18F-氟脱氧葡萄糖PET及PET-CT在食管癌中的

杨吉刚 ,  李春林

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18F-氟脱氧葡萄糖PET及PET-CT在食管癌中的

  • 100050 北京, 首都医科大学附属北京友谊医院核医学科

    • 通讯作者: 杨吉刚, nmyangjigang@yahoo.com.cn ; 
  • 基金项目:

    首都医科大学附属北京友谊医院科研启动基金资助项目(2005-15)

  • 中图分类号: R817.4

Application of 18F-fluorodeoxyglucose PET and PET-CT imaging in esophageal cancer

  • Department of Nuclear Medicine, Beijing Friendship Hospital Affiliated to Capital University of Medical Sciences, Beijing 100050, China

    • Corresponding author: YANG Ji-gang, nmyangjigang@yahoo.com.cn ;

  • CLC number: R817.4

  • 摘要: 食管癌的预后较差,切除术的致死率和致残率较高,术前正确分期对确定治疗方案尤为重要。PET是对CT、MRI、食管镜等常规检查的有益补充。受分辨率的影响,PET较难确定肿瘤的浸润程度,但对远处转移灶的诊断明显优于CT、MRI等常规检查,诊断复发性食管癌准确率较高,能有效鉴别手术瘢痕和复发,有效评价放疗、化疗的疗效。结合传统影像学检查,18F-氟脱氧葡萄糖PET及PET-CT能较为准确地进行术前分期,纠正不正确的治疗方案,改善食管癌患者的预后。
    Abstract: Because of the poor prognosis for patients with esophageal cancer and the risks associated with surgical intervention, accurate staging is essential for optimal treatment planning. Positron emission tomography (PET) with 18F-fluorodeoxyglucose (FDG) is a useful adjunct to more conventional imaging modalities in this setting. 18F-FDG PET is not an appropriate first-line diagnostic procedure in the detection of esophageal cancer and is not helpful in detecting local invasion by the primary tumor. However, 18F-FDG PET is superior to anatomic imaging modalities in the ability to detect distant metastases. Metastases to the liver, lungs, and skeleton can readily be identified at 18F-FDG PET. In addition, 18F-FDG PET has proved valuable in determining the respectability of disease and allows scanning of a larger volume, which is possible with computed tomography. Recurrent disease is readily diagnosed and differentiated from scar tissue with 18F-FDG PET. In addition, 18F-FDG PET may play a valuable role in the follow up of patients who undergo chemotherapy and radiation therapy, allowing early changes in treatment for unresponsive tumors. The management of most patients with esophageal cancer can be improved with the use of 18F-FDG PET.
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    [2] Kato H, Kuwano H, Nakajima M, et al. Comparison between positron assessment of esophageal carcinoma. Cancer, 2002, 94(4):921-928.
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    [9] Nakamoto Y, Osman M, Cohade C, et al. PET/CT:comparison of quatltative tracer uptake between germanium and CT transmission attenuation-corrected images. J Nucl Med, 2002, 43(9):1137-1143.
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  • 收稿日期:  2005-09-27

18F-氟脱氧葡萄糖PET及PET-CT在食管癌中的

    通讯作者: 杨吉刚, nmyangjigang@yahoo.com.cn; 
  • 100050 北京, 首都医科大学附属北京友谊医院核医学科
  • 收稿日期: 2005-09-27
基金项目:  首都医科大学附属北京友谊医院科研启动基金资助项目(2005-15)

摘要: 食管癌的预后较差,切除术的致死率和致残率较高,术前正确分期对确定治疗方案尤为重要。PET是对CT、MRI、食管镜等常规检查的有益补充。受分辨率的影响,PET较难确定肿瘤的浸润程度,但对远处转移灶的诊断明显优于CT、MRI等常规检查,诊断复发性食管癌准确率较高,能有效鉴别手术瘢痕和复发,有效评价放疗、化疗的疗效。结合传统影像学检查,18F-氟脱氧葡萄糖PET及PET-CT能较为准确地进行术前分期,纠正不正确的治疗方案,改善食管癌患者的预后。

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