质子生物效应
Proton biological effectiveness
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摘要: 质子治疗已在发达国家中临床应用并取得重大进展。关于质子的生物效应,特别是低能质子的生物效应的研究对进一步提高临床治疗的疗效和精确度具有重要的指导作用。Abstract: Proton therapy technique is an advanced radiotherapy method for treating cancers.Much progresses have been gained in the study of the biological effectiveness of therapeutic protons, especially the low-energy protons, the potential instructive meaning in clinical therapy of this effect is discussed.
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Key words:
- proton therapy /
- relative biological effectiveness /
- Biological Bragg-peak
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[1] Belli M, Cera F, Cherubini R, et al.RBE-LET relationships for cell inactivation and mutation induced by low-energy protons in V79 cells further results at the LNL facility[J].Int J Radiat Biol, 1998, 74(4):501-509. [2] Deasy JO.A proton dose calculation algorithm for conformal therapy simulations based on Moliere's theorv of lateral deflections[J].Med Phys, 1998, 25(4):476-483. [3] Lomax AJ, Bortfeld T, Goitein G, et al.A treatment planning inter-comparison of proton and intensity modulated photon radiotherapy[J].Radiother Oncol, 1999, 51(3):257-271. [4] Paganetti H.Calculation of the spatial variation of relative biological effectiveness in a therapeutic proton field eye treatment[J].Phys Med Biol, 1998, 43(8):2147-2157. [5] Steel GG.From target to genes:a brief history of radio-sensitivity[J].Phys Med Biol, 1996, 41(2):205-222.
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