摘要:
目的: 探讨肝硬化患者治疗前后血清可溶性细胞间黏附分子-1(sICAM-1)水平变化与肝细胞损伤的关系。方法: 用酶联免疫吸附试验检测50例肝硬化患者和20例正常对照者血清sICAM-1水平。结果: 肝硬化患者血清sICAM-1水平高于正常对照组(t=2.874,P<0.01);肝硬化患者血清sICAM-1水平与谷草转氨酶(GOT)水平呈正相关(r=0.275,P<0.05),与血清白蛋白(ALB)水平呈负相关(r=-0.4812,P<0.01);从ChildA级到ChildC级,血清sICAM-1水平逐步升高(r=0.3698,P<0.05);重组人生长激素(rhGH)治疗组和常规治疗组治疗后GOT、血尿素氮(BUN)、总胆红素(SB)、肌酐(Cr)、sICAM-1水平均低于治疗前;rhGH治疗组治疗后BUN、Cr、sICAM-1水平较常规治疗组下降明显。rhGH治疗组和常规治疗组显效率、有效率、无效率分别为45.45%、36.36%、18.18%和36.36%、45.45%、27.27%。结论: 肝硬化患者血清sICAM-1水平增高与肝细胞损伤、肝功能障碍有关,血清sICAM-1水平监测可作为临床观察肝硬化患者病变活动的重要免疫学指标。
Abstract:
Objective: To investigate the level of serum soluble intercellular adhesion molecule-l(sICAM-1) and assess its role in liver function injury of cirrhosis. Methods: The sICAM-1 was measured by enzyme linked immunosorbent assay in serum samples collected from 50 liver cirrhosis patients and 20 healthy controls. Liver function tests performed in all samples. Results: Serum levels of sICAM-1 were signifi-cantly increased in patients with liver cirrhosis compared with healthy controls(t=2.874, P<0.01). Serum levels of sICAM-1 correlated positively with glutamic oxaloacetic transaminase(GOT)(r=0.2754, P<0.05) and negative with albumin(ALB) (r=-0.4812, P<0.01). Serum levels of sICAM-1 were correlated positively(r=0.3698, P<0.05) with assessment score of disease severity(Child classification). The contents of GOT, blood urea nitrogen(BUN), superfamily bilirubin(SB), creatinine(Cr), sICAM-1 were obviously lower than that of pretreatment. The contents of BUN、Cr、sICAM-1 comparision between recombination human growth hormone(rhGH) group and routine group in the after treatment were front obviously lower than that latter. The apparent efficiency, efficiency and inefficiency were 45.45%, 36.36% and 18.18% in rhGH group. The apparent efficiency, efficiency and inefficiency were 36.36%, 45.45%, and 27.27% in routine group. Conclusion: sICAM-1 is markedly elevated in liver cirrhosis and correlated with parameters of liver func-tion. sICAM-l may be useful in assessing the immunopathology of the disease process in liver cirrhosis.
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