血管内照射防治血管成形术后再狭窄

王卫东

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血管内照射防治血管成形术后再狭窄

    作者简介: 王卫东(1968-),男,上海崇明人,博士研究生,主要从事核素治疗学研究。;
  • 中图分类号: R817.5

Endovascular irradiation for the prevention of restenosis after angio plasty

  • CLC number: R817.5

  • 摘要: PTCA(经皮穿刺冠状动脉成形术)是治疗冠状动脉狭窄最常用的方法,但术后6个月内再狭窄的发生率达40%~60%,始终是困绕医学界的一个难题。核素内照射治疗是目前解决这一难题最有前景的方法,最近几年来在血管核素内照射的机制、剂量、动物和临床实验及安全性等方面取得了一些进展。
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    [2] Teristein PS. Gamma versus beta radiation for the treament of restenosis[J]. Herz, 1998, 23:335-336.
    [3] Amols HI, Trichter F, Weinberger J. Intracoronary radiation for prevention of restenosis:dose perturbation caused by stents[J].Circulation, 1998, 98:2024-2029.
    [4] Kotzerke J, Rentschler M, Glatting G, et al. Dosimetry fundamentals of endovsacular therapy using Re-188 for the prevention of restenosis after angioplasty[J]. Nuklerarmedizin, 1998, 37(2):68-72.
    [5] Nath RC. Intravascular brachytherapy physics:report of AAPM Radiation Therapy Committee Task Group No.60[J]. Med Phys, 1999, 26:119-152.
    [6] Cousey BM, Colle R, Zimmerman BE. National radioactivity standards for beta-emitting radionnuclides used in intravascular brachytherapy[J]. Int J Radiat Oncol Bid Phys, 1998, 41:207-216.
    [7] Wohlfrom M, Kotzerke J, Kamenz J, et al. Endovascular irradiation with the liquid beta-emitter Rhenium-188 to reduce restenosis after experimental wall injury[J].Cardivasc Res, 2001, 49(1):169-176.
    [8] Lee J, Lee DS, Kim KM, et al. Dosimetry of rheniun-188 diethylene triamine penta-acetic acid for endvascular intraballoon brachytherapy after coronary angioplasty[J]. Eur J Nucl Med, 2000, 27(1):76-82.
    [9] Janicki C, Duggan DM, Coffey CW. Radiation dose from a phosphorous-32 impregnated wire mesh vascular stent[J]. Med Phys, 1997, 24:437-445.
    [10] Hehrlein C, Gollan C, Donges K, et al. Low-dose radioactive endovascular stentts prevent smooth muscle cell proliferation and neointimal hyperplasia in rabbits[J]. Circulation, 1995, 92(6):1570-1575.
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    [12] Makkar R, Whiting J, Li A, et al. Abeta-emitting liquid isotope filled balloon markedly inhibits restenosis in stented porcine coronary arteries[J]. J Am Coll Cardiol, 1998, 31(Suppl A):350A.
    [13] Condado JA, Waksman R, Calderas C, et al. Two-year follow-up after intracoronary gamma radiation therapy[J]. Cardiovasc Radiat Med, 1999, 1(1):30-35.
    [14] Coen VL, Knook AH, Wardeh AJ, et al. Endovascular brachytherapy in coronary arteries:the rotterdam experience[J]. Cardiovasc Radiat Med, 2000, 2(1):42-50.
    [15] Fox RA, Barker P, Guy D, et al. The use of 188Re to treat instent re-stenosis of coronary arteries[J]. Australas Phys Eng Sci Med, 2001, 24(3):160-165.
    [16] Amols HI. Methods to improve dose uniformity for radioactive stents in endovascular brachytherapy[J]. Cardiovasc Radiat Med, 1999, 1(3):270-277.
    [17] Giap H, Massullo V, Teirstein P, et al. Theoretical assessment of late cardiac complication from endovascular brachytherapy for restenosis prevention[J]. Cardiovasc Radiat Med, 1999, 1(3):233-238.
    [18] Teirstein PS, Massullo V, Jani S, et al. Two-year follow-up after catheter-based radiotherapy to inhibit coronary restenosis[J]. Circulation, 1999, 99(2):243-247.
    [19] Xu Z, Yang G, Reinstein LE, et al. Caculation of dose distribution near an innovative concentric balloon catheter for endovascular brachytherapy[J]. Cardiovasc Radiat Med, 2000, 2(1):26-31.
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  • 收稿日期:  2002-04-12

血管内照射防治血管成形术后再狭窄

    作者简介:王卫东(1968-),男,上海崇明人,博士研究生,主要从事核素治疗学研究。
  • 200032 上海, 复旦大学附属中山医院核医学科

摘要: PTCA(经皮穿刺冠状动脉成形术)是治疗冠状动脉狭窄最常用的方法,但术后6个月内再狭窄的发生率达40%~60%,始终是困绕医学界的一个难题。核素内照射治疗是目前解决这一难题最有前景的方法,最近几年来在血管核素内照射的机制、剂量、动物和临床实验及安全性等方面取得了一些进展。

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