transformed low-grade NHL[J]. Blood, 2001, 98(11):339a.
    [14] Gregory SA, Leonard J, Coleman M, et al. Relationship of degree of bone marrow involvement with hematologic toxicity in patients with non-Hodgkin's lymphoma treated with tositumomab and iodine- 131tositumomab therapy[C]. Chicago:the 39th American Society of Clinical Oncology Annual Meeting, 2003.
    [15] Kaminski MS, Bennett J, Tuck M,et al. Lack of treatment-related MDS/AML in patients with follicular lymphoma after frontline therapy with tositumomab and iodine-131 tositumomab[C]. Chicago:the 39th American Society of Clinical Oncology Annual Meeting, 2003.
    [16] Hohenstein MA, Augustine SC, Rutar F, et al. Establishing an institutional model for the administration of tositumomab and Ⅰ-131tositumomab[J]. Semin Oncol, 2003, 30(suppl 4):39-49.
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    [8] 杨连君司晓辉隋延仿陈志南管昌田90Y标记单克隆抗体导向治疗肿瘤. 国际放射医学核医学杂志, 1996, 20(5): 205-207.
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    [10] 魏莉罗荣城 . 放射性核素标记抗CD20单克隆抗体治疗B细胞淋巴瘤的研究进展. 国际放射医学核医学杂志, 2006, 30(3): 153-157.
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  • 收稿日期:  2005-01-31

Bexxar治疗非霍奇金淋巴瘤的研究现状

  • 200233 上海, 上海交通大学附属第六人民医院核医学科

摘要: B细胞靶向特异性单克隆抗体的出现为惰性淋巴瘤的治疗提供了新的策略。由于淋巴瘤对辐射较为敏感,在过去的10年中,应用131I标记抗-CD20单克隆抗体(商品名:Bexxar)对化疗无效的非霍奇金淋巴瘤(NHL)患者进行放射免疫治疗取得了长足的发展。

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