辐射及细胞因子对p21基因表达的调控作用

闫风琴; 鞠桂芝

闫风琴 , 鞠桂芝

文章导航 > 国际放射医学核医学杂志 > 2004, 28 > 6: (278-280)

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辐射及细胞因子对p21基因表达的调控作用

130021 长春, 吉林大学公共卫生学院放射生物学教研室
中图分类号: Q345⁺.2

The regulation of radiation and cytokines to p21 gene expression

Department of Radiation Biology, Pubilc Health School, Jilin University, Changchun 130021, China
CLC number: Q345⁺.2

摘要: p21基因是细胞周期的负向调控因子,在一定的因素诱导下,p21基因可有效地引起细胞周期G₁期和G₂期阻滞,从而在维持基因组稳定性中起重要作用。辐射及TGFβ1、TNFα、PTEN、IGF等因子均可诱导p21基因表达增高,而E1A、c-jun、Tbx2、PLD1和PLD2等因子则抑制p21基因表达。
- 辐射 /
- 细胞因子 /
- p21基因 /
- 基因表达调控
Abstract: p21 gene is a negative regulator of cell cycle, which affect cell cycle progression arrest at G₁ and G₂ by some factors induced. p21 gene plays an important role to maintain genomic stability. Radiation and TGFβ1, TNFα, PTEN, IGF can increase p21 gene expression, however E1A, c-jun, Tbx2, PLD1 and PLD2 can inhibit p21 gene expression.
- radiation /
- cytokine /
- p21 gene /
- gene expression regulation
本作品遵循Signature-Non-Commercial Use 4.0 International (CC BY-NC 4.0)协议

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辐射及细胞因子对p21基因表达的调控作用

130021 长春, 吉林大学公共卫生学院放射生物学教研室

收稿日期: 2004-07-11

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摘要: p21基因是细胞周期的负向调控因子,在一定的因素诱导下,p21基因可有效地引起细胞周期G₁期和G₂期阻滞,从而在维持基因组稳定性中起重要作用。辐射及TGFβ1、TNFα、PTEN、IGF等因子均可诱导p21基因表达增高,而E1A、c-jun、Tbx2、PLD1和PLD2等因子则抑制p21基因表达。