两种<sup>99</sup>Tc<sup>m</sup>标记双功能螯合剂:NHS-MAG3和HYNIC

兰晓莉

两种⁹⁹Tc^m标记双功能螯合剂:NHS-MAG3和HYNIC

兰晓莉

文章导航 > 国际放射医学核医学杂志 > 2005, 29 > 1: (15-18)

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两种⁹⁹Tc^m标记双功能螯合剂:NHS-MAG3和HYNIC

兰晓莉

430022 武汉, 华中科技大学同济医学院附属协和医院核医学科
基金项目:
高等学校博士点基金项目(20030487013)

国家自然科学基金项目(30271439)
中图分类号: R817.9

Two bifunctional chelating agents used in ⁹⁹Tc^m labeling: NHS-MAG3 and HYNIC

LAN Xiao-li

Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Hua Zhong University of Science and Technology, Wuhan 430022, China
CLC number: R817.9

摘要: ⁹⁹Tc^m在标记蛋白、核酸、多肽和抗体时,常采用双功能螯合剂作为偶联剂的间接标记法,以避免直接标记所带来的损伤。研究表明,近年来常用的两种螯合剂NHS-MAG3及HYNIC合成路线清晰,偶联及标记方法成熟,标记率、放化纯及比活度较高,为核素分子显像提供了必要的基础条件和广阔的临床应用前景。
- 双功能螯合剂 /
- 巯基乙酰三甘氨酰-N-羟基丁二酰亚胺酯 /
- 肼基尼古酰胺 /
- 锝 /
- 同位素标记
Abstract: When protein, nucleic acid, polypeptide and antibody labeled with ⁹⁹Tc^m, bifunctional chelating agents(BFCA)are commonly used in order to avoid damages by directly labeling. We choose two BFCA:NHS-MAG3 and HYNIC as representation. The synthesis of these two BFCA is clear and the meth-ods of conjugating and labeling are mature. Through BFCA we can gain high radiolabeling yield, radiochemi-cal purity and specific activity. The usage of BFCA can provide necessary condition for molecular imaging and extensively clinical foreground.
- bifunctional chelating agents /
- N-hydroxysuccinimidyl S-acetyl-mercaptoacetyltriglycline /
- hydrazino nictinamide /
- tehntium /
- isotope labeling
本作品遵循Signature-Non-Commercial Use 4.0 International (CC BY-NC 4.0)协议

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两种⁹⁹Tc^m标记双功能螯合剂:NHS-MAG3和HYNIC

兰晓莉

430022 武汉, 华中科技大学同济医学院附属协和医院核医学科

收稿日期: 2004-07-16

基金项目: 高等学校博士点基金项目(20030487013)国家自然科学基金项目(30271439)

关键词:

摘要: ⁹⁹Tc^m在标记蛋白、核酸、多肽和抗体时,常采用双功能螯合剂作为偶联剂的间接标记法,以避免直接标记所带来的损伤。研究表明,近年来常用的两种螯合剂NHS-MAG3及HYNIC合成路线清晰,偶联及标记方法成熟,标记率、放化纯及比活度较高,为核素分子显像提供了必要的基础条件和广阔的临床应用前景。