低剂量照射在肿瘤治疗中的应用研究进展

张海兵; 章龙珍

低剂量照射在肿瘤治疗中的应用研究进展

张海兵 , 章龙珍

文章导航 > 国际放射医学核医学杂志 > 2008, 32 > 4: (243-246)

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Citation:

低剂量照射在肿瘤治疗中的应用研究进展

张海兵¹,
章龙珍^2, ,

1. 313000 湖州, 浙江省湖州市中心医院放疗科;
2. 221002 徐州, 徐州医学院附属医院放疗科

通讯作者: 章龙珍, jsxzzlz@126.com

基金项目:
国家自然科学基金资助项目(30770916)

Advance of treatment in tumor by low-dose radiation

ZHANG Hai-bing¹,
ZHANG Long-zhen^2, ,

1. Department of Radiation Oncology, Centrol Hospital of Huzhou, Zhejang Huzhou 313000, China;
2. Department of Radiation Oneology, Affiliated Hospital of Xuzhou Medical Colkge, Xuzhou 221002, China

Corresponding author: ZHANG Long-zhen, jsxzzlz@126.com

摘要: 电离辐射生物效应与辐射剂量和剂量率有关,大、中剂量照射以损伤效应为主,低剂量照射可诱导机体的兴奋效应、适应性反应、超敏感性、旁效应等。低剂量全身照射通过诱导免疫增强效应、超敏感性、激活抗氧化酶系统及肿瘤细胞凋亡等机制具有抗肿瘤作用,降低随后较大剂量辐射诱发的肿瘤发生率。目前。低剂量照射在肿瘤防治中的应用正成为研究的热点。
- 辐射剂量 /
- 全身照射 /
- 辐射耐受性 /
- 细胞凋亡 /
- 肿瘤治疗方案
Abstract: The biological effects of ionizing irradiation is related with dose and dose-rate.Medium to large dose irradiation can induce damaging effect to biosystem.but low dose radiation may induce adaptive response,hormesis,hyper.sensitiVeness and bystander effeeL Especially experimental data suggest that the antitumor effects of immune enhancement,intrinsic hypersensitivity,activation antioxidase enzymatic system and induction of apoptosis is produced by low-dose total body irradiation.Furthermore it call decrease relative cancer risk in exposed populations.Therefore.the antitumor effect by low-dose irradiation is being widely investigated and intensively researched.
- Radiation dosage /
- Whole.body irradiation /
- Radiation tolerance /
- Apoptosis /
- Antineoplatie protocols
本作品遵循Signature-Non-Commercial Use 4.0 International (CC BY-NC 4.0)协议

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低剂量照射在肿瘤治疗中的应用研究进展

张海兵¹
章龙珍^2, ,

通讯作者: 章龙珍, jsxzzlz@126.com

1. 313000 湖州, 浙江省湖州市中心医院放疗科;
2. 221002 徐州, 徐州医学院附属医院放疗科

收稿日期: 2008-03-02

基金项目: 国家自然科学基金资助项目(30770916)

关键词:

摘要: 电离辐射生物效应与辐射剂量和剂量率有关,大、中剂量照射以损伤效应为主,低剂量照射可诱导机体的兴奋效应、适应性反应、超敏感性、旁效应等。低剂量全身照射通过诱导免疫增强效应、超敏感性、激活抗氧化酶系统及肿瘤细胞凋亡等机制具有抗肿瘤作用,降低随后较大剂量辐射诱发的肿瘤发生率。目前。低剂量照射在肿瘤防治中的应用正成为研究的热点。