N-乙酰氨基葡萄糖转移酶及相关显像剂摄取研究

梁杰 陈跃 匡安仁

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N-乙酰氨基葡萄糖转移酶及相关显像剂摄取研究

  • 基金项目:

    四川省科技厅应用基础资助项目(2006J13-032)

  • 中图分类号: Q555+.3;R817.4

Study on N-acetylglucosaminyl transferase and the uptake of the correlated imaging agent

  • CLC number: Q555+.3;R817.4

  • 摘要: N-乙酰氨基葡萄糖转移酶(GnT)通过影响糖链的改变而间接关系到肿瘤的发展与癌症患者的预后.研究肿瘤组织的糖基转移酶变化,有助于了解肿瘤的生物学行为机制.随着新型肿瘤葡萄糖类似物显像剂的发展,显像机制的研究进一步明确,为肿瘤的无创伤性诊治提供新途径.
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    [8] 徐莺莺,陆祎,张毅,等.肝癌细胞N-乙酰氨基葡萄糖基转移酶V表达受阻与内质网应激之间的关系.中国癌症杂志,2005,15(2):130-134.
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    [17] Ekunl A, Miyoshi E, Ko JH, et al. A glycomic approach to hepatic tumors in N-acetyglucosaminyltransferase Ⅲ (GnT-Ⅲ) transgenie mice induced by diethylnitrosamine (DEN):identification of haptoglobin as a target molecule of GoT-Ⅲ. Free Radic Res, 2002, 36(8):827-833.
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出版历程
  • 收稿日期:  2007-02-08

N-乙酰氨基葡萄糖转移酶及相关显像剂摄取研究

  • 1. 646000 四川, 四川省泸州医学院附属医院核医学科;
  • 2. 610041 成都, 四川大学华西医院核医学科
基金项目:  四川省科技厅应用基础资助项目(2006J13-032)

摘要: N-乙酰氨基葡萄糖转移酶(GnT)通过影响糖链的改变而间接关系到肿瘤的发展与癌症患者的预后.研究肿瘤组织的糖基转移酶变化,有助于了解肿瘤的生物学行为机制.随着新型肿瘤葡萄糖类似物显像剂的发展,显像机制的研究进一步明确,为肿瘤的无创伤性诊治提供新途径.

English Abstract

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