核素炎症定位显像在炎症性肠道疾病中的临床应用

何薇; 蒋茂松

何薇 , 蒋茂松

文章导航 > 国际放射医学核医学杂志 > 2001, 25 > 1: (3-7)

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核素炎症定位显像在炎症性肠道疾病中的临床应用

何薇,
蒋茂松

200040 上海, 上海华东医院核医学科

作者简介: 何薇(1967-),女,浙江慈溪人,上海华东医院核医学科主治医生,硕士研究生,主要从事临床核医学研究。;

中图分类号: R817.4

Clinical evaluation of radiopharmaceuticals for the inflammatory localization of Crohn's disease and ulcerative colitis

HE Wei,

Department of Nuclear Medicine, Shanghai Hua Dong Hospital, Shanghai 200040, China
CLC number: R817.4

摘要: 核素炎症定位显像有助于早期诊断溃疡性结肠炎与Crohn's病,特别是能够判断疾病的活动度,评价其对治疗的反应。本文简单介绍几种用于这二种疾病诊断的放射性药物及各自临床应用价值。
- 溃疡性结肠炎 /
- Crohn's病 /
- 核素显像
Abstract: Radionuclide imaging is helpfulin the early diagnosis of ulcerative colitis and Crohn's disease, especially it can provide us the disease activity and evaluate their responses to therapy. Several radiopharmaceuticals for the diagnosis of these two diseases have been reviewed. Meanwhile their advantages and disadvantages have been dis-cussed.
- ulcerative colitis /
- Crohn's disease /
- radionuclideimaging
本作品遵循Signature-Non-Commercial Use 4.0 International (CC BY-NC 4.0)协议

[1]	Almers,Smedh K. Leukocyte scintigraphy,en-doscopy,airway,X-ray new methods for the diagnosis of colitis and Crohn's disease[J]. Lakartidningen,1998,95(9):860-862.
[2]	El-Maghraoui A,Dougados M,Freneaux E,et al.Concordance between abdominal scintigraphy using technetium hexamethyloproopylene amine oxine-la-belled leucocytes and ileocolonoscopy in patients with spondyloarthropathies and without clinical evidence of inflammatory bowel disease[J]. Rheumatol Oxford,1999,38(6):543-546.
[3]	de-Lima-Ramos PA. Scintingraphic assessment of the severity of inflammatory bowel disease using ⁹⁹Tc^m ex-ametazine-labelled leukocytes[J]. Rev Esp Med Nucl,1998,17,351-357.
[4]	Saverymuthu SH,Peters AM. Quantitative fecal indi-um-111-labelled leukocyte excretion in the assessment of disease in Crohn's disease[J]. Gastroenterology,1983,85:1333-1339.
[5]	Papos M,Varkonyi A,Lang J,et al. HM PAO-la-belled leukocyte scintigraphy in pediatric patients with inflammation bowel disease[J]. J Pediatr Gastroen-terol Nutr,1996,23:547-552.
[6]	Becker W. Guildelines for ⁹⁹Tc^m-HM PAO leeukocyte scintigraphy in inflammatory or infectious disease[J].Nuklearmedizin,1999,38(6 A),240-242.
[7]	Alonso JC,Lopez-Lonngo FJ,Lampreave JL,et al.Abdominal scintigraphy using ⁹⁹Tc^m-HMPAO-labelled leucocytes in patients with seronegative spoondylart-thropathies without clinical evidence of inflammatory bowel disease[J]. Eur J Nucl Med,1996,23:243-246.
[8]	Charron M P,Rosario F,Kocoshis S. Assessment of terminal ileal and colonic inflammation in Crohn's dis-ease with ⁹⁹Tc^m-WBC[J].Acta Paediatr,1999,88:193-195.
[9]	Arndt JW,Crootssholten M I,Van Hoge,et al. In-flammatory bowel disease activity assessment using ⁹⁹Tc^m-HM PAO-WBC[J]. Dig Dis Sci,1997,42:387-393.
[10]	Miyazaki C. Leukocyte scintigraphy:clinical applica-tion to inflammatory disease and marrow disease[J].KaKu Igaka,1995,32:703-707.
[11]	Charron M,Del-Rosario FJ,Kocoshis SA. Pediatric inflammatory:assessment with scintigraphy with scintigraphy with ⁹⁹Tc^m white blood cells[J]. Radiolo-gy,1999,212(2):507-513.
[12]	Fishman A,Rubin R,White J,et al. Localization of Fc and Fab fragments of nonspecific polyclonal IgG at fo-cal sites of inflammation[J]. J Nucl Med,1990,31:1199-1203.
[13]	Buijs WC,Oyen WJ,Dams ET,et al. Dynamic distri-bution and dosimetric evaluation of human nonspecific immunoglobulin Glabelled with ¹¹¹In or ⁹⁹Tc^m[J]. Nu-cl Med Commun,1998,19:743-751.
[14]	Kubo A,Tobo K. Evaluation of clinical utility of¹¹¹In-DTPA-IgG scintigraphy in the detection of inflamma-tion/infection-a report of multicenter phase Ⅲ clinical trials[J]. KaKu Igaka,997,399-412.
[15]	Sarikaya I,Bektas A,Ibis E,et al. Tc-99m detran and Tc-99m HIG findings in patients with ulcerative colitis[J]. Clin Nucl Med,1999,24(4):243-247.
[16]	Singh AK,Mishra P,Kashyap R,et al. A simplified kit for instant preparation of technetium-99m human immunoglobulin-G for imaging foci[J]. Nucl Med Bi-ol,1994,21:277-287.
[17]	Dams ET,Oyen WJ,Boerman OC,et al. Tech-netium-99m labeled to human immunoglobulin G through the nicotinyl hydrazine derivative a clinical study[J]. J Nucl Med,1998,39:119-124.
[18]	Steinstrasser A,Oberhausen E. Granulocyte labelling kit BW 250/183 results of the European multicenter trial[J]. Nuklearmedizin,1996,35:1-11.
[19]	Bhatti M,Chapman P,Peters M,et al. Visulising E-Selectin in the detection and evaluation of inflammato-ry bowel disease[J]. Gut,1998,43:40-47.
[20]	Gobar LS,Robin,Graharn.¹¹¹In-leukocyte imaging:a case of peritonitis mimicking inflammatory boweldisease[J]. J Nucl Med,1997,38. 1138-1140.

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